Response of generalized granuloma annulare to high-dose niacinamide

Abstract

A patient with generalized granuloma annulare experienced resolution of her lesions after six months of treatment with 1,500 mg/day of niacinamide. Niacinamide seems to be a reasonably safe drug that, even at relatively high doses, is associated with a low incidence of side effects. The participation of a delayed hypersensitivity reaction in the pathogenesis of granuloma annulare and possible mechanisms involving niacinamide in this type of reaction are discussed.

Granuloma annulare following waxing induced pseudofolliculitis-resolution with isotretinoin

“…Disseminated forms of granuloma annulare have been reported to respond to a varying degree to a variety of systemic therapies including dapsone, chlorambucil, potassium iodide, nicotinamide and phototherapy 9–10 . Treatment with retinoids has, as in our patient, resulted in resolution of some cases.…”

Treatment of generalized granuloma annulare – a systematic review

“…Niacinamide was reported to be an effective drug in the treatment of GGA as well . However, liver toxicity is an important adverse effect, and hepatic transaminase levels should be monitored during treatment …”

Exploring Clinical Associations Using ‘-Omics’ Based Enrichment Analyses

“…The association between “granuloma annulare” and “osteoarthritis” (OR 4.3, p = 1.1×10 −4 ) is interesting since both can be treated with niacin,[17], [18] suggesting that a common underlying pathway might exist. Likewise, the association between “pyloric stenosis” and “ventricular septal defect” (OR 12.1, p = 2.0×10 −3 ) is unknown although both are disorders of muscle tissue.…”