Research progress on gels-based nanocomposites in the diagnostics and therapy of prostate diseases

Zhong, Rongfang; Chu, Ruixi; Zhu, Jing; Ling, Jiacheng; Zhang, Li; Zhou, Yong; Yin, Minmin; Hao, Zongyao; Liang, Chaozhao; Cao, Sufeng; Xu, Tao; Ye, Sheng; Fan, ST

doi:10.1016/j.mtsust.2023.100323

Cited by 3 publications

(4 citation statements)

References 151 publications

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“…The clinical application of nanotechnology is mainly reflected in diagnosis and treatment. 55,56 In the following section, we summarize the targeted NPs acting on thrombi, the BBB, and ischaemic brain tissue during the development of IS to achieve early detection and diagnosis of thrombus. At the same time, the effective therapeutic components of the drug cross the BBB and reach the lesion site of IS to exert a therapeutic effect.…”

Section: Strategies Of Targeted Nps In the Treatment Of Ismentioning

confidence: 99%

Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

Li,

Wang,

Fang

et al. 2023

Mater. Adv.

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Section: Strategies Of Targeted Nps In the Treatment Of Ismentioning

confidence: 99%

Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

Li,

Wang,

Fang

et al. 2023

Mater. Adv.

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“…28,29 In contrast, in Type II PDT, the photosensitizer absorbs light energy and converts its excited triplet state oxygen (O 2 ) into excited monomorphic oxygen ( 1 O 2 ) through energy transfer. 1 O 2 is a highly oxidizing ROS that can cause oxidative damage directly or indirectly. 30 In summary, Type II PDT is the main ROS-producing modality in PDT, with 1 O 2 as its main product.…”

Section: Ros-based Generation Of Pdt Typesmentioning

confidence: 99%

“…Prostate cancer (PCa) is the second most common cancer in males . While localized and regional prostate cancer has a near 100% 5-year survival rate, advanced tumors have a significantly lower survival rate. , According to the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO), there will be approximately 1.41 million new cases of prostate cancer and approximately 380,000 deaths worldwide by 2020 .…”

Section: Introductionmentioning

confidence: 99%

Versatile Design of Organic Polymeric Nanoparticles for Photodynamic Therapy of Prostate Cancer

Ling,

Gu,

Liu

et al. 2023

ACS Mater. Au

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Radical prostatectomy is a primary treatment option for localized prostate cancer (PCa), although high rates of recurrence are commonly observed postsurgery. Photodynamic therapy (PDT) has demonstrated efficacy in treating nonmetastatic localized PCa with a low incidence of adverse events. However, its limited efficacy remains a concern. To address these issues, various organic polymeric nanoparticles (OPNPs) loaded with photosensitizers (PSs) that target prostate cancer have been developed. However, further optimization of the OPNP design is necessary to maximize the effectiveness of PDT and improve its clinical applicability. This Review provides an overview of the design, preparation, methodology, and oncological aspects of OPNP-based PDT for the treatment of PCa.

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“…Consequently, prostatitis is often challenging to treat fully. Over the years, various synthetic chemical molecules (such as ciprofloxacin (CIP), norfloxacin, flomoxef, and cilastatin) ( Dan et al, 1987 ; Schaeffer and Darras, 1990 ; Kuiper et al, 2020 ; Nakamura et al, 2020 ; Zheng J. et al, 2022 ) and herbal medicines have been developed into oral dosage forms ( Hu et al, 2022 ; Xu et al, 2022 ; Gao et al, 2023 ; Zhong et al, 2023 ). In clinics, doctors often combine traditional Chinese medicines with Western medicine and antibiotics for improved therapeutic effects on patients with chronic bacterial prostatitis.…”

Section: Introductionmentioning

confidence: 99%

A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Sun,

Zhou,

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Bacterial prostatitis is a challenging condition to treat with traditional dosage forms. Physicians often prescribe a variety of dosage forms with different administration methods, which fail to provide an efficient and convenient mode of drug delivery. The aim of this work was to develop a new type of hybrid material incorporating both electrosprayed core-shell microparticles and electrospun nanofibers. A traditional Chinese medicine (Ningmitai, NMT) and a Western medicine (ciprofloxacin, CIP) were co-encapsulated within this material and were designed to be released in a separately controlled manner. Utilizing polyvinylpyrrolidone (PVP) as a hydrophilic filament-forming polymer and pH-sensitive Eudragit® S100 (ES100) as the particulate polymeric matrix, a combined electrohydrodynamic atomization (EHDA) method comprising coaxial electrospraying and blending electrospinning, was used to create the hybrids in a single-step and straightforward manner. A series of characterization methods were conducted to analyze both the working process and its final products. Scanning electron microscopy and transmission electron microscopy revealed that the EHDA hybrids comprised of both CIP-PVP nanofibers and NMT-ES100 core-shell microparticles. Multiple methods confirmed the rapid release of CIP and the sustained release of NMT. The antibacterial experiments indicated that the hybrids exhibited a more potent antibacterial effect against Escherichia coli dh5α and Bacillus subtilis Wb800 than either the separate nanofibers or microparticles. The amalgamation of fibrous nanomedicine and particulate micromedicine can expand the horizon of new types of medicines. The integration of electrospinning and coaxial electrospraying provides a straightforward approach to fabrication. By combining hydrophilic soluble polymers and pH-sensitive polymers in the hybrids, we can ensure the separate sequential controlled release of CIP and NMT for a potential synergistic and convenient therapy for bacterial prostatitis.

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Research progress on gels-based nanocomposites in the diagnostics and therapy of prostate diseases

Cited by 3 publications

References 151 publications

Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

Versatile Design of Organic Polymeric Nanoparticles for Photodynamic Therapy of Prostate Cancer

A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

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