Research status and perspectives for pathogenic spirochete vaccines

Duan, Junxia; Zhao, Yue; Zhang, Xiao­hong; Jiang, Hua; Xie, Bibo; Zhao, Tiantian; Zhao, Feijun

doi:10.1016/j.cca.2020.04.002

Cited by 4 publications

(2 citation statements)

References 80 publications

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“…Interestingly, in the LEfSe analysis of OP patients’ ocular prosthesis materials and use time, we found that the abundance of Alcaligenes , Dermabacter , and Spirochaetes in OP patients using glass as ocular prosthesis materials was higher than that in OP patients using PMMA. Current studies have shown that Alcaligenes is a conditional pathogen, which can cause blood flow, urinary tract, skin, soft tissue and middle ear infections ( Huang, 2020 ; Spencer et al., 2020 ); Dermabacter has a high correlation with many diseases and has been reported to cause bacteremia in patients ( Gómez-Garcés et al., 2001 ; Schaub et al., 2020 ); The colonization of Spirochaetes can cause uveitis, ocular syphilis and ocular leptospirosis ( Rathinam, 2002 ; Chao et al., 2006 ; Duan et al., 2020 ). The ocular flora of OP patients using PMMA has a high abundance of Aquabacterium and Devosia .…”

Section: Discussionmentioning

confidence: 99%

Conjunctival sac microbiome in anophthalmic patients: Flora diversity and the impact of ocular prosthesis materials

Zhao

Chen

Zheng

et al. 2023

Front. Cell. Infect. Microbiol.

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PurposeTo explore the changes of bacterial flora in anophthalmic patients wearing ocular prosthesis (OP) and the microbiome diversity in conditions of different OP materials.MethodsA cross-sectional clinical study was conducted, involving 19 OP patients and 23 healthy subjects. Samples were collected from the upper, lower palpebral, caruncle, and fornix conjunctiva. 16S rRNA sequencing was applied to identify the bacterial flora in the samples. The eye comfort of each OP patient was determined by a questionnaire. In addition, demographics information of each participant was also collected.ResultsThe diversity and richness of ocular flora in OP patients were significantly higher than that in healthy subjects. The results of flora species analysis also indicated that in OP patients, pathogenic microorganisms such as Escherichia Shigella and Fusobacterium increased significantly, while the resident flora of Lactobacillus and Lactococcus decreased significantly. Within the self-comparison of OP patients, compared with Polymethyl Methacrylate (PMMA), prosthetic material of glass will lead to the increased colonization of opportunistic pathogens such as Alcaligenes, Dermabacter and Spirochaetes, while gender and age have no significant impact on ocular flora.ConclusionsThe ocular flora of OP patients was significantly different from that of healthy people. Abundant colonization of pathogenic microorganisms may have an important potential relationship with eye discomfort and eye diseases of OP patients. PMMA, as an artificial eye material, demonstrated potential advantages in reducing the colonization of opportunistic pathogens.

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Section: Discussionmentioning

confidence: 99%

Conjunctival sac microbiome in anophthalmic patients: Flora diversity and the impact of ocular prosthesis materials

Zhao

Chen

Zheng

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Several syphilis candidates have been investigated over the past few years, including whole-cell inactivated, live attenuated or genetically engineered vaccines [80].…”

Section: Syphilis Prevention and Vaccinesmentioning

confidence: 99%

A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines

et al. 2021

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In 2021 the scientific community's efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum (TP) and is one of the oldest known diseases. Its incidence has increased in the last few years and syphilis still remains a contemporary plague that continues to afflict millions of people worldwide. Despite research improvements, syphilis pathogenesis is not completely clear; clinical presentation is very heterogeneous and the diagnosis can sometimes be difficult. Furthermore, few therapeutic options are available, and a vaccine has not been found yet. In this review, we describe the most recent evidence concerning the clinical manifestation, diagnosis, treatment and vaccine prospectives for this disease.

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