Respiratory infections and their influence on lung function in children: a multiple regression analysis.

Yarnell, J.W.G.; Leger, A. S. St

doi:10.1136/thx.36.11.847

Cited by 14 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The causative organism was not isolated in the majority of cases. Abnormalities of lung function are known to occur in the long term in children who have not received immunosuppressive therapy [8,37,38] and such sequelae may also occur in those children who have had significant lower respiratory tract infection during treatment for cancer. It may be unclear, however, whether it is the underlying infection or the cytotoxic chemotherapy that has resulted in lung toxicity in these patients.…”

Section: Discussionmentioning

confidence: 99%

Lung function and exercise capacity in survivors of childhood leukaemia

Jenney

Faragher

Jones

et al. 1995

Med. Pediatr. Oncol.

106

View full text Add to dashboard Cite

The survival from acute lymphoblastic leukaemia in childhood is now approximately 60-70%, and from acute myeloid leukaemia, up to 50%. However, there is little information on the effects of intensive chemotherapy and radiotherapy used in the treatment of these conditions on lung function and exercise capacity in the long term. Severity survivors of acute leukaemia from one centre in the UK were studied. Measurements of lung volumes, spirometry and transfer factor were made. Each child also performed a standard, symptom-limited maximal exercise test on a cycle ergometer. Predictive equations for indices of lung function and exercise tolerance were calculated from 146 age- and sex-matched control subjects. The results of the survivors of leukaemia were compared to these. There was a significant reduction of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), total lung capacity (TLC), and transfer for carbon monoxide (DLCO; P < 0.05 for each measurement), in the survivors of leukemia when compared to the control subjects. In addition, there was a mild but significant reduction of both maximal and submaximal indices of exercise capacity in the leukaemic group. A multivariate analysis was carried out to identify those variables acting independently to reduce lung volumes. For FEV1, FVC and TLC, these were craniospinal irradiation, cyclophosphamide and chest complications during treatment. For a reduction in DLCO, the significant factors were administration of anthracyclines, craniospinal irradiation and bone marrow transplantation. Survivors of acute leukemia have impaired pulmonary function and exercise capacity. Long-term cardiopulmonary follow-up may be necessary and new regimens devised which reduce long-term toxicity without compromising survival rates.

show abstract

Section: Discussionmentioning

confidence: 99%

Lung function and exercise capacity in survivors of childhood leukaemia

Jenney

Faragher

Jones

et al. 1995

Med. Pediatr. Oncol.

106

View full text Add to dashboard Cite

show abstract

“…There have been a number of reports of an association of respiratory morbidity with tobacco smoking in the home, 16>17>18 and with the use of gas for cooking. 13 -19 ' 20 There has been described an association between respiratory morbidity and respiratory symptoms in other family members, particularly parents 8 -21 - 22 and siblings. 21 ' 22 Association between current respiratory morbidity and respiratory disease in infancy has also been described.…”

Section: Confounding Factorsmentioning

confidence: 99%

The Hamilton Study: Distribution of Factors Confounding the Relationship between Air Quality and Respiratory Health

Pengelly

Kerigan

Goldsmith

et al. 1984

Journal of the Air Pollution Control Association

View full text Add to dashboard Cite

Hamilton, Ontario is an industrial city with a population of 300,000 which is situated at the western end of Lake Ontario. Canada's two largest iron and steel mills are located here; the city historically has had relatively poor air quality, which has improved markedly in the last 25 years. Concern about the health effects of current air quality recently led us to carry out an epidemiological study of the effects of air pollution on the respiratory health of over 3500 school children. Respiratory health was measured by pulmonary function testing of each child, and by an assessment of each child's respiratory symptoms via a questionnaire administered to the parents. Previous studies had shown that other environmental factors (e.g. parental smoking, parental cough, socioeconomic level, housing, and gas cooking) might also affect respiratory health, and thus "confound" any potential relationships between health and air pollution. The questionnaire also collected information on many of these confounding factors. For the purposes of initial analysis, the city was divided Into five areas in which differences In air quality were expected. In general, factors which have been associated with poor respiratory health were observed to be more prevalent in areas of poorer air quality.

show abstract

“…Several retrospective and prospective studies have investigated the role of viral infections (72,73). Mild wheezing in association with viral respiratory tract infections occurs in 10-20% of all infants and children and has an excellent prognosis (29.38,62).…”

Section: Viral Infectionmentioning

confidence: 99%