Resistência a anti-helmínticos em ovinos da região de Londrina - Paraná – Brasil

Filho, Luiz Fernando Coelho da Cunha; Pereira, Ademir Benedito da Luz; Yamamura, Milton Hissashi

doi:10.5433/1679-0359.1998v19n1p31

Cited by 14 publications

(6 citation statements)

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“…O parasito do gênero Haemonchus foi o mais prevalente nas coproculturas pós-tratamento, tanto em ovinos quanto em caprinos. Esse resultado está de acordo com os resultados de outros levantamentos feitos no estado do Ceará (MELO et al, 1998;BEVILAQUA & MELO, 1999;VIEIRA & CAVALCANTE, 1999), no nordeste brasileiro (CHARLES et al, 1989;BARRETO & SILVA, 1999), na região sul do Brasil (RAMOS et al, 1999;FARIAS et al, 1997;CUNHA-FILHO, 1999) e na América Latina (WALLER et al, 1996). A resistência acontece geralmente em áreas com verões chuvosos, e onde o parasito H. contortus é endêmico (WALLER et al, 1995).…”

Section: Discussionunclassified

Nematódeos resistentes a anti-helmíntico em rebanhos de ovinos e caprinos do estado do Ceará, Brasil

et al. 2003

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O controle do parasitismo por nematódeos gastrintestinais é feito basicamente com a utilização de anti-helmínticos. Falhas no controle são o primeiro sinal do aparecimento de resistência anti-helmíntica. A real situação da prevalência da resistência anti-helmíntica, em fazendas comerciais de criação de ovinos e caprinos no Brasil, é desconhecida. Esse experimento teve como objetivo, estimar a ocorrência de resistência ao oxfendazol, levamisol e ivermectina em propriedades comerciais de criação de ovinos e caprinos, na região do médio e baixo Jaguaribe, através do teste de redução na contagem de ovos nas fezes acompanhados de coproculturas. O trabalho foi realizado em 25 criações, sendo 16 de ovinos, 7 de caprinos e uma de ovinos e caprinos. Os dados obtidos foram analisados pelo programa estatístico RESO (1989). A prevalência de nematódeos resistentes ao oxfendazol, levamisol e ivermectina em ovinos foi de 88%, 41% e 59%, e em caprinos de 87,5%, 75% e 37,5%, respectivamente. Observou-se que o gênero Haemonchus foi o mais prevalente na população resistente a todos os anti-helmínticos, tanto em ovinos quanto em caprinos, seguido de Trichostrongylus e Oesophagostomum.

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Section: Discussionunclassified

Nematódeos resistentes a anti-helmíntico em rebanhos de ovinos e caprinos do estado do Ceará, Brasil

et al. 2003

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“…For the albendazole + levamizole + ivermectin combination, only one population of T. colubriformis was considered resistant to this medication, whereas the remaining nematode populations evaluated, T. colubriformis, T. axei, C. curticei, S. papillosus and O. columbianum, were diagnosed as susceptible to this compound. Although albendazole, levamizole and ivermectin were not tested separately, studies conducted worldwide with benzimidazoles reinforce the inefficacy of this antiparasitic class against helminths parasitizing sheep and goats (Cunha Filho et al, 1998;Melo et al, 1998;Sczesny-Moraes et al, 2010;Duarte et al, 2012;Mahineu et al, 2014). However, there are several reports of helminthic resistance against levamizole, the active principle in ruminants (Souza and Thomas-Soccol, 1997;Souza and Thomas-Soccol, 1997), and susceptible populations remain, depending on the region (Lima et al, 2010;Duarte et al, 2012).…”

Section: Studiesmentioning

confidence: 99%

Susceptibility of helminth species parasites of sheep and goats to different chemical compounds in Brazil

Bichuette

Lopes

Gomes

et al. 2015

Small Ruminant Research

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A total of 160 sheep and 160 goats were necropsied to evaluate the degrees of susceptibility or resistance of different helminth species to 0.2 mg/kg ivermectin (subcutaneous route), 0.2 mg/kg moxidectin (subcutaneous route), 100 mg/kg trichlorfon (administered orally) and the combination of 5 mg/kg albendazole + 7.5 mg/kg levamizole + 0.2 mg/kg ivermectin (administered orally). To achieve this objective, eight experiments were performed, four with each animal species. In each experiment, naturally infected sheep or goats were divided into five groups with eight individuals each, as follows: T01, untreated control; T02, trichlorfon; T03, ivermectin; T04, moxidectin; and T05, albendazole + levamizole + ivermectin, based on average counts of eggs per gram of feces (EPG) before treatment (experimental dates −3, −2 and −1). Seven days post-treatment (DPT), all animals were euthanized and necropsied for the recovery of helminth burdens. Based on the obtained results, it is possible to conclude that the resistance of some helminth species parasitizing sheep and goats is different for the tested chemical groups. Ivermectin, at 0.2 mg/kg dosage, presented inferior anthelmintic efficacy against some of these parasites. Of these species, populations of Haemonchus contortus, followed by Trichostrongylus colubriformis, Cooperia curticei and Oesophagostomum columbianum, exhibited the greatest resistance to the aforementioned chemical compound, whereas Trichostrongylus axei displayed higher susceptibility to ivermectin. For moxidectin (0.2 mg/kg), 75% of all H. contortus populations were considered resistant to this drug, whereas all populations of T. colubriformis, T. axei, C. curticei and O. columbianum were susceptible. Trichlorfon and albendazole + levamizole + ivermectin were effective against the analyzed nematode populations, except against one strain of H. contortus and one strain of T. colubriformis. All three Strongyloides papillosus populations evaluated were susceptible to the tested formulations, except for moxidectin, as this compound presented low efficacy indices against all populations of this helminth species.

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“…Os primeiros registros de resistência a anti-helmínticos surgiram nos anos 60, sendo relatado no Brasil, em primeiro lugar no Rio Grande do Sul por Santos & Gonçalves (1967/68), que constataram a resistência de Haemonchus contortus ao Thiabendazole. Após esse relato, vários autores descreveram uma generalização do problema da resistência em criações de ovinos nas diversas regiões do Brasil: Sul (Santiago & Costa 1979, Soccol et al 1996, Cunha-Filho et al 1998, Sudeste (Verissímo et al 2002), Nordeste (Vieira et al 1989, Melo et al 1998, Barreto & Silva 1999, Barreto et al 2002, Bispo et al 2002, entre outros.…”

Section: Introductionunclassified

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Sczesny-Moraes

Bianchin²,

Silva³

et al. 2010

Pesq. Vet. Bras.

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ABSTRACT.-Sczesny-Moraes E.A., Bianchin I., Silva K.F., Catto J. Among the methods of control of gastrointestinal worms in sheep, the use of chemicals is the most common. However, the continued, and indiscriminate, use of these products has selected populations of resistant helminths to anthelmintics, a phenomenon reported in the whole world. This study aimed to identify the species of gastrointestinal parasites and diagnose the status of anthelmintic resistance in sheep in the State of Mato Grosso do Sul Brazil. Feacal egg count reduction tests (FECRT) were performed in flocks of sixteen farms, and the seven formulations used contained the following pharmacological bases: Albendazole, Ivermectin, Levamizol, Trichlorfon, Moxidectin, Closantel and one containing the first three in association. The species identified at necropsy, in adult sheep, were: Haemonchus contortus, Trichostrongylus colubriformis, Cooperia curticei, C. punctata, C. pectinata and Oesophagostomum columbianum, in order of prevalence. The formulations containing Albendazole and Ivermectin did not show efficacy in reducing the EPG in the flocks tested, with average reductions of 0.7 and -19.6%, respectively. Closantel presented an average efficacy of 6.7%; Levamisolee, Moxidectin and Trichlorfon, 28.7, 26.8 and 65% respectively, the combination of three bases (Albendazole, Ivermectin and Levamizol), an average efficacy of 55.8 %. The average percentages of infective larvae recovered in the faecal cultures, pre and post treatment were similar, indicating that resistance to the bases tested is present in all species cited, to a greater or lesser degree. The two genera predominantly resistant are Haemonchus sp., with 86.9%, followed by Trichostrongylus sp., with an average of 47.5%, Strongyloides sp. 33.6%, Oesophagostomum sp.

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Resistência a anti-helmínticos em ovinos da região de Londrina - Paraná – Brasil

Cited by 14 publications

References 0 publications

Nematódeos resistentes a anti-helmíntico em rebanhos de ovinos e caprinos do estado do Ceará, Brasil

Nematódeos resistentes a anti-helmíntico em rebanhos de ovinos e caprinos do estado do Ceará, Brasil

Susceptibility of helminth species parasites of sheep and goats to different chemical compounds in Brazil

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

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