Resistance mechanisms for Gram-negative bacteria-specific lipopeptides, turnercyclamycins, differ from that of colistin
Albebson L. Lim,
Bailey W. Miller,
Zhenjian Lin
et al.
Abstract:Turnercyclamycin A and B lipopeptides exhibit Gram-negative bacteria-specific toxicity. This includes CDC urgent threat organisms such as multidrug-resistant
Acinetobacter baumannii
. Like the last-line agent colistin, turnercyclamycins interact with the lipopolysaccharide (LPS) pathway, but they remain active against clinical isolates that are colistin resistant. Here, we aimed to determine why turnercyclamycins A and B show little cross-resistance with colistin despite some potential … Show more
This review highlights the discovery of functional microbial natural products from diverse niches. Leveraging the biosynthetic capabilities of microbes in organismic interactions is crucial for tackling antimicrobial resistance.
This review highlights the discovery of functional microbial natural products from diverse niches. Leveraging the biosynthetic capabilities of microbes in organismic interactions is crucial for tackling antimicrobial resistance.
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