Respiratory toxicity of multi-wall carbon nanotubes

Muller, Julie; Huaux, François; Moreau, Nicolas; Misson, Pierre‐Damien; Heilier, Jean-François; Delos, Monique; Arras, Mohammed; Fonseca, A.; Nagy, J.B.; Lison, Dominique

doi:10.1016/j.taap.2005.01.008

Cited by 1,020 publications

(723 citation statements)

References 22 publications

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“…However, there are many reports of the toxicity caused by single-walled carbon nanotubes (SWCNT) and multiwall carbon nanotubes (MWCNT) such as oxidative stress of human keratinocyte cells [123,124], inflammatory and fibrotic reactions in rats' lungs [125] and inhibition of human HEK293 cells [126].…”

Section: Nanotubular Structuresmentioning

confidence: 99%

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

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Over the last 40 years, electrically conductive polymers have become well established as important electrode materials. Polyanilines, polythiophenes and polypyrroles have received particular attention due to their ease of synthesis, chemical stability, mechanical robustness and the ability to tailor their properties. Electrochemical synthesis of these materials as films have proved to be a robust and simple way to realise surface layers with controlled thickness, electrical conductivity and ion transport. In the last decade, the biomedical compatibility of electrodeposited polymers has become recognised; in particular, polypyrroles have been studied extensively and can provide an effective route to pharmaceutical drug release. The factors controlling the electrodeposition of this polymer from practical electrolytes are considered in this review including electrolyte composition and operating conditions such as the temperature and electrode potential. Voltammetry and current-time behaviour are seen to be effective techniques for film characterisation during and after their formation. The degree of take-up and the rate of drug release depend greatly on the structure, composition and oxidation state of the polymer film. Specialised aspects are considered, including galvanic cells with a Mg anode, use of catalytic nanomotors or implantable biofuel cells for a self-powered drug delivery system and nanoporous surfaces and nanostructures. Following a survey of polymer and drug types, progress in this field is summarised and aspects requiring further research are highlighted.

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Section: Nanotubular Structuresmentioning

confidence: 99%

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

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“…In in vivo experiments, the pulmonary toxicity of CNTs was evaluated by intratracheal instillation, and the carcinogenicity of CNTs such as asbestos was tested by intraperitoneal injection into rats or mice (Muller et al, 2005;Inoue et al, 2008;Poland et al, 2008;Takagi et al, 2008). These experiments found that CNTs can induce inflammation, fibrosis, and granulomas in the lungs and that CNTs have a carcinogenic effect in the abdominal cavity.…”

Section: Introductionmentioning

confidence: 99%

Proteomics-based safety evaluation of multi-walled carbon nanotubes

Haniu

Matsuda

Takeuchi

et al. 2010

Toxicology and Applied Pharmacology

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“…The research covering the new types of NPM is limited and the number of studies of the environmental impacts of NPM are few. Carbon nanotubes have been shown to cause granulomas in the lungs of animals, an immunological response to foreign objects (Lam et al, 2004;Warheit et al, 2004;Muller et al, 2005;Shvedova et al, 2005), and was found in one study to be more toxic than carbon black and quartz (Lam et al, 2004). Fullerenes have been shown in studies to be bioavailable when released in aqueous environments, cause lipid peroxidation in fishbrain (Oberdorster, 2004a) and inhibit bacterial growth (Fortner et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticulate materials and regulatory policy in Europe: An analysis of stakeholder perspectives

et al. 2006

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The novel properties of nanoparticulate materials (NPM) and the rapid development of NPM based products have raised many unanswered questions and concerns by different stakeholders over its consequences for the environment and human health. These concerns have led to an increasing discussion in both the US and Europe about possible regulatory policies for NPM. In this article a comparative study of stakeholdersÕ perceptions on regulatory policy issues with NPM in Europe is presented. It was found that industry wants to regulate this area if the scientific evidence demonstrates that NPM are harmful, but also that the regulatory bodies do not find it necessary at this point of time to regulate until scientific evidence demonstrates that NPM are harmful. This research therefore shows that there will most likely not be any regulatory interventions until there is an established and convincing scientific knowledge base demonstrating that NPM can be hazardous. It is furthermore discussed in this article the different roles and responsibilities of the stakeholders in financing the research required to establish the necessary level of fundamental scientific evidence. It was also found that the activity of the regulatory bodies on this issue differ between the European countries.

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Respiratory toxicity of multi-wall carbon nanotubes

Cited by 1,020 publications

References 22 publications

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Proteomics-based safety evaluation of multi-walled carbon nanotubes

Nanoparticulate materials and regulatory policy in Europe: An analysis of stakeholder perspectives

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