2012
DOI: 10.1590/s0066-782x2012005000107
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Abstract: Background: The dual antiplatelet therapy with acetylsalicylic acid (ASA) and clopidogrel is the cornerstone of treatment for patients undergoing angioplasty with coronary stent implantation. However, some of these patients, despite the use of aspirin and clopidogrel, are not effectively anti-aggregated, a phenomenon known as resistance to antiplatelet agents. Its prevalence, as well as the conditions associated with it, is unknown in our country.

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Cited by 9 publications
(7 citation statements)
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“…The frequency of suboptimal PA inhibition observed during this study (14.9%) was similar to that previously reported (2224). Interestingly, none of the patients receiving ticagrelor had inadequate PA inhibition.…”
Section: Discussionsupporting
confidence: 92%
“…The frequency of suboptimal PA inhibition observed during this study (14.9%) was similar to that previously reported (2224). Interestingly, none of the patients receiving ticagrelor had inadequate PA inhibition.…”
Section: Discussionsupporting
confidence: 92%
“…Laboratory ASA resistance is defined as the inability of therapeutic doses of ASA to inhibit platelet aggregation, which is a primary measurement of platelet function or a failure to reduce TXA 2 [ 17 ]. The incapacity of clopidogrel to inhibit platelet aggregation measured at the laboratory is known as clopidogrel resistance [ 18 ]. As Sibbing et al .…”
Section: Methodsmentioning
confidence: 99%
“…Patients with coronary ischemia who are nonresponders to clopidogrel and aspirin are at greater risk of subsequent ischemic vascular events and death [ 14 ]. Several studies have shown that reduced response to clopidogrel ranges from 4.8–51% [ 15 , 16 ]. Our previous studies showed that the incidence of CR in the Chinese population was 40%, and CR was associated with RIS during 6 months after stroke [ 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%