Research update: Report from a workshop on cell biology of retinal detachment

Chloride Intracellular Channel 4 Is Critical for the Epithelial Morphogenesis of RPE Cells and Retinal Attachment

“…Most interestingly, many of these phenotypes were similar to those seen in an acutely induced RD animal model (Steinberg, 1986; Fisher et al , 2005). For example, the photoreceptor OS underneath CLIC4-sh/HcRed-targeted RPE cells were often overgrown and bent (Figure 5D).…”

Chloride Intracellular Channel 4 Is Critical for the Epithelial Morphogenesis of RPE Cells and Retinal Attachment

“…Most interestingly, many of these phenotypes were similar to those seen in an acutely induced RD animal model (Steinberg, 1986; Fisher et al , 2005). For example, the photoreceptor OS underneath CLIC4-sh/HcRed-targeted RPE cells were often overgrown and bent (Figure 5D).…”

Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina

“…Distal portions of the OS are embedded within pigment epithelial (PE) processes. The granulose texture there may originate from melanin and lipofuscin granules, phagosomes and residual bodies [38], expected to significantly decrease the recorded OCT signal as well as from longer rod outer segments. Figures 3 (c,f) show a section closer to the foveal center (1°eccentricity).…”

RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment

“…Whether the amount of disjunction results in reduced vision is presently unknown. However, visual field defects seen within the early days after detachment may be due not only to the separation of the photoreceptors from the RPE and thus reduced visual pigment regeneration and metabolic support for photoreceptors, 48 , 49 but also to reduced synaptic function.…”

Chloride Intracellular Channel 4 Is Critical for the Epithelial Morphogenesis of RPE Cells and Retinal Attachment

“…Most interestingly, many of these phenotypes were similar to those seen in an acutely induced RD animal model (Steinberg, 1986; Fisher et al , 2005). For example, the photoreceptor OS underneath CLIC4-sh/HcRed-targeted RPE cells were often overgrown and bent (Figure 5D).…”

Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina

“…Distal portions of the OS are embedded within pigment epithelial (PE) processes. The granulose texture there may originate from melanin and lipofuscin granules, phagosomes and residual bodies [38], expected to significantly decrease the recorded OCT signal as well as from longer rod outer segments. Figures 3 (c,f) show a section closer to the foveal center (1°eccentricity).…”

RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment

“…Whether the amount of disjunction results in reduced vision is presently unknown. However, visual field defects seen within the early days after detachment may be due not only to the separation of the photoreceptors from the RPE and thus reduced visual pigment regeneration and metabolic support for photoreceptors, 48 , 49 but also to reduced synaptic function.…”

Chloride Intracellular Channel 4 Is Critical for the Epithelial Morphogenesis of RPE Cells and Retinal Attachment

“…Most interestingly, many of these phenotypes were similar to those seen in an acutely induced RD animal model (Steinberg, 1986; Fisher et al , 2005). For example, the photoreceptor OS underneath CLIC4-sh/HcRed-targeted RPE cells were often overgrown and bent (Figure 5D).…”

Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina

“…Distal portions of the OS are embedded within pigment epithelial (PE) processes. The granulose texture there may originate from melanin and lipofuscin granules, phagosomes and residual bodies [38], expected to significantly decrease the recorded OCT signal as well as from longer rod outer segments. Figures 3 (c,f) show a section closer to the foveal center (1°eccentricity).…”

RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment

“…Whether the amount of disjunction results in reduced vision is presently unknown. However, visual field defects seen within the early days after detachment may be due not only to the separation of the photoreceptors from the RPE and thus reduced visual pigment regeneration and metabolic support for photoreceptors, 48 , 49 but also to reduced synaptic function.…”