Resection of Solitary Metastasis

Solitary Metastases Presentation from Uveal Melanoma: Report of 3 Cases and a Comprehensive Review of the Literature

“…Research into the molecular and cellular biology and genetics of UM will shed a new light on the pathogenesis of its sitespecific metastasis and allow design more effective systemic therapies. In the few cases reported in the literature of solitary metastasis from UM, complete surgical resection was the primary treatment of the isolated metastasis, either in the liver [25,26,38] or in other locations [39][40][41]. This explains why when patients are eligible, surgical resection becomes the first treatment option, alone or in combination with regional therapies or systemic chemotherapy [42,43].…”

Solitary Metastases Presentation from Uveal Melanoma: Report of 3 Cases and a Comprehensive Review of the Literature

“…Research into the molecular and cellular biology and genetics of UM will shed a new light on the pathogenesis of its sitespecific metastasis and allow design more effective systemic therapies. In the few cases reported in the literature of solitary metastasis from UM, complete surgical resection was the primary treatment of the isolated metastasis, either in the liver [25,26,38] or in other locations [39][40][41]. This explains why when patients are eligible, surgical resection becomes the first treatment option, alone or in combination with regional therapies or systemic chemotherapy [42,43].…”

Metastatic uveal melanoma: The final frontier

“…Retrospective cohort studies on metastatic uveal melanoma predominate and mostly lack patient-level prognostic factors and treatment data, especially when not treated after first-line (Augsburger et al, 2008). Early on, patients who underwent surgery for metastases were suggested to have a longer overall survival (OS; for the purpose of this review, the time from either the date of diagnosis or the start of treatment for metastatic uveal melanoma to death or last follow-up) (Fournier et al, 1984;Gunduz et al, 1998), but these patients had in common early detection of relatively few metastases (Gomez et al, 2014). Immuno-oncological treatments, i.e.…”

Solitary Metastases Presentation from Uveal Melanoma: Report of 3 Cases and a Comprehensive Review of the Literature

“…Research into the molecular and cellular biology and genetics of UM will shed a new light on the pathogenesis of its sitespecific metastasis and allow design more effective systemic therapies. In the few cases reported in the literature of solitary metastasis from UM, complete surgical resection was the primary treatment of the isolated metastasis, either in the liver [25,26,38] or in other locations [39][40][41]. This explains why when patients are eligible, surgical resection becomes the first treatment option, alone or in combination with regional therapies or systemic chemotherapy [42,43].…”

Metastatic uveal melanoma: The final frontier

“…Retrospective cohort studies on metastatic uveal melanoma predominate and mostly lack patient-level prognostic factors and treatment data, especially when not treated after first-line (Augsburger et al, 2008). Early on, patients who underwent surgery for metastases were suggested to have a longer overall survival (OS; for the purpose of this review, the time from either the date of diagnosis or the start of treatment for metastatic uveal melanoma to death or last follow-up) (Fournier et al, 1984;Gunduz et al, 1998), but these patients had in common early detection of relatively few metastases (Gomez et al, 2014). Immuno-oncological treatments, i.e.…”

Solitary Metastases Presentation from Uveal Melanoma: Report of 3 Cases and a Comprehensive Review of the Literature

“…Research into the molecular and cellular biology and genetics of UM will shed a new light on the pathogenesis of its sitespecific metastasis and allow design more effective systemic therapies. In the few cases reported in the literature of solitary metastasis from UM, complete surgical resection was the primary treatment of the isolated metastasis, either in the liver [25,26,38] or in other locations [39][40][41]. This explains why when patients are eligible, surgical resection becomes the first treatment option, alone or in combination with regional therapies or systemic chemotherapy [42,43].…”

Metastatic uveal melanoma: The final frontier

“…Retrospective cohort studies on metastatic uveal melanoma predominate and mostly lack patient-level prognostic factors and treatment data, especially when not treated after first-line (Augsburger et al, 2008). Early on, patients who underwent surgery for metastases were suggested to have a longer overall survival (OS; for the purpose of this review, the time from either the date of diagnosis or the start of treatment for metastatic uveal melanoma to death or last follow-up) (Fournier et al, 1984;Gunduz et al, 1998), but these patients had in common early detection of relatively few metastases (Gomez et al, 2014). Immuno-oncological treatments, i.e.…”