Respiratory Disorders Resulting From Exposure to Low Concentrations of Ammonia

Mahdinia, Mohsen; Adeli, Seyed Hasan; Mohammadbeigi, Abolfazl; Heidari, Hadi; Ghamari, Farhad; Soltanzadeh, Ahmad

doi:10.1097/jom.0000000000001932

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…A major strength is the long-term measurement of ve pollutants with standardized and high quality sampling techniques and instruments resulting in reliable levels of airborne concentrations in the vicinity of the petrochemical plant. (57,74) and respiratory symptoms, the current study focused on these pollutants rather than other petrochemical airborne chemicals such as VOCs. Although air concentrations of gaseous pollutions were measured in a reliable way, we did not have individual exposure data and had to assume a constant level of exposure among all workers in the petrochemical plant.…”

Section: Discussionmentioning

confidence: 99%

Airborne toxic exposure and pulmonary outcomes among petrochemical complex workers

Jalilian

Mirzaei

khojasteh³

et al. 2021

Preprint

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Background Petrochemical workers are exposed to a variety of airborne toxic compounds which have been associated with increased risk for respiratory outcomes. However, long-term exposure to SO2, NO2, O3, H2S and NH3 in relation to spirometric parameters and self-reported respiratory problems is largely unknown. Methods Airborne concentration levels of SO2, NO2, O3, H2S and NH3 were collected from two fixed stations over a 3-year period in a petrochemical complex. We assessed spirometric parameters and respiratory symptoms in the petrochemical workers (n = 200) and in an unexposed group (n = 200). We calculated β-coefficients (β) and odds ratios (ORs) with 95% confidence intervals (CIs) before and after adjustment for covariates. Results The mean airborne pollution levels were 159 µg/m3 for SO2, 43 µg/m3 for NO2, 66 µg/m3 for O3, 6 µg/m3 for H2S, and 24 µg/m3 for NH3. We found a significant reduction in spirometric parameters among petrochemical workers compared to the unexposed: FEV1 (forced expiratory volume in 1s) (adjusted β -12; 95%CI -16, -7.64), FEV1/ FVC (forced vital capacity) (β -7.26; 95%CI -9.23, -5.28), and PEF (peak expiratory flow) (β -6.61; 95%CI -12, -0.76). Additionally, we observed higher adjusted risks for any respiratory symptom (OR 4.69; 95%CI 1.76, 12), mucus (OR 4.36; 95%CI 1.70, 11) and shortness of breath (OR 15; 4.95, 46) among petrochemical workers compared to the unexposed group. Conclusions Most measured airborne pollution levels were within the ambient recommendation levels. Still, long-term exposure to low level airborne pollutants, reduced FEV1, FEV1/FVC and PEF, and increased respiratory symptoms in Iranian petrochemical workers compared to unexposed controls.

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Section: Discussionmentioning

confidence: 99%

Airborne toxic exposure and pulmonary outcomes among petrochemical complex workers

Jalilian

Mirzaei

khojasteh³

et al. 2021

Preprint

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“…This study also found a significant decrease in FVC (p = 0,01) and FEV 1 (p=0,05) during the work shift among workers in urea factory. Study by Mahdinia et al 12 showed that exposure and the amount of exposure to ammonia had a significant relationship with respiratory disorders and respiratory function ( P < 0,05).…”

Section: Strength Of Associationmentioning

confidence: 97%

“…Mahdinia M et al 12 followed the subjects for five years and obtained exposure and the amount of exposure to ammonia had a significant relationship with respiratory disorders and respiratory function ( P < 0,05). Meanwhile, the other four articles did not follow their subjects for a certain period of time.…”

Section: Specificitymentioning

confidence: 99%

“…The studies population consisted of 67 male operational workers and 57 male repair and maintenance workers as exposed group and 120 male office workers of the same plant as control group. The mean concentration of ammonia in the breathing zones of the operational, repair and maintenance workers and its environmental 12 (2020) was a historical cohort study conducted on the 122 workers of four synthetic fertilizer industries in 5 years from 2015 to 2019. This study aimed to investigate respiratory disorders associated with exposure to low concentrations of ammonia.…”

Section: Of Air Years) Comparison Of Pfis Between Symptomaticmentioning

confidence: 99%

“…Respiratory function were decrease significantly in the exposure group and were lower than non exposure group (P < 0,05 ). Exposure and the amount of exposure to ammonia had a significant relationship with respiratory disorders and respiratory function ( P < 0,05) After critically assessed, there was only one article, a cohort study, conducted by Mahdinia et al 12 It was the best study to establish a causal relationship between exposure and outcome and has reliable data collection To calculate the NNH (number of patients we need to treat to harm one of them) for any odds ratio (OR) and our patient's expected event rate for this adverse event if they were not exposed to this treatment (PEER):…”

Section: Of Air Years) Comparison Of Pfis Between Symptomaticmentioning

confidence: 99%

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Bronchial Asthma Among Synthetic Fertilizer Factory Workers Exposed to Ammonia

Solihati

Ilyas

2022

IJCOM

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Background: Ammonia is colorless gaseous compound, lucid and irritating material that is water soluble with a distinctly pungent odor. About 80% of the total usage of ammonia is mainly used to produce synthetic fertilizers. One of the health problems caused by ammonia is bronchial asthma. Ammonia can act as sensitizer or irritant asthmagen depend on their properties, which increased complex interaction of inflammation, airway hyperresponsiveness, and airflow obstruction. However, the causal relationship between ammonia and bronchial asthma is still unclear, so it is necessary to look for some evidence regarding this relationship. The search for evidence also included the seven-step assessment of occupational diagnosis of diseases. Therefore, it can assist occupational medicine doctors who treat patients with bronchial asthma and with a history of ammonia exposure. Methods: The literature searching using the electronic database “PubMed”, “Scopus”, and “Cochrane” search engine. Keywords used were worker, ammonia, and bronchial asthma, ventilatory disorder, respiratory disorder. The articles were selected using the defined inclusion and exclusion criteria. The selected articles were then be critically reviewed based on etiological studies from the Oxford Center of Evidence-Based Medicine. Result: From the five literature obtained, there are differences in results. One article stated that ammonia can increase prevalence risk of bronchial asthma, and other four articles found significant associations between ammonia and reduction in the parameters of pulmonary function. Conclusion: There is a relationship between ammonia exposure and the prevalence of bronchial asthma and reduction of pulmonary function in synthetic fertilizer factory worker. But it is uncertain whether the diagnosis is occupational asthma.

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Inhalation of ammonia promotes apoptosis and induces autophagy in hepatocytes via Bax/BCl-2 and m-TOR/ATG5/LC-3bII axes

Chen,

Liu,

et al. 2024

Science of The Total Environment

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Respiratory Disorders Resulting From Exposure to Low Concentrations of Ammonia

Cited by 9 publications

References 14 publications

Airborne toxic exposure and pulmonary outcomes among petrochemical complex workers

Airborne toxic exposure and pulmonary outcomes among petrochemical complex workers

Bronchial Asthma Among Synthetic Fertilizer Factory Workers Exposed to Ammonia

Inhalation of ammonia promotes apoptosis and induces autophagy in hepatocytes via Bax/BCl-2 and m-TOR/ATG5/LC-3bII axes

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