2008
DOI: 10.1136/thx.2007.090167
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Abstract: Background: Respiratory muscle unloading during exercise could improve locomotor muscle oxygenation by increasing oxygen delivery (higher cardiac output and/or arterial oxygen content) in patients with chronic obstructive pulmonary disease (COPD). Methods: Sixteen non-hypoxaemic men (forced expiratory volume in 1 s 42.2 (13.9)% predicted) undertook, on different days, two constant work rate (70-80% peak) exercise tests receiving proportional assisted ventilation (PAV) or sham ventilation. Relative changes (D%)… Show more

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Cited by 137 publications
(124 citation statements)
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“…Isotime responses other than inspiratory capacity and dyspnoea Validity The physiological meaning of isotime measurements depends on the variable and intervention, but in general terms, isotime reduction in V′O 2 , V′CO 2 , V′E , leg effort, muscle fatigue and [La − ] a are considered markers of increased aerobic and decreased anaerobic energy transfer in the working muscles [98,111,113,126]. A decrease in isotime V′E may also be the consequence of reduced dead space volume to tidal volume ratio, because the metabolic and acid-base ventilatory demands of the task have been reduced or because the patient adopts a more efficient breathing pattern [45,101,114,115,118,127].…”
Section: Discussionmentioning
confidence: 99%
“…Isotime responses other than inspiratory capacity and dyspnoea Validity The physiological meaning of isotime measurements depends on the variable and intervention, but in general terms, isotime reduction in V′O 2 , V′CO 2 , V′E , leg effort, muscle fatigue and [La − ] a are considered markers of increased aerobic and decreased anaerobic energy transfer in the working muscles [98,111,113,126]. A decrease in isotime V′E may also be the consequence of reduced dead space volume to tidal volume ratio, because the metabolic and acid-base ventilatory demands of the task have been reduced or because the patient adopts a more efficient breathing pattern [45,101,114,115,118,127].…”
Section: Discussionmentioning
confidence: 99%
“…(6,7) Nutritional changes, weight loss, and skeletal muscle dysfunction can also occur, especially in the later stages of the disease. (8) However, in the study in question, the authors found that the OUES was within the predicted range for normal individuals. This finding suggests that cardiopulmonary reserve was adequate in the study population.…”
mentioning
confidence: 79%
“…In the present study, we found that the perception of leg fatigue was greater among the patients with a progressive pattern of DH than among those with a stable pattern of DH, although the difference was not statistically significant (Table 3). There is evidence suggesting that oxygen delivery to the appendicular muscles during exercise is reduced in patients with COPD, (34) and some of the interventions that reduce respiratory muscle overload, such as the use of bronchodilators (35) and noninvasive positive pressure ventilation, (36) are associated with a reduced sensation of leg discomfort. Therefore, we speculate that because of greater respiratory muscle overload, oxygen delivery to the legs of patients with progressive DH is impaired, which causes greater sensation of discomfort.…”
Section: Discussionmentioning
confidence: 99%