Résistance bactérienne : états des lieux au Maroc

Serragui, Samira; Derraji, Soufiane; Mahassine, F.; Cherrah, Yahia

doi:10.48408/imist.prsm/mm-v35i3.2939

Cited by 2 publications

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“…The percentage of physicians prescribing antibiotics in chronic wounds was 100%, and only 61% used professional bacteriological sampling, where the most used antibiotic was penicillin M, with a rate in Canada is 53% [11], and 53% in France [35]. Through previous studies conducted from 2014 to 2022, in 2014 in a study on antibiotic prescribing before and during hospitalization in children under 5 years of age, the percentage of antibiotic prescriptions was 86.5%.…”

Section: Discussionmentioning

confidence: 99%

“…The worldwide consumption of antibiotics has increased by 65% between 2000 and 2015 [10] and surveys have shown that antibiotics consume more than 25% of the total drug consumption of Moroccan hospitals. In addition, there is also an abuse in the prescription of antibiotic therapy, their sale in self-medication in pharmacies also promotes the abuse of these drugs and the increase in the rate of resistance, these bad habits in prescribing and the increase in antibiotic consumption, result in a change in the resistance profiles of bacterial species and the emergence of multiresistant bacteria [11].…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic prescription in Morocco, national data: Meta-analysis

Al-Selwi¹,

Barkat²

2022

Journal of Pharmaceutical Negative Results

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Antibiotics are the most prescribed medication and the misprescribing of antibiotics is a public health problem worldwide.Objective: Conduct a meta-analysis to determine the prevalence of antibiotic prescribing, assess the quality of prescribing and identify factors of inappropriate prescribing in Morocco.Materials and Methods: 92 articles found in databases (35, 42, 55 and 50, in Elsevier, PubMed, Google Scholar and Other engines respectively).Results: In studies carried out in 2009 and 2011, on the evaluation of the use of antibiotics by dermatologists we noticed that beta-lactams were the most commonly prescribed: 53%. A survey on the use of generic antibiotics or pediatric service used beta-lactam, 63%. The prescription of antibiotics in the department of burns and plastic surgery was 65%. These results are important to explain a resistance of betalactamins to different offences and the constitution of beta-lactamase should be searched. A study conducted in 2018 in Rabat, 90 physicians and surgeon’s specialists, 91.7% of them prescribed antibiotics. Through previous studies from 2014 to 2022, a children’s under 5 years of age with severe clinical pneumonia, 86.5% received antibiotics. In another study on the evaluation of antibiotic prescriptions in the emergency department, amoxicillin was used in 31.4%. Also in a study on the evaluation of antibiotic prescriptions in pediatric emergency departments, 3rd generation cephalosporins were used in 69% of cases. A study of antibiotic self-medication parents knew that antibiotics are subject to a prescription and 72.1% knew that antibiotics had side effects on children, and in this study amoxicillin was used the most at 46.6%, and it is one of the most widely used antibiotics in Morocco, despite the development of numerous resistances. In studies conducted in 2009, 2016, and 2017 on preventive antibiotic use is still prescribed (22%, 17.7% and 7.14%). Antibiotic prescriptions were not limited only to physicians, but studies indicated that 10.9% of them were prescribed by pharmacists and in 2022 the percentage increased to 42%.Conclusion: This meta-analysis on studies and research of antibiotic prescribing: national data in the last 13 years in Morocco, the deficiencies found in antibiotic prescribing require the establishment of national recommendations to reduce misprescribing.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibiotic prescription in Morocco, national data: Meta-analysis

Al-Selwi¹,

Barkat²

2022

Journal of Pharmaceutical Negative Results

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Phytochemical Screening and In vitro Antioxidant, Antibacterial, and Antihemolytic Activities of Putoria calabrica Leaf Extracts

Mekhoukh

Chougui

Bellik

2023

CBC

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Background: : Putoria calabrica is a common Mediterranean plant used topically in folk medicine for medical purposes. The aim of this study is to evaluate the in vitro antioxidant, antibacterial, and antihemolytic properties of Putoria calabrica leaf extracts. Methods: Total phenol content (TPC), total flavonoid content (TFC), and condensed tannins content (CTC) were determined spectrophotometrically. The antioxidant activity was tested using TAC, DPPH, ABTS, and FRAP assays. Agar diffusion method was used to determine the antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. Anti-hemolytic activity was evaluated by the measurement of erythrocytes turbidity and extracellular hemoglobin concentration using AAPH method. Results: Methanol was the optimal solvent to extract the bioactive components with the highest extraction yield (30.11 ± 0.42%), TPC (142.11 ± 4.04 mg GAE/g dry extract) and TFC (29.16 ± 0.99 mg QrE/g dry extract). In terms of antioxidant activity, methanol extract was the most effective against ABTS free radical (IC50 = 5.02 ± 0.13 mg/ml) and FRAP (A0.5 = 2.91 ± 0.09 mg/ml). While, acetone extract showed the highest TAC (214.05 ± 8.74 mg GAE/g dry extract) and DPPH scavenging activity (IC50 = 1.94 ± 0.02 mg/ml). The strongest antimicrobial effect at a concentration of 10.24 mg/well was observed with acetone extract against P. aeruginosa (22.52 ± 0.60 mm) and C. albicans (17.33 ± 0.41 mm). While, methanol extract was the most active against S. aureus (17.31 ± 0.98 mm). Aqueous extract showed a good capacity to protect erythrocytes from oxidative damage by preventing their hemolysis and the oxidation of hemoglobin induced by AAPH. Conclusion: P. calabrica leaves could have a great importance as a source of therapeutic bioactive compounds.

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Résistance bactérienne : états des lieux au Maroc

Cited by 2 publications

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Antibiotic prescription in Morocco, national data: Meta-analysis

Antibiotic prescription in Morocco, national data: Meta-analysis

Phytochemical Screening and In vitro Antioxidant, Antibacterial, and Antihemolytic Activities of Putoria calabrica Leaf Extracts

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