Resistance exercise recovery morphology and AQP1 expression in denervated soleus muscle of Wistar rats

Lovison, Keli; Vieira, Lizyana; Kunz, Regina Inês; Scarton, Suellen Ribeiro da Silva; Antunes, Juliana Sobral; Karvat, Jhenifer; Peretti, Ana Luiza; Bertolini, Gladson Ricardo Flôr; Brancalhão, Rose Meire Costa; Beu, Célia Cristina Leme; Ribeiro, Lucinéia de Fátima Chasko

doi:10.6063/motricidade.11788

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…In this sense, the most diverse therapeutic means are used to accelerate remobilization, and among them are physical exercises. Physical exercises have many benefits in the restoration of morphological and functional muscle parameters such as mass gain and consequently the ability to generate strength (Brandão et al, 2017;Koike et al, 2018;Lovison et al, 2018;Peretti et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Morphological effects of whole‐body vibration on remobilization of the tibialis anterior muscle of Wistar rats

Zazula

Wutzke

Costa

et al. 2020

The Anatomical Record

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Therapeutic immobilization is a common treatment for the locomotor system; however, it causes loss of muscle due to disuse, leading to protein degradation and generating atrophy of muscle cells, ultimately changing functionality. In this sense, it is important for remobilization to be initiated early and performed with appropriate therapeutic strategies that enable tissue and functional recovery. One method of remobilization is physical exercise, among which whole body vibration (WBV) has been highlighted and mainly applied in people with reduced mobility. However, there are gaps on the morphological effects WBV has on muscle tissue, so in this study we analyzed the histomorphometry of the tibialis anterior muscle (TA) of Wistar rats remobilized using WBV. For the experiment, 32 male Wistar rats were used and divided into four groups (n = 8/group). Groups consisted of: control (CG), immobilized (IG), immobilized and remobilized freely (FG), and immobilized and remobilized with WBV (WG). After the experimental period, the TA was collected and processed for analysis in light microscopy. When compared to the control group, significant morphological changes were observed, which characterize muscle atrophy and reduction of all histomorphometric parameters of the TA of the immobilized animals. Remobilized animals showed improvement in all parameters, and the WBV was not different from the free remobilization, except for the reduction of central nuclei, which can be related to acceleration of the process of tissue regeneration. Thus, we can conclude that the WBV can have an impact on the acceleration of the muscle regenerative process, and may be beneficial in people with reduced mobility.

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Section: Introductionmentioning

confidence: 99%

Morphological effects of whole‐body vibration on remobilization of the tibialis anterior muscle of Wistar rats

Zazula

Wutzke

Costa

et al. 2020

The Anatomical Record

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“…No significant loss of muscle mass is seen in exercise control group, however, there is some amount of shrinkage in muscle diameter that could have occurred due to sarcomere length alteration so as to accommodate muscle mass development. Treatment with M. oleifera leaf extract alone and in association with exercise attenuated muscle atrophy and may have stimulated muscle mass development [24] , [26] , [27] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera leaf extract on exercise and dexamethasone-induced functional impairment in skeletal muscles

Barodia

Cheruku

Kanwal

et al. 2022

Journal of Ayurveda and Integrative Medicine

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Background Chronic administration of steroids like dexamethasone produces symptoms including weight loss and skeletal muscle dysfunction. Similar events are reported in chronic or high-intensity exercises, that can lead to fatigue and muscle damage. Objective In the present study, the effect of Moringa oleifera leaf extract was evaluated against dexamethasone (Dex) and exercise (Exe)-induced muscle changes in rats. Materials and methods Six groups each containing 6 rats, namely normal, Dex control, Exe Control, Dex + M. oleifera leaf extract (300mg/kg p.o. ), Dex + Exe, Dex + Exe + M. oleifera leaf extract were assessed in the study. Dex was administered at 0.6 mg/kg i.p. daily for 7 days. Exercise was given for a total of 10 days after 30 minutes of dosing using treadmill equipment for 900 seconds at speed 18 m/min. Animals were assessed for variation in body weight, muscular endurance using treadmill, locomotor activity using actophotometer, motor coordination using rotarod on day zero, and day seven. Hemidiaphragm of rats were isolated and used for evaluation of the glucose uptake. Gastrocnemius muscle was isolated and subjected to hematoxylin and eosin staining. Results Dex and Exe control animals showed a significant decrease in skeletal muscle activity when compared to normal control animals in the actophotometer test. Improvement in endurance were seen in Dex + M. oleifera leaf extract, and Dex + exercise + M. oleifera leaf extract groups compared to Dex control group. Improvement in locomotor activity was seen in Dex group subjected to exercise and was significant when treated with M. oleifera leaf extract. Histology reports were in accordance with the functional parameters. Conclusion M. oleifera leaf extract supplemented with exercise showed a reversal in the dexamethasone-induced functional impairment in skeletal muscles.

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“…A vertical wooden staircase was used, with 67 iron steps, 1.18 m high, 20.5 cm wide, and 60º inclination. At the top of the staircase, a box, 20x20 cm high and wide, was positioned to rest the animals between the series, with an interval of 60 seconds 12 .…”

Section: Treatment Protocolmentioning

confidence: 99%

Morphometric aspects of the articular cartilage of rats treated with low-level laser therapy and exercise in a rheumatoid arthritis model

et al. 2022

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Introduction: Rheumatoid arthritis (RA) is classified as an autoimmune, chronic disease affecting diarthrodial joints and periarticular structures. Objective: To evaluate whether low-intensity laser treatment (LLLT) and/or exercise reduce the deleterious effects of tissue in a rheumatoid arthritis model. Methods: 128 rats were divided into two inflammatory periods: acute (7 days) and chronic (28 days) and subdivided into control, injury and treatment. The protocol with Freund's Complete Adjuvant was used in two inoculations, one intradermal and one intraarticular in the tibiofemoral joint, the control animals received saline solution. For treatment, LLLT 660 nm, 5 J/cm² was used in the sensitized joint and climbing exercise in stairways with an overload of 100 grams. After the experimental period, the animals were euthanized and the joints were prepared for morphometric analysis of the total thickness, superficial, deep, and cellular density of the articular cartilage. Generalized Linear Models with Sidak post-test were chosen. Results: The control group was found to be different from the lesion group with greater joint cartilage thickness, and the animals treated with exercise alone increased the joint cartilage compared to the control group. Conclusion: The animals treated with laser association and exercise showed improvement in the morphometric aspects of the articular cartilage.

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Resistance exercise recovery morphology and AQP1 expression in denervated soleus muscle of Wistar rats

Cited by 9 publications

References 28 publications

Morphological effects of whole‐body vibration on remobilization of the tibialis anterior muscle of Wistar rats

Morphological effects of whole‐body vibration on remobilization of the tibialis anterior muscle of Wistar rats

Effect of Moringa oleifera leaf extract on exercise and dexamethasone-induced functional impairment in skeletal muscles

Morphometric aspects of the articular cartilage of rats treated with low-level laser therapy and exercise in a rheumatoid arthritis model

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