Respiratory Pathogens in Children 1 Month to 5 Years of Age Presenting With Undifferentiated Acute Respiratory Distress in 2 District-Level Hospitals in Ghana

Wilson, Patrick T.; Baiden, Frank; Brooks, Joshua C; Giessler, Katie; Apio, Gavin; Punguyire, Damien; Moresky, Rachel T; Sylverken, Justice; Nyarko-Jectey, Kwadwo; Tagbor, Harry; LaRussa, Philip

doi:10.1093/jpids/piy090

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Following closely were rhinovirus at 32% and influenza A at 20%. While respiratory syncytial virus is globally recognized as a primary cause of hospitalization [24,25] and a significant contributor to child mortality [24,25], it does not always emerge as the most identified virus in respiratory infections among children [19,[26][27][28]. Indeed, various epidemiological studies on pediatric patients have indicated that other viruses, particularly human rhinovirus/enterovirus, may be more commonly associated with children's respiratory infections [19,26,27].…”

Section: Discussionmentioning

confidence: 99%

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Acute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy

Falsaperla,

Sortino,

La Cognata

et al. 2024

Diagnostics

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In Sicily (Italy), respiratory syncytial virus (RSV), rhinovirus (HRV), and influenza virus triggered epidemics among children, resulting in an increase in acute respiratory tract infections (ARTIs). Our objective was to capture the epidemiology of respiratory infections in children, determining which pathogens were associated with respiratory infections following the lockdown and whether there were changes in the epidemiological landscape during the post-SARS-CoV-2 pandemic era. Materials and Methods: We analyzed multiplex respiratory viral PCR data (BioFire® FilmArray® Respiratory Panel 2.1 Plus) from 204 children presenting with respiratory symptoms and/or fever to our Unit of Pediatrics and Pediatric Emergency. Results: Viruses were predominantly responsible for ARTIs (99%), with RSV emerging as the most common agent involved in respiratory infections, followed by human rhinovirus/enterovirus and influenza A. RSV and rhinovirus were also the primary agents in coinfections. RSV predominated during winter months, while HRV/EV exhibited greater prevalence than RSV during the fall. Some viruses spread exclusively in coinfections (human coronavirus NL63, adenovirus, metapneumovirus, and parainfluenza viruses 1–3), while others primarily caused mono-infections (influenza A and B). SARS-CoV-2 was detected equally in both mono-infections (41%) and coinfections (59%). Conclusions: Our analysis underlines the predominance of RSV and the importance of implementing preventive strategies for RSV.

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