2018
DOI: 10.1101/265520
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Abstract: In recent years, effective treatment of infections caused by Acinetobacter baumannii has become challenging due to the ability of the bacterium to acquire or up-regulate antimicrobial resistance determinants. Two component signal transduction systems are known to regulate expression of virulence factors including multidrug efflux pumps. Here, we investigated the role of the AdeRS two component signal transduction system in regulating the AdeAB efflux system, determined whether AdeA and/or AdeB can individually… Show more

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Cited by 3 publications
(1 citation statement)
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“…As the population ages, the proportion of the elderly population gradually increases. On the one hand, the elderly have declining physiological function, reduced resistance and reaction ability to varying degrees, resulting in atypical clinical symptoms, rapid changes in disease status, long course of the disease, and the slow recovery of prognosis; not only that, there are many adverse drug reactions in the elderly, which are more likely to cause respiratory tract, urinary tract, blood flow and biliary tract infections [9,10]; On the other hand, some elderly patients lack correct understanding of the disease, which can easily aggravate the mental burden and cause mental trauma and pain, which is not conducive to the prognosis of the disease. Therefore, to understand the potential risk factors of elderly CRO infection and prognosis in the eastern region of Heilongjiang Province, and to better assist in the prevention and control of clinical treatment, this study collected clinical data of elderly patients in a hospital in Heilongjiang Province, and screened the potential risk factors of CRO hospital infection and prognosis.…”
Section: Cro Mainly Includes Carbapenem-resistant Enterobacteriaceae(mentioning
confidence: 99%
“…As the population ages, the proportion of the elderly population gradually increases. On the one hand, the elderly have declining physiological function, reduced resistance and reaction ability to varying degrees, resulting in atypical clinical symptoms, rapid changes in disease status, long course of the disease, and the slow recovery of prognosis; not only that, there are many adverse drug reactions in the elderly, which are more likely to cause respiratory tract, urinary tract, blood flow and biliary tract infections [9,10]; On the other hand, some elderly patients lack correct understanding of the disease, which can easily aggravate the mental burden and cause mental trauma and pain, which is not conducive to the prognosis of the disease. Therefore, to understand the potential risk factors of elderly CRO infection and prognosis in the eastern region of Heilongjiang Province, and to better assist in the prevention and control of clinical treatment, this study collected clinical data of elderly patients in a hospital in Heilongjiang Province, and screened the potential risk factors of CRO hospital infection and prognosis.…”
Section: Cro Mainly Includes Carbapenem-resistant Enterobacteriaceae(mentioning
confidence: 99%