2020
DOI: 10.1002/ajpa.24051
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Abstract: Primates display a wide range of phenotypic variation underlaid by complex genetically regulated mechanisms. The links among DNA sequence, gene function, and phenotype have been of interest from an evolutionary perspective, to understand functional genome evolution and its phenotypic consequences, and from a biomedical perspective to understand the shared and human-specific roots of health and disease. Progress in methods for characterizing genetic, transcriptomic, and DNA methylation (DNAm) variation is drivi… Show more

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Cited by 7 publications
(6 citation statements)
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References 191 publications
(253 reference statements)
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“…However, their findings can be difficult to extrapolate to species living in more complex environments (Briga & Verhulst, 2015 ), with diverse genetic background and much longer lifespan and thereby different life history strategies, such as humans (Perlman, 2016 ). Even if ageing studies of non‐human primates kept in captive conditions are increasing (Jasinska, 2020 ; Languille et al, 2012 ), the full diversity of mammalian species displaying life‐history traits and life styles similar to the ones observed in humans (e.g., whether there are socially monogamous, long‐lived, provide extensive periods of parental care or create tight social bonds with conspecifics) needs to be embraced and generalized. In addition, the study of the ageing process in the wild enables ‐ by essence ‐ to investigate the role played by the environment, an important piece of the ageing conundrum.…”
Section: Introductionmentioning
confidence: 99%
“…However, their findings can be difficult to extrapolate to species living in more complex environments (Briga & Verhulst, 2015 ), with diverse genetic background and much longer lifespan and thereby different life history strategies, such as humans (Perlman, 2016 ). Even if ageing studies of non‐human primates kept in captive conditions are increasing (Jasinska, 2020 ; Languille et al, 2012 ), the full diversity of mammalian species displaying life‐history traits and life styles similar to the ones observed in humans (e.g., whether there are socially monogamous, long‐lived, provide extensive periods of parental care or create tight social bonds with conspecifics) needs to be embraced and generalized. In addition, the study of the ageing process in the wild enables ‐ by essence ‐ to investigate the role played by the environment, an important piece of the ageing conundrum.…”
Section: Introductionmentioning
confidence: 99%
“…However, their findings can be difficult to extrapolate to species living in more complex environments (Briga and Verhulst 2015), with diverse genetic background and much longer lifespan and thereby different life history strategies, such as humans (Perlman 2016). Even if studies of non-human primates kept in captive conditions are increasing (Languille et al 2012;Jasinska 2020), the full diversity of mammalian species displaying life-history traits and life styles similar to the ones observed in humans (i.e. whether there are socially monogamous, long-lived, provide extensive periods of parental care or create tight social bounds with conspecifics) is yet to be considered.…”
Section: Introductionmentioning
confidence: 99%
“…Currently we largely relied on the GWAS catalog annotation since manually curating 14,529 SNPs will require an extraordinary amount of effort and in some cases impossible without full access to the original genotype/phenotype data; Second, some eQTL calls may not be robust; although we show they are largely consistent across different studies, there were some apparent variations in eQTL calling across studies; Third, eQTLs only indicate association between genetic variants and gene expression, it remains unknown if the eQTLs are actually involved in regulating the gene expression; this becomes even more complicated due to the fact that multiple mapping among variants-gene expression exists. For instance, rs602633 (Pilling et al, 2017) (Giambartolomei et al, 2014), S-PrediXcan was developed to perform transcriptome-wide genome association to identify possible gene expression associated with the phenotypic traits (Jasinska, 2020), and transcriptome-wide summary statistics-based Mendelian randomization method TWMR was developed to use multiple SNPs as instruments and multiple gene expression traits as exposures to infer if the causal link between instruments and outcome was mediated by exposures (Porcu et al, 2019). Although these methods are helpful to test the potential involvement of gene expression in causing phenotypic trait, they all require GWAS summary statistics and therefore limited their use in this study.…”
Section: Discussionmentioning
confidence: 99%