Response by Magnussen et al to Letter Regarding Article, “Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)”

Magnussen, Christina; Ojeda, Francisco; Schnabel, Renate B.

doi:10.1161/circulationaha.118.033968

Cited by 70 publications

(98 citation statements)

References 6 publications

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“…Although there is an abundance of literature to support the relationship between NT-pro-BNP and the risk of AF, sex-specific effects have only sparsely been reported 8 9 25. Recently, the BiomarCaRE consortium showed that increases in NT-pro-BNP conferred an 11% greater excess risk of AF in women than men 11. Although this sex difference was not statistically significant in BiomarCaRE, it is directionally consistent with the 22% greater excess risk of AF in women than men associated with NT-pro-BNP reported in this study.…”

Section: Discussionsupporting

confidence: 73%

“…More recently, several inflammatory, cardiac, and renal markers have also been associated with the risk of AF,8–10 although the evidence is inconsistent and often not provided separately for women and men. However, the BiomarCaRE consortium recently demonstrated that there are sex differences in the association between some, mostly classical, risk factors and the risk of AF 11. Robust evidence on the existence of sex differences in risk factors for AF would provide new insights in the sex-specific aetiology of AF and could provide an impetus to take such differences into account in clinical guidelines, clinical decision-making, and health promotion efforts 12…”

Section: Introductionmentioning

confidence: 99%

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Established and novel risk factors for atrial fibrillation in women compared with men

Peters

Woodward

2018

Heart

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Established and novel risk factors for atrial fibrillation in women compared with men

Peters

Woodward

2018

Heart

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“…36 Only 3 of the included studies, however, provided sex-specific estimates. 36 37 Therefore, the current study adds to the body of knowledge by comprehensively determining sex differences in the impact of BMI on future incident AF (including providing BMI-specific HRs) and confirms that associations between BMI and future development of AF are significant in both sexes but differ in size.…”

Section: Discussionsupporting

confidence: 66%

Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study

Ball

Løchen

Wilsgaard

et al. 2018

JAHA

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BackgroundAtrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated.Methods and ResultsData from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications.Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m2 compared with 23 kg/m2 were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk.ConclusionsWithin a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women.

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“…The MB-LATER score good predictive ability for VLRAF could be partly explained by higher AF prevalence in men. 40,41…”

Section: Mb-latermentioning

confidence: 99%

Clinical scores used for the prediction of negative events in patients undergoing catheter ablation for atrial fibrillation

Kosich

Schumacher

Potpara³

et al. 2019

Clinical Cardiology

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Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in adults. Catheter ablation (CA) is one of the most important management strategies to reduce AF burden and AF‐associated complications. In order to stratify the risk of adverse events and to predict treatment success in AF patients undergoing CA, several risk stratification scores had been developed during the last decade. The aim of this review is to provide an overview of the most important clinical risk scores predicting rhythm outcomes, electro‐anatomical substrate and mortality in AF.

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Response by Magnussen et al to Letter Regarding Article, “Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)”

Cited by 70 publications

References 6 publications

Established and novel risk factors for atrial fibrillation in women compared with men

Established and novel risk factors for atrial fibrillation in women compared with men

Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population‐Based Tromsø Study

Clinical scores used for the prediction of negative events in patients undergoing catheter ablation for atrial fibrillation

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