Residential Radon and Lung Cancer among Never-Smokers in Sweden

Lagarde, Frédéric; Axelsson, Gösta; Damber, Lena; Mellander, Hans; Nyberg, Fredrik; Pershagen, Göran

doi:10.1097/00001648-200107000-00009

Cited by 85 publications

(51 citation statements)

References 28 publications

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“…Lagarde et al (2001) conducted a casecontrol study of lung cancer among nonsmokers in Sweden to examine the effect of residential radon exposure and found an ERR coefficient that was similar to the overall risk estimate obtained from the metaanalyses of domestic radon studies. Recently, Wang et al (2002b) have reported the results of a case-control study of lung cancer incidence during January 1994 to April 1998 in a high residential radon area of Gansu Province in China.…”

Section: Introductionmentioning

confidence: 65%

The cancer epidemiology of radiation

2004

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Section: Introductionmentioning

confidence: 65%

The cancer epidemiology of radiation

2004

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“…Among them, most were excluded after abstract because they were occupational studies on miners, no case control studies, no relevant exposure or endpoint, and reviews. After assessing the full-text of the 38 relevant articles, we identified 22 eligible studies for meta-analysis (Blot et al, 1990;Schoenberg et al, 1990;Pershagen et al,1992Pershagen et al, , 1994Alavanja et al, 1994Alavanja et al, , 1999Létourneau et al, 1994;Auvinen et al, 1996;Ruosteenoja et al, 1996;Darby et al, 1998;Field et al, 2000;Sobue et al, 2000;Lagarde et al, 2001;Pisa et al, 2001;Barros-Dios et al, 2002;Wang et al, 2002;Baysson et al, 2004;Bochicchio et al, 2005;Wichmann et al, 2005;Sandler et al, 2006;Thompson et al, 2008;Wilcox et al, 2008). Seven studies were excluded for previous mete-analysis (Lubin and Boice, 1997;Pavia et al, 2003) and combined analysis in Europe, North America or China Darby et al, 2005;Krewski et al, 2005;Wang et al, 2005;Darby et al, 2006).…”

Section: Literature Searchmentioning

confidence: 99%

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Zhang¹,

Sun²,

Dong³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results. Methods: We therefore performed a meta-analysis of relevant published casecontrol studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed-or random-effects models. Subgroup and dose-response analyses were also performed. Results: We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/m 3 increment in residential radon exposure was associated with a significant 7% increase in lung cancer risk. Subgroup analysis displayed a more pronounced association in the studies conducted in Europe. Studies restricted to female or non-smokers demonstrated weakened associations between exposure and lung cancer. Conclusions: This metaanalysis provides new evidence supporting the conclusion that residential exposure to radon can significantly increase the risk of lung cancer in a dose-response manner.

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“…3 Cigarette smoking is attributable to approximately 85-90% of all lung cancer, and certain environmental and occupational exposures, such as asbestos and radon, have also been linked to lung cancer development. 4,5 The incidence of lung cancer is rising in women and declining in men as a result of changed smoking behavior. 6 The changing histological patterns in lung cancer probably relate to changes in the composition of cigarettes.…”

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Inherited predisposition to early onset lung cancer according to histological type

Hemminki

2004

Intl Journal of Cancer

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The role of hereditary factors in lung cancer is less well understood than in many other human neoplastic diseases. We used a nation-wide family dataset to search for evidence for a genetic predisposition in lung cancer. The Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0-to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR) and 95% confidence limits (CI) were calculated for age-specific familial risks in offspring by parental or sibling proband, separately. A Kappa test was used to examine the association between familial risk and histology. Compared to the rate of lung cancers among persons without family history, a high risk by parental family history in adenocarcinoma (2.03) and large cell carcinoma (2.14) was found, and only a slightly lower risk was found among patients with squamous cell carcinoma (1.63) and small cell carcinoma (1.55). Among siblings, an increased risk was shown for concordant adenocarcinoma and small cell carcinoma at all ages and for all histological types when cancer was diagnosed before age 50. At young age, risks between siblings were higher than those between offspring and parents. The present data suggest that a large proportion of lung cancers before age 50 years appears to be heri- Lung cancer is the most common fatal cancer in the world, 1,2 and in Sweden it ranks fourth in incidence after prostate, colorectal and squamous cell skin cancer in men and after breast, colorectal and endometrial cancer in women. 3 Cigarette smoking is attributable to approximately 85-90% of all lung cancer, and certain environmental and occupational exposures, such as asbestos and radon, have also been linked to lung cancer development. 4,5 The incidence of lung cancer is rising in women and declining in men as a result of changed smoking behavior. 6 The changing histological patterns in lung cancer probably relate to changes in the composition of cigarettes. 7,8 As only 10% of cigarette smokers develop lung cancer, 9 it is suggested that genetic factors may be a contributing factor. Segregation analysis of lung cancer also supports the existence of heritable effects. 10 -12 In families of smoking probands, the data have suggested Mendelian dominant or codominant effects; in families of nonsmoking probands either no Mendelian or, particularly in lung cancers diagnosed before age 60 years, Mendelian codominant models have provided the best fits.Studies in molecular biology have elucidated the role of genetic factors in modifying an individual's risk for lung cancer. 13,14 There is increasing evidence that genes coding for carcinogen metabolism and DNA repair contribute to familial aggregation of lung cancer. [15][16][17][18] The early reports on genetic influences in lung cancer susceptibility appeared in the early 1980s and showed that firstdegree nonsmoking relatives of lung cancer patients had an increased risk of lung cance...

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Residential Radon and Lung Cancer among Never-Smokers in Sweden

Cited by 85 publications

References 28 publications

The cancer epidemiology of radiation

The cancer epidemiology of radiation

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Inherited predisposition to early onset lung cancer according to histological type

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