Under the background of global economic digitalization, retail trade, as a new industry, has shown a trend of gradual scale, standardization and sustainable development, and has become an important supporting force for regional economic development. As a developing country, the Philippines' retail trade has gradually shown a rapid development trend, with an annual growth rate of over 20%. Taking the largest e-commerce company in the Philippines as the research object, this study quantitatively analyzes the development of retail trade in the Philippines from the aspects of total transaction volume, B2B market and B2C market, and finds that the practice of the coordinated development mechanism of E-commerce industry cluster and regional economy has been successful, which further has a significant positive impact on the overall economic and social development of the Philippines.