Research Article Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes.

Abstract

ABSTRACT. Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose transporter and has been associated with various diseases, including diabetes mellitus. We investigated the association of the polymorphisms rs187238 (IL-18) and rs5435 (GLUT4) in a case-control study in Euro-Brazilians with T1D (N = 136) and healthy subjects (N = 144). Real-time PCR with TaqMan ® fluorescent probes were applied for genotyping. All polymorphisms were in Hardy-Weinberg equilibrium. The minor allele frequencies for the G-allele (rs187238; IL-18) in healthy and T1D groups were 28.5% [95%CI = 23-34%] vs 31.6% [95%CI = 26-37%], P = 0.416, and for the T-allele (rs5435, GLUT4) were 33% Genotype comparisons for both polymorphisms showed no significant differences (P > 0.05). The polymorphisms rs187238 and rs5435 were not associated with T1D in the studied population. The minor allele frequencies for both polymorphisms were similar to those of other Caucasian populations.

Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review

“…With reference to IL-17, increased serum IL-17A is a risk factor for autoimmune T1DM [14]. Finally, IL-18 has a controversial role because the IL-18 gene promoter polymorphisms might be associated with susceptibility to T1DM in Egyptian children [16] and with T1DM age onset [27], but at the same time according to Campos L. P. et al [24] IL-18 polymorphisms were not associated with T1DM onset in children or adults in this population, along with Al-Lahham Y. et al [32], according to which IL-18 rs187238 was not associated with T1DM in Euro-Brazilian population.…”

Exploring Interleukin Levels in Type 1 Diabetes and Periodontitis: A Review with a Focus on Childhood

“…Patients with T1DM+CP had higher circulating IL-8 levels than healthy controls+P/non-P. Seyfarth J. et al, 2018 [32] Only T1DM children with the protective haplotype had lower IL-7 serum levels. Al-Lahham Y. et al, 2017 [33] IL-18 rs187238 was not associated with T1DM in a Euro-Brazilian population.…”

“…Finally, IL-18 has a controversial role because the IL-18 gene-promoter polymorphisms might be associated with susceptibility to T1DM in Egyptian children [18] and with T1DM age onset [29]; however, at the same time, according to Campos L. P. et al [26], IL-18 polymorphisms were not associated with T1DM onset in children or adults in this population. In addition, Al-Lahham Y. et al [33] also found that IL-18 rs187238 was not associated with T1DM in a Euro-Brazilian population.…”

Клінічна ефективність аеробних фізичних навантажень у молодих пацієнтів iз цукровим діабетом 1-го типу

“…Thus, physical activity in patients with type 1 DM may affect glycemia during some hours. The decrease in glycemia is related to the divergence between production and utilization of glucose [3,9]. This one affects the suppressing level of insulin.…”