Research Progress on the Role of Inflammatory Mechanisms in the Development of Postoperative Cognitive Dysfunction

Tan, Xiaoxiang; Qiu, Lili; Sun, Jiangzhou

doi:10.1155/2021/3883204

Cited by 40 publications

(27 citation statements)

References 156 publications

(153 reference statements)

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“…Briefly speaking, there are probably a couple of reasons for studying inflammation: on the one hand, inflammation can be regarded as a bridge connecting the cardiac surgery and neurocognitive disorders. Through upregulating cyclooxygenase 2 isozyme (COX-2) and matrix metalloproteinases (MMPs), peripheral pro-inflammatory cytokines can disrupt the integrity of the blood-brain barrier (BBB), allowing bone-marrow-derived monocytes (BMDM) to activate microglia cells and trigger neuroinflammation (Tan et al, 2021 ). Besides, Thackeray et al ( 2018 ) reported that biphasic peaks of neuroinflammation in early acute and late chronic stages of cardiac injury were similar to a biphasic microglial activation pattern with peaks at initial onset of mild cognitive impairment and late advanced Alzheimer's disease.…”

Section: Resultsmentioning

confidence: 99%

Potential Markers of Neurocognitive Disorders After Cardiac Surgery: A Bibliometric and Visual Analysis

2022

Front. Aging Neurosci.

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BackgroundIdentifying useful markers is essential for diagnosis and prevention of perioperative neurocognitive disorders (PNDs). Here, we attempt to understand the research basis and status, potential hotspots and trends of predictive markers associated with PNDs after cardiac surgery via bibliometric analysis.MethodsA total of 4,609 original research articles and reviews that cited 290 articles between 2001 and 2021 were obtained from the Web of Science Core Collection (WoSCC) as the data source. We used the software CiteSpace to generate and analyze visual networks of bibliographic information, including published years and journals, collaborating institutions, co-cited references, and co-occurring keywords.ResultsThe number of annual and cumulative publications from 2001 to 2021 has been increasing on the whole. The Harvard Medical School was a very prolific and important institution in this field. The journal of Ann Thorac Surg (IF 4.33) had the most publications, while New Engl J Med was the most cited journal. Neuron-specific enolase (NSE), S100b and kynurenic acid (KYNA) were frequently discussed as possible markers of PNDs in many references. Cardiopulmonary bypass (CPB) was a keyword with high frequency (430) and sigma (6.26), and inflammation was the most recent burst keyword.ConclusionPotential markers of PNDs has received growing attention across various disciplines for many years. The research basis mainly focuses on three classic biomarkers of S100b, NSE, and KYNA. The most active frontiers are the inflammation-related biomarkers (e.g., inflammatory cells, cytokines, or mediators) and surgery-related monitoring parameters (e.g., perfusion, oxygen saturation, and the depth of anesthesia).

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Section: Resultsmentioning

confidence: 99%

Potential Markers of Neurocognitive Disorders After Cardiac Surgery: A Bibliometric and Visual Analysis

2022

Front. Aging Neurosci.

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“…Presently, there are several hypotheses about the pathogenesis of POCD, which are related to inflammation of the central nervous system, nerve cell apoptosis, dysfunction of the cholinergic nervous system, and oxidative stress injury. However, inflammation of the nervous system still plays an important role in the development of POCD [ 16 , 32 , 33 ]. According to our previous study, microRNA-221-3p could target IRF2 of astrocytes to increase IFN-α expression and regulate nervous system inflammation [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma microRNA-221-3p as a biomarker for POCD after non-cardiac surgery

et al. 2022

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Our previous study showed that the plasma microRNA-221-3p level could serve as a biomarker for major depression or mood. This study aimed to further investigate the role of plasma microRNA-221-3p level in postoperative cognitive dysfunction (POCD). Patients undergoing non-cardiac surgery were randomly assigned according to the inclusion and exclusion criteria. POCD was diagnosed by the Z score method. The relative level of plasma microRNA-221-3p was decided by quantitative real-time polymerase chain reaction. Multiple logistic regression analysis and receiver operating characteristic(ROC) curves were used for the analysis of plasma microRNA-221-3p prediction performance for POCD. At 7 days post-surgery, the rate of POCD was 34.04%. Patients in the POCD group had a higher preoperative depression score, older age, and longer operation duration than that in the NPOCD group. The relative level of plasma microRNA-221-3p in the POCD group was 1.78 and 2.73 times higher than that in the NPOCD group at 1 day before and 7 days after the surgery, respectively. The relative content of plasma microRNA-221-3p at 7 days after operation was an independent risk factor for POCD. The ROC curves showed that the area under the curve was 0.938 for plasma microRNA-221-3p at postoperative 7 days, and the threshold for POCD detection was 12.33 with a sensitivity and specificity of 81.3% and 96.3%, respectively. Our results indicate that the plasma postoperative microRNA-221-3p levels could be an effective predictor for POCD after non-cardiac surgery.

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“…In the study, it is found that neuroinflammation can promote the release of peripheral inflammation-related factors (IL-1β, IL-6, TNF-α, IL-17, etc. ), destroy the protective effect of the blood-brain barrier on the center, induce central inflammation, and lead to neuronal apoptosis and synaptic loss [16]. In mice, surgery and anesthesia increased the expression of the high mobility group box-1 (HMGB1) in the cerebral cortex and hippocampus [17].…”

Section: Pocd and Inflammatory Reactions Of The Central Nervous Syste...mentioning

confidence: 99%

Research Progress on the Effect of IL-17 on Postoperative Cognitive Dysfunction

2022

JCMP

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Postoperative cognitive dysfunction (POCD), which is used to describe the decline of learning and memory after the operation, has been known for decades, but this issue has been controversial because of the differences in age, education level and assessment tools. With the aging of the population and the increase in the amount of anesthetic surgery, the incidence of POCD also increases. At present, the cause of the above phenomenon is not clear. Recent studies have found that inhibition of the inflammatory CD4 + T-cell lineage and T helper 17 (Th17) cells can greatly improve POCD. It is worth noting that IL-17 is a new type of inflammatory cytokine secreted by Th17 cells, which may play a role in the development of POCD. Therefore, based on the above analysis, this article reviews the role and clinical value of IL-17 in POCD.

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Research Progress on the Role of Inflammatory Mechanisms in the Development of Postoperative Cognitive Dysfunction

Cited by 40 publications

References 156 publications

Potential Markers of Neurocognitive Disorders After Cardiac Surgery: A Bibliometric and Visual Analysis

Potential Markers of Neurocognitive Disorders After Cardiac Surgery: A Bibliometric and Visual Analysis

Plasma microRNA-221-3p as a biomarker for POCD after non-cardiac surgery

Research Progress on the Effect of IL-17 on Postoperative Cognitive Dysfunction

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