Resolution of patch-type granuloma annulare lesions after biopsy

A granuloma annulare case without annular lesion: A rare variant

“…In time, it gains annular character with regress in the middle part, continues to expand to the center and can form plaques by combining [9]. Our case had extensive papular lesions which were dense in the extensors of both arms and around the elbow.…”

“…In addition, topical or intralesional steroids, topical imiquimod, cryotherapy, intralesional interferon, hydroxychloroquine, dapsone, isotretinoin, PUVA, CO2 laser and even TNF-α inhibitors are among treatment options [4,9].…”

Patch-type granuloma annulare: a case report

“…Resolution of patch-type GA after biopsy has also been reported 7 and some cases show spontaneous resolution. 6,7 Systemic therapy is usually unnecessary due to the relatively limited involvement and asymptomatic nature of the lesions.…”

“…In the majority of cases, no symptoms were reported. [4][5][6][7][8][9] So far, the pathogenesis of GA is still unknown. It has been suggested that this condition is idiopathic and it can be seen more frequently in female patients.…”

“…Some authors suggest that GA is secondary to a delayed-type hypersensitivity reaction caused by an unknown antigen, which would cause connective tissue degradation and structural damage to elastic fibers and collagen. [3][4][5][6][7][8][9][10] Moreover, drugs, sun exposure, insect bites, viral infections, cancer or trauma are also considered to be associated factors. 2,4,9 The differential diagnosis of patch-type GA includes morphea, erythema annulare centrifugum, mycosis fungoides, parapsoriasis, leprosy, sarcoidosis, and Lyme disease.…”