“…Infection frequently spreads to the paranasal sinuses, larynx and bronchi, and obstruction of the Eustachian tubes can lead to otitis media. Each of the HPIVs has been associated with a similar broad spectrum of respiratory tract disease including the common cold, croup, bronchitis, bronchiolitis, and pneumonia, but certain serotypes are more frequently associated with certain illnesses [3,4,10,11]. For example, HPIV1 and 2 are more frequently associated with laryngotracheobronchitis (croup), and HPIV3 is more likely than HPIV1 or 2 to spread to the smaller airways, causing bronchiolitis and pneumonia resembling that of RSV [2,15,16].…”