Response of lymphocytes of patients with schizophrenia to phytomitogens concanavalin A and phytohemagglutinin

Kovaleva, E. S.; Bonartsev, P D; Prilipko, L. L.

doi:10.1007/bf00799200

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Phenothiazines may also be responsible for some of the reported changes in cellular responses to mitogens. Inhibition of the responses of lymphocytes to PHA does occur with neuroleptics (Baker et al 1977) and has been reported in schizophrenia (Vartanian et al 1978;Kovaleva et al 1978).…”

Section: Schizophreniamentioning

confidence: 91%

Stress, immunity and illness — a review

1987

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SynopsisPsychological factors have long been thought to play a contributing role in either the predisposition, onset or course of various physical illnesses. Recently, rapid advances in immunology have created interest in the interaction between psychosocial factors, behaviour and the immune system. This paper reviews some of the models proposed to explain the relationship between psychological variables and physical illness and presents evidence for a contribution of psychological factors to certain illnesses in which abnormalities in immunologic state are thought to be important. From a somewhat different perspective, animal studies have demonstrated complex effects of stress, on disease susceptibility. Recent human studies have demonstrated consistent immunologic changes in people undergoing acute naturally occurring psychological stress such as bereavement or an important examination. In humans, the effects of chronic stress may be different from acute stress, corresponding to the findings in animals. Abnormalities in immunologic functioning and physical illness are reviewed for different psychiatric disorders — depression, anorexia nervosa and schizophrenia; depression is the only disorder which consistently demonstrated immunologic changes. Possible mechanisms for the stress/immune-change relationship are suggested.

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Section: Schizophreniamentioning

confidence: 91%

Stress, immunity and illness — a review

1987

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“…Blood leucocytes have been extensively studied (for review see Rud (1947)), and morphological abnormal lymphocytes have been described (Fieve et al (1966)). Changes have been described in the functional status of the lymphocytes as examined by stimulation with mitogens ( Kovaleva et al (1978)) and nerve antigens (Kuritzky et al (1976)).…”

Section: Lymphocytesmentioning

confidence: 99%

Lymphocyte subpopulations in peripheral blood from schizophrenic patients

Yyland

Ness

Lunde

1980

Acta Psychiatr Scand

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Patients with acute and chronic schizophrenia were examined for T and Fc receptor-bearing lymphocytes in blood by means of rosette techniques. The patients had normal numbers of peripheral blood lymphocytes. The percentage of T lymphocytes in patients with acute schizophrenia was reduced (60 +/-2%) compared with controls (66 +/- 1%) and patients with chronic schizophrenia (67 +/- 3%). The total number of T lymphocytes was significantly decreased in patients with acute schizophrenia had slightly elevated numbers (1,778 +/- 200 cells/mm3, P less than 0.002). The percentage and total numbers of Fc receptor-bearing lymphocytes were normal in both patient groups. Both immune mechanisms and the neuroleptic drug treatment may be of importance for the observed decrease in T lymphocyte numbers in blood from patients with acute schizophrenia.

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“…1977) . γ. τα άτυπα λεμφοκύτταρα παρουσιάζουν έντονη μεταβολική δραστη ριότητα (Bonartzev 1976, Kovalena 1977. δ. η απομάκρυνση ενός υποπληθυσμού λεμφοκυττάρων με αυξημένη προσκολλητικότητα σε γυάλινα σφαιρίδια από τις καλλιέργειες απο καθιστά επίσης την απαντηχικότητα των υπόλοιπων λεμφοκυττάρων στην ΡΗΑ και Con A (Liedeman και Prilipko 1978).…”

Section: αριθμόςunclassified

Μελέτη Της Ανοσολογικής Κατάστασης Των Σχιζοφρενών Αρρώστων

Βαϊδάκη¹

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Response of lymphocytes of patients with schizophrenia to phytomitogens concanavalin A and phytohemagglutinin

Cited by 7 publications

References 7 publications

Stress, immunity and illness — a review

Stress, immunity and illness — a review

Lymphocyte subpopulations in peripheral blood from schizophrenic patients

Μελέτη Της Ανοσολογικής Κατάστασης Των Σχιζοφρενών Αρρώστων

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