Response of metal-coordination-based polyelectrolyte complex micelles to added ligands and metals

Wang, Junyou; Guan, Wenjun; Tan, Tianhong; Saggiomo, Vittorio; Stuart, Martien A. Cohen; Velders, Aldrik H.

doi:10.1039/c9sm02386k

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…Since ionic-neutral copolymers co-assemble with a broad range of oppositely charged compounds, these have been exploited to encapsulate many different types of chemical species, including linear block (co)polymers, biopolymers, such as DNA [ 13 , 14 ], proteins [ 15 ], surfactants [ 16 ], metallic complexes [ 17 , 18 ], nanoparticles, and dendrimers [ 19 ]. The resultant core/shell hydrocolloids are referred to in the literature as complex coacervate core micelles (C3Ms), polyion complex (PIC) micelles, block ionomer complexes (BIC) and (micellar) interpolyelectrolyte complexes (IPEC), among others.…”

Section: Fundamentalsmentioning

confidence: 99%

On Complex Coacervate Core Micelles: Structure-Function Perspectives

2020

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The co-assembly of ionic-neutral block copolymers with oppositely charged species produces nanometric colloidal complexes, known, among other names, as complex coacervates core micelles (C3Ms). C3Ms are of widespread interest in nanomedicine for controlled delivery and release, whilst research activity into other application areas, such as gelation, catalysis, nanoparticle synthesis, and sensing, is increasing. In this review, we discuss recent studies on the functional roles that C3Ms can fulfil in these and other fields, focusing on emerging structure–function relations and remaining knowledge gaps.

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Section: Fundamentalsmentioning

confidence: 99%

On Complex Coacervate Core Micelles: Structure-Function Perspectives

2020

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“…The polymerization and co-assembly are further characterized with 1 H NMR with TSP as an internal standard (Figure S1). 41,42 The quantitative analysis indicates that more than 93% of the AA monomers is converted into PAA polymers (Table S1), about 76% of AA (defined as nanogel yield) are cross-linked in the PAA nanogels and more than 95% of the template polymers are released after the purification (Table S2).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Synthesis of Anionic Nanogels for Selective and Efficient Enzyme Encapsulation

Wan

Cai

et al. 2022

Langmuir

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Polyelectrolyte nanogels containing cross-linked ionic polymer networks feature both soft environment and intrinsic charges which are of great potential for enzyme encapsulation. In this work, well-defined poly(acrylic acid) (PAA) nanogels have been synthesized based on a facile strategy, namely, electrostatic assembly directed polymerization (EADP). Specifically, AA monomers are polymerized together with a crosslinker in the presence of a cationic-neutral diblock copolymer as the template. Effects of control factors including pH, salt concentration, and cross-linking degree have been investigated systematically, based on which the optimal preparation of PAA nanogels has been established. The obtained nanogel features not only compatible pocket for safely loading enzymes without disturbing their structures, but also abundant negative charges which enable selective and efficient encapsulation of cationic enzymes. The loading capacities of PAA nanogels for cytochrome (cyt c) and lysozyme are 100 and 125 μg/mg (enzyme/nanogel), respectively. More notably, the PAA network seems to modulate a favorable microenvironment for cyt c and induces 2-fold enhanced activity for the encapsulated enzymes, as indicated by the steady-state kinetic assay. Our study reveals the control factors of EADP for optimal synthesis of anionic nanogels and validates their distinctive advances with respect to efficient loading and activation of cationic enzymes.

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“…Oligomers dominate at low M-L 2 EO 4 concentration (<50 mM), while coordination polymers form mainly at high concentration . Upon combining with positive segments, the increased local concentration of M-L 2 EO 4 triggers an equilibrium shift to form coordination polymers under the designed M/DPA ratio. , Mixing transition metal ions, e.g., Zn/Mn, or lanthanide metal ions (Eu/Tb) does not disturb the linear and branched structure of coordination polymers, while it allows to incorporate different metals and consequently different functionalities in the structure. − The mixture with both transition and lanthanide metal ions, however, leads to structure conversion from linear chains to branched polymers with a controlled branch density depending on the Ln fraction . These designed coordination polymers with regulated structures and functions co-assemble with the PMPTC n –PEO 227 –PMPTC n triblock copolymer, which enables construction of well-defined PIC vesicles.…”

Section: Resultsmentioning

confidence: 99%

“…34 Upon combining with positive segments, the increased local concentration of M-L 2 EO 4 triggers an equilibrium shift to form coordination polymers under the designed M/DPA ratio. 37,38 Mixing transition metal ions, e.g., Zn/Mn, or lanthanide metal ions (Eu/Tb) does not disturb the linear and branched structure of coordination polymers, while it allows to incorporate different metals and consequently different functionalities in the structure. 39−41 The mixture with both transition and lanthanide metal ions, however, leads to structure conversion from linear chains to branched polymers with a controlled branch density depending on the Ln fraction.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Rational Polyelectrolyte Design Enables Multifunctional Polyion Complex Vesicles

Huang

Gao

Ding

et al. 2022

ACS Appl. Mater. Interfaces

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Polyion complex (PIC) vesicles prepared by polyelectrolyte assembly have attracted extensive attention as distinctive carriers and nanoreactors, particularly for biological cargoes. However, the constrained regulation of their structure and functionality at this stage hinder the application of PIC vesicles. Herein, we design a new asymmetric assembly system, namely cationic−neutral− cationic triblock copolymer co-assembly with a supramolecular ionic coordination polymer. The former creates poly(ethylene oxide) (PEO) loops upon complexation, which are favorable for vesicle fabrication, while the coordination polyelectrolyte composed of metal ions and a dipicolinic acid (DPA)-based bis-ligand features well-defined functionalities depending on the incorporated metal ions. Thus, the rational combination allows controlled fabrication of PIC vesicles with a modulated structure and functionalities. Moreover, the encapsulation and release of hydrophilic dextran based on different PIC vesicles has been realized. Our design integrates the advantages of both triblock and coordination polymers, and therefore demonstrates a novel strategy for harmonious regulation of the structure and functionality of PIC vesicles. The revealed findings and achieved properties shall be inspirational for developing functional PIC vesicles and boosting their applications towards demand encapsulation and delivery.

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Response of metal-coordination-based polyelectrolyte complex micelles to added ligands and metals

Abstract: Designed scenarios for investigating the dynamic properties of metal-coordination-based polyelectrolyte micelles by recording their response to added extra components including both ligands and metal ions.

Cited by 7 publications

References 35 publications

On Complex Coacervate Core Micelles: Structure-Function Perspectives

On Complex Coacervate Core Micelles: Structure-Function Perspectives

Synthesis of Anionic Nanogels for Selective and Efficient Enzyme Encapsulation

Rational Polyelectrolyte Design Enables Multifunctional Polyion Complex Vesicles

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