Respiratory syncytial and influenza viruses in children under 2 years old with severe acute respiratory infection (SARI) in Maputo, 2015

Pale, Mirela; Nacoto, Afonso; Tivane, Almiro; Nguenha, Neuza; Machalele, Loira; Gundane, Félix; Muteto, Délcio; Chilundo, Josina; Mavale, Sandra; Baltazar, Cynthia Semá; Pires, Germano; Augusto, Orvalho; Mussá, Tufária; Gudo, Eduardo Samo

doi:10.1371/journal.pone.0186735

Cited by 14 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrary to the high RSV rate in western settings [ 29 ] and a study from Ghana [ 18 ], we documented RSV infection in only a fifth of all infant ALRI and about a third of bronchiolitis cases.RSV prevalence in our study was similar to a study in Maputo [ 30 ], but higher than other studies documenting 9–15% prevalence [ 10 , 20 – 22 ]. While the strict exclusion of risk populations may affect our prevalence rate, the younger age of our patients (less than 6 months) may also be the reason for higher prevalence compared to the previous African studies [ 20 – 22 ].…”

Section: Discussionsupporting

confidence: 89%

Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants

Weldetsadik

Riedel

2021

BMC Pediatr

View full text Add to dashboard Cite

Background Respiratory Syncytial Virus (RSV) is the commonest cause of acute lower respiratory infections (ALRI) in infants. However, the burden of RSV is unknown in Ethiopia. We aimed to determine the prevalence, seasonality and predictors of RSV infection in young infants with ALRI for the first time in Ethiopia. Methods We performed RSV immuno-chromatographic assay from nasopharyngeal swabs of infants, 29 days to 6 months of age. We included the first 10 eligible infants in each month from June 2018 to May 2019 admitted in a tertiary pediatric center. Clinical, laboratory and imaging data were also collected, and chi-square test and regression were used to assess associated factors with RSV infection. Results Among a total of 117 study children, 65% were male and mean age was 3 months. Bronchiolitis was the commonest diagnosis (49%). RSV was isolated from 26 subjects (22.2%) of all ALRI, 37% of bronchiolitis and 11% of pneumonia patients. Although RSV infection occurred year round, highest rate extended from June to November. No clinical or laboratory parameter predicted RSV infection and only rainy season (Adjusted Odds Ratio (AOR) 10.46 [95%. C.I. 1.95, 56.18]) was independent predictor of RSV infection. Conclusions RSV was isolated in a fifth of young infants with severe ALRI, mostly in the rainy season. Diagnosis of RSV infection in our setting require specific tests as no clinical parameter predicted RSV infection. Since RSV caused less than a quarter of ALRI in our setting, the other causes should be looked for in future studies.

show abstract

Section: Discussionsupporting

confidence: 89%

Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants

Weldetsadik

Riedel

2021

BMC Pediatr

View full text Add to dashboard Cite

show abstract

“…Studies on S&S of RSV in the pediatric population (25 studies) took place in both community and clinical settings, and S&S were reported by both caregivers (six studies) 19 , 20 , 21 , 39 , 40 , 41 and clinicians (22 studies) 19 , 20 , 21 , 26 , 27 , 28 , 29 , 34 , 35 , 37 , 38 , 39 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ; we analyzed and present these two sets separately. In addition, two publications presented clinician‐reported S&S in the intensive care unit (ICU).…”

Section: Resultsmentioning

confidence: 99%

Systematic literature review of the signs and symptoms of respiratory syncytial virus

Colosia

Costello²,

McQuarrie

et al. 2023

Influenza Resp Viruses

View full text Add to dashboard Cite

Respiratory syncytial virus (RSV) is responsible for over 30 million lower respiratory tract infections (LRTIs) and 3 million hospitalizations worldwide each year. Despite the risk RSV poses to young children, older adults, and individuals with comorbidities or suppressed immunity, there is limited understanding of RSV symptom presentation across these at‐risk groups, and there is no vaccine for RSV. We conducted two systematic literature reviews (SLRs) of studies that document signs and symptoms (S&S) of RSV in (1) children aged ≤5 years and (2) immunocompromised adolescents and adults, and adults at high risk for severe RSV due to age or comorbidities. Symptom duration and hospital length of stay (LOS) were explored. Electronic database searches were performed following PRISMA guidelines. Studies captured RSV S&S across community and hospital settings. Clinicians and caregivers reported ( n = 25 studies) nasal discharge/congestion, cough, shortness of breath, feeding abnormalities, and fever in ≥40% of children across studies and settings. Median hospital stays for children ranged from 2 days in the United States to 7.5 days in China. High‐risk adults with RSV ( n = 6 studies) commonly (≥40% of adults) reported cough, sputum, dyspnea, and fever/feverishness. Median length of hospital stay in adults ranged from 6 to 15 days across studies. Caregivers and clinicians reported similar RSV S&S in young children, including upper and lower respiratory and systemic symptoms. In high‐risk and immunocompromised adults, the most frequent (in multiple publications) and commonly reported RSV S&S were primarily LRTI symptoms. RSV symptoms could last for weeks and are variable based on geography.

show abstract

“…The most common cause of SARI in children is viral infections [5][6][7][8][9][10], including influenza viruses A and B (Flu A/B); respiratory syncytial virus (RSV); adenovirus (ADV); parainfluenza virus (PIV) 1-3; picornavirus (PIC), which mainly includes human rhinovirus (RV) and human enterovirus (EV); human coronaviruses (HCoV), which includes OC43, 229E, NL63, and HKU; human bocavirus (HBoV); and human metapneumovirus (HMPV). Although the viral and epidemiological profiles of pediatric patients with SARI vary among countries [4,[7][8][9][10][11][12][13][14][15], few studies have comprehensively compared the viral and epidemiological profiles of pediatric patients with SARI in different geographic areas or climate zones within the same country, such as China.…”

Section: Introductionmentioning

confidence: 99%

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Zhao

Shen

et al. 2019

BMC Infect Dis

View full text Add to dashboard Cite

Background No comparison data have been reported on viral and epidemiological profiles of hospitalized children with severe acute respiratory infection (SARI) in Beijing or Shanghai, China. Methods We collected 700 nasopharyngeal aspirates (NPA) from hospitalized children with SARI in Beijing (northern China) and Shanghai (southern China). Multiple respiratory viruses (including 15 common viruses) were screened by validated polymerase chain reaction (PCR) or real-time reverse transcription-PCR assays and confirmed by sequencing. Demographic data and the distribution of viral infections were also examined. Results Of 700 samples, 547 (78.1%) tested positive for viral infections. The picornaviruses (PIC), which included rhinovirus (RV) and enterovirus (EV), were the most common (34.0%), followed by respiratory syncytial virus (RSV) (28.3%), human bocavirus (HBoV) (19.1%), adenovirus (ADV) (13.7%), human coronaviruses (HCoV) (10.7%), influenza A and B (8.9%), parainfluenza virus (PIV 1–3) (7.9%), and human metapneumovirus (HMPV) (5.0%). PIC (RV/EV) and RSV were the most prevalent etiological agents of SARI in both cities. The total and age-matched prevalence of RSV, HCoV, and hMPV among SARI children under 5 years old were significantly higher in Beijing than in Shanghai. Different age and seasonal distribution patterns of the viral infections were found between Beijing and Shanghai. Conclusions Viral infection was tested and shown to be the most prevalent etiological agent among children with SARI in either the Beijing or the Shanghai area, while showing different patterns of viral and epidemiological profiles. Our findings provide a better understanding of the roles of geographic location and climate in respiratory viral infections in hospitalized children with SARI.

show abstract

Respiratory syncytial and influenza viruses in children under 2 years old with severe acute respiratory infection (SARI) in Maputo, 2015

Cited by 14 publications

References 36 publications

Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants

Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants

Systematic literature review of the signs and symptoms of respiratory syncytial virus

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Contact Info

Product

Resources

About