Research Article: Determination of median lethal concentration (LC50) and histopathological effects of malachite green on Oncorhynchus mykiss

Heydari, Mohaddeseh; Yaghoobi, Z; Hosseini, S; Mahdavi, J; Movahedinia, Abdolali; Amini, Z; Rouzbehani, S

doi:10.52547/ijaah.8.1.41

Cited by 2 publications

(1 citation statement)

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“…However, the monitoring studies clearly show us illegal usage of it (Liang et In vivo researches on its metabolism in sh is limited. LC50 values were reported as 0.83 mg/L for 96 hours in rainbow trout and 1.06 mg/L for 96 hours in tilapia (Heydari et al 2022;Kwan et al 2019). In a study, malachite green concentration has been determined as 0.0057-0.384 µg/L in sh farm e uent (Amin and Khodabakhshi 2012).…”

Section: Discussionmentioning

confidence: 99%

In Vivo Modulatory Effect of Malachite Green on Cytochrome P450 and Antioxidant Enzyme Activities in Rainbow Trout Liver

Bozcaarmutlu-Büken,

Yıldırım,

Sapmaz

et al. 2024

Preprint

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Malachite green is a mutagenic and carcinogenic chemical used in textile and paper industry as a dye and fish farms against ectoparasites as well as bacteria and fungal infections. Aquatic organisms are under the risk of malachite green exposure. In this study, our aim was to determine the effect of two different doses of malachite green on cytochrome P450 system and antioxidant system in rainbow trout (Oncorhynchus mykiss). For this purpose, 24 fish were randomly divided into three groups namely control, 0.1 mg/L malachite green treatment group and 0.5 mg/L malachite green treatment group. Highly elevated 7-ethoxyresorufin-O-deethylase activities (EROD) were measured in fish treated with 0.5 mg/L malachite green. 7-pentoxyresorufin O-depentylase (PROD) activities increased with increasing doses of malachite green. Catalase (CAT) and glutathione reductase (GR) activities of 0.1 mg/L malachite green administration group were higher than that of the control group. Erythromycin N-demethylase (ERND) activities were higher in treatment groups than that of the control group. However, these differences in ERND activities were not statistically significant. Glutathione S-transferase (GST) activities were not affected from the malachite green treatment in both of the treatment groups. In this study, it is clear that malachite green has modulatory effect on EROD, PROD, CAT and GR activities in rainbow trout.

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Section: Discussionmentioning

confidence: 99%