Response: Impact and outcomes of postoperative anaemia in colorectal cancer patients: a systematic review

Froud, J.; Poacher, A; Whittaker, Thomas; Williamson, John S.; Williams, G. L.

doi:10.1111/codi.15752

Colorectal Disease

2021

DOI: 10.1111/codi.15752

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Response: Impact and outcomes of postoperative anaemia in colorectal cancer patients: a systematic review

J. Froud

A Poacher

Thomas Whittaker

et al.

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“…We appreciate that Froud et al agrees with the study conclusion that further research is needed to ascertain the true prevalence of postoperative anaemia in colorectal cancer patients, given its potential to have negative impact on clinical and long-term functional outcome [2].…”

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confidence: 58%

“…We welcome the interest in our recently published systematic review investigating the impact and outcomes of postoperative anaemia in colorectal cancer patients [1] from Froud et al We are pleased to further the discussion on the risk bias in the systematic review. We appreciate that Froud et al agrees with the study conclusion that further research is needed to ascertain the true prevalence of postoperative anaemia in colorectal cancer patients, given its potential to have negative impact on clinical and long‐term functional outcome [2].…”

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confidence: 81%

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Reply to: JLJ Froud, AT Poacher, TM Whittaker, JS Williamson, GL Williams Impact and outcomes of postoperative anaemia in colorectal cancer patients: A systematic review Aileen Moncur, Manish Chowdhary, Yajing Chu, Nader K Francis

Moncur

Chowdhary

Chu³

et al. 2021

Colorectal Disease

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confidence: 58%

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confidence: 81%

Reply to: JLJ Froud, AT Poacher, TM Whittaker, JS Williamson, GL Williams Impact and outcomes of postoperative anaemia in colorectal cancer patients: A systematic review Aileen Moncur, Manish Chowdhary, Yajing Chu, Nader K Francis

Moncur

Chowdhary

Chu³

et al. 2021

Colorectal Disease

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In-Hospital Mortality and Associated Factors among Colorectal Cancer Patients in Germany

Kostev,

Krieg,

Krieg

et al. 2024

Cancers

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Background: In the present study, we used the data from 14 hospitals to systematically evaluate the in-hospital mortality of patients with colorectal cancer as well as its influencing factors in Germany. Methods: This multicenter cross-sectional study included hospitalized patients with a main diagnosis of colorectal cancers in the period between January 2019 and July 2023. The outcome of the study was the prevalence of in-hospital mortality. To access the associations between demographic and clinical variables and in-hospital mortality, univariable and multivariable logistic regression analyses were conducted. Results: A total of 4146 colorectal cancer patients (mean age: 70.9 years; 45.3% female) were included. The in-hospital mortality rate was 8.7%. In a multivariable regression, seven variables were significantly associated with an increased in-hospital mortality, including ages of 71–80 years (OR: 2.08; 95% CI: 1.01–4.29), an age group >80 years (OR: 2.44; 95% CI: 1.18–5.05) as compared to an age group ≤ 50 years, patient clinical-complexity level (PCCL) 3 (OR: 3.01 95% CI: 1.81–4.99) and PCCL 4 (OR: 3.76; 95% CI: 2.22–6.38) as compared to PCCL 0, the presence of distant metastases (OR: 4.95; 95% CI: 3.79–6.48), renal failure (OR: 2.38; 95% CI: 1.80–3.14), peritonitis (OR: 1.87; 95% CI: 1.23–2.85), acute posthemorrhagic anemia (OR: 1.55; 95% CI: 1.11–2.15), and respiratory failure (OR: 3.28; 95% CI: 2.44–4.41). Conclusions: Our findings underscore the critical role of renal failure, peritonitis, acute posthemorrhagic anemia, and respiratory failure in influencing the mortality outcomes of colorectal cancer patients during hospitalization. The awareness and management of these risk factors may guide clinicians in formulating targeted interventions to improve patient outcomes and enhance the quality of care for individuals with colorectal cancer.

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Response: Impact and outcomes of postoperative anaemia in colorectal cancer patients: a systematic review

Cited by 2 publications

References 3 publications

Reply to: JLJ Froud, AT Poacher, TM Whittaker, JS Williamson, GL Williams Impact and outcomes of postoperative anaemia in colorectal cancer patients: A systematic review Aileen Moncur, Manish Chowdhary, Yajing Chu, Nader K Francis

Reply to: JLJ Froud, AT Poacher, TM Whittaker, JS Williamson, GL Williams Impact and outcomes of postoperative anaemia in colorectal cancer patients: A systematic review Aileen Moncur, Manish Chowdhary, Yajing Chu, Nader K Francis

In-Hospital Mortality and Associated Factors among Colorectal Cancer Patients in Germany

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