Reshaping hypoxia and silencing CD73 via biomimetic gelatin nanotherapeutics to boost immunotherapy

Yuan, Cong-Shan; Teng, Zhuang; Yang, Shuang; He, Zheng; Meng, Lingyang; Chen, Xiguang; Liu, Ya

doi:10.1016/j.jconrel.2022.09.029

Cited by 15 publications

(16 citation statements)

References 50 publications

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Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

“…By adjusting the properties and structure of gelatin, controlled drug release can be achieved. This characteristic has led to the widespread use of gelatin in drug delivery systems, particularly in local treatments and slow-release drug applications . Currently, gelatin serves as a natural biomaterial widely used in the preparation of various biological scaffolds, sponges, repair materials, and fillers. , Due to its malleability and biocompatibility, gelatin finds extensive use in plastic surgery and cosmetic procedures.…”

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

“…Yuan et al designed GNPs camouflaged with cancer cell membranes (CSG@B16F10) to codeliver the oxygen generator enzyme catalase (CAT) and CD73 siRNA, thereby enhancing tumor oxygenation and alleviating T-cell immunosuppression mediated by the CD73-ADO pathway. 162 The fabricated biomimetic nanoparticles effectively exploited the retention of cancer cell membrane proteins for immune evasion and homologous targeting. GNPs responsive to MMP gradually degraded to accelerate the release of the preloaded gene.…”

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

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Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Jia,

Fan,

Chen

et al. 2024

Biomacromolecules

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As a biodegradable and biocompatible protein derived from collagen, gelatin has been extensively exploited as a fundamental component of biological scaffolds and drug delivery systems for precise medicine. The easily engineered gelatin holds great promise in formulating various delivery systems to protect and enhance the efficacy of drugs for improving the safety and effectiveness of numerous pharmaceuticals. The remarkable biocompatibility and adjustable mechanical properties of gelatin permit the construction of active 3D scaffolds to accelerate the regeneration of injured tissues and organs. In this Review, we delve into diverse strategies for fabricating and functionalizing gelatin-based structures, which are applicable to gene and drug delivery as well as tissue engineering. We emphasized the advantages of various gelatin derivatives, including methacryloyl gelatin, polyethylene glycolmodified gelatin, thiolated gelatin, and alendronate-modified gelatin. These derivatives exhibit excellent physicochemical and biological properties, allowing the fabrication of tailor-made structures for biomedical applications. Additionally, we explored the latest developments in the modulation of their physicochemical properties by combining additive materials and manufacturing platforms, outlining the design of multifunctional gelatin-based micro-, nano-, and macrostructures. While discussing the current limitations, we also addressed the challenges that need to be overcome for clinical translation, including high manufacturing costs, limited application scenarios, and potential immunogenicity. This Review provides insight into how the structural and chemical engineering of gelatin can be leveraged to pave the way for significant advancements in biomedical applications and the improvement of patient outcomes.

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Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

See 1 more Smart Citation

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Jia,

Fan,

Chen

et al. 2024

Biomacromolecules

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“…In aims to overcome the tumor's pervasive hypoxic microenvironment to maximize the therapeutic efficacy of immune checkpoint blockade therapy (ICB), Yuan and coworkers designed cancer cell membrane-camouflaged gelatin NPs (CSG@B16F10) to deliver the O 2 -generating agent catalase and CD73siRNA simultaneously, thus enhancing tumor oxygenation by generating endogenous O 2 , and alleviating CD73-ADO pathway-mediated T cell immunosuppression for facilitating T-cell-specific immunity. 244 In addition, the fabricated biomimetic NPs can achieve immune evading and homologous targeting by retaining cancer cell membrane protein. This nanosystem successfully treated hypoxia and silenced CD73 in a synergistic way, which holds promise for improving the clinical immunological potency of PD-1/PD-L1 immune checkpoint inhibition.…”

Section: Hypoxia-relieving Strategies Based On Nanomedicinementioning

confidence: 99%

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Pan,

Liu,

Mou

et al. 2023

ACS Nano

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Cancer with a complex pathological process is a major disease to human welfare. Due to the imbalance between oxygen (O 2 ) supply and consumption, hypoxia is a natural characteristic of most solid tumors and an important obstacle for cancer therapy, which is closely related to tumor proliferation, metastasis, and invasion. Various strategies to exploit the feature of tumor hypoxia have been developed in the past decade, which can be used to alleviate tumor hypoxia, or utilize the hypoxia for targeted delivery and diagnostic imaging. The strategies to alleviate tumor hypoxia include delivering O 2 , in situ O 2 generation, reprogramming the tumor vascular system, decreasing O 2 consumption, and inhibiting HIF-1 related pathways. On the other side, hypoxia can also be utilized for hypoxia-responsive chemical construction and hypoxia-active prodrug-based strategies. Taking advantage of hypoxia in the tumor region, a number of methods have been applied to identify and keep track of changes in tumor hypoxia. Herein, we thoroughly review the recent progress of nanomedicine strategies in both conquering and utilizing hypoxia to combat cancer and put forward the prospect of emerging nanomaterials for future clinical transformation, which hopes to provide perspectives in nanomaterials design.

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“…The transition from non-immunogenic cell death to immunogenic cell death in cancer cells accelerated the release of DAMPs and further facilitated the activation of DCs in the tumor microenvironment (Scheme 1B). The maturation of DCs enhances the phagocytosis and presentation of tumor-related antigens, promotes the activation and differentiation of effector T cells, improves the efficacy of tumor immunity, [38][39][40][41] and achieves efficient killing and removal of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Cell membrane-specific self-assembly of peptide nanomedicine induces tumor immunogenic death to enhance cancer therapy

et al. 2023

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Reshaping hypoxia and silencing CD73 via biomimetic gelatin nanotherapeutics to boost immunotherapy

Cited by 15 publications

References 50 publications

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Cell membrane-specific self-assembly of peptide nanomedicine induces tumor immunogenic death to enhance cancer therapy

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