Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors

Zhao, Haiyang; Wu, Jiang; Zhu, Jingjing; Xiao, Zecong; He, Chaochao; Shi, Hongxue; Li, Xiaokun; Yang, Shulin; Xiao, Jian

doi:10.1155/2015/808202

Cited by 42 publications

(35 citation statements)

References 59 publications

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“…Combination of the GFs with suitable biomaterial allows for preservation of GFs activity and enables their sustained release. Among the many known growth factors, bone morphogenetic proteins (BMPs), insulin-like growth factor-1 (IGF-1), transforming growth factor-β (TGF-β), basic fibroblast growth factor-2 (FGF-2), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) are most commonly used for TE applications [19,25,32,36,72,73,84,85,[91][92][93]. This review focuses on three of them, i.e., BMPs, FGF-2, and VEGF.…”

Section: Growth Factorsmentioning

confidence: 99%

“…Basic fibroblast growth factor-2 (FGF-2) is produced by fibroblasts and endothelial cells [86]. It primarily simulates cell proliferation and differentiation [73,91]. Moreover, FGF-2 affects angiogenesis, adipogenesis, wound healing, and tissue repair [95].…”

Section: Fibroblast Growth Factor-2 (Fgf-2)mentioning

confidence: 99%

“…It also improves epidermal repair and formation of granulation tissue. VEGF is known to promote bone repair, while its absence leads to inhibition of bone regeneration [16,88,91,99,101].…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Section: Growth Factorsmentioning

confidence: 99%

Section: Fibroblast Growth Factor-2 (Fgf-2)mentioning

confidence: 99%

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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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“…Various techniques are involved in the fabrication of scaffolds, such as lyophilizing, phase separating, foaming, rapid prototyping, and electrospinning, among others. However, the electrospinning technique has advantages compared with other techniques, because it is easy to perform, versatile, and allows better control of pore fabrication [28][29][30][31][32][33].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Tissue engineering perspectives in dentistry: review of the literature

Moro

Barcelos

Terra

et al. 2018

RGO, Rev. Gaúch. Odontol.

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Tooth losses due to pathological processes continue to be a reality in daily clinical dentistry, inducing functional and psychological complications in patients. In view of this, a new option for the management of this problem -tissue engineering -has been studied in Dentistry. This field, considered multidisciplinary, uses three key elements for tissue regeneration: scaffolds (extracellular matrices) -natural or synthetic; cells, and growth factors. In this sense, combination of these three elements may induce regeneration of the dental pulp, bone and periodontal tissue, among others. Therefore, the aim of this study was to conduct a literature review, describing the main elements of tissue engineering and their applicability in Dentistry, as a means of updating dental surgeons about this subject.Indexing terms: Tissue engineering. Dentistry. Cell-and tissue-based therapy. RESUMOAs perdas dentárias, devido aos processos patológicos, ainda são uma realidade na clínica odontológica diária, induzindo complicações funcionais e psicológicas ao paciente. Diante disso, uma nova opção para o manejo desse problema vem sendo estudada na Odontologia, a engenharia tecidual. Essa área, considerada multidisciplinar, utiliza três elementos chaves para a regeneração dos tecidos: os scaffolds (matriz extracelular) naturais ou sintéticos, as células e os fatores de crescimento. Nesse sentido, a combinação desses três elementos pode induzir a regeneração da polpa dentária, tecido ósseo e periodontal, entre outros. Portanto, o objetivo deste estudo é realizar uma revisão da literatura, descrevendo e atualizando os cirurgiões-dentistas sobre os principais elementos da engenharia tecidual e sua aplicabilidade na Odontologia. Termos de indexação: Engenharia tissular. Odontologia. Terapia baseada em transplante de células e tecidos.

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“…These problems may be addressed by retaining lactoferrin by its immobilization onto the GBR membrane by chemical conjugation or ionic interaction. 24 In this study, we hypothesized that the stable immobilization of lactoferrin onto GBR nanofibers could increase bone regeneration and decrease inflammatory reactions. Given that, we developed electrospun synthetic nanofibers immobilized with lactoferrin through adhesive polydopamine coating method.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Membrane Immobilized with Lactoferrin for Modulation of Bone Regeneration and Inflammation

Lee

et al. 2020

Tissue Engineering Part A

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Guided bone regeneration refers to the process in which bone defects could be regenerated by facilitated healing through the use of membranes, potentially with the delivery of osteoinductive molecules, however, the regeneration often failed due to inflammation during bone formation. In this study, we developed a membrane immobilized with lactoferrin to modulate both bone regeneration and inflammatory responses. Lactoferrin was immobilized on electrospun nanofibers (LF50) by exploiting an adhesive polydopamine coating method. When human adipose-derived stem cells (hADSCs) were seeded onto the nanofibers, the LF50 significantly increased the osteogenic differentiation. For example, the gene expression of osteopontin was 6.9 -2.3 times greater in the cells on LF50 than the cells on unmodified nanofibers without lactoferrin. In addition, the gene expression of tumor necrosis factor-alpha (TNF-a) of the macrophage cell line (RAW264.7) cultured on the LF50 was 0.3 -0.1 times reduced, indicating the lactoferrin was able to reduce inflammatory response. With implantation of nanofibers on in vivo mouse calvarial defects, the LF50 resulted in 60.9% -4.5% of new bone formation, which was six times greater than the results of other groups. Furthermore, when the fibers were implanted onto the in vivo mouse subcutaneous model challenged with lipopolysaccharide and interferon-g, the area of inflammatory tissue was significantly reduced in the LF50 implanted group as 0.6 -0.1 mm 2 as compared with the control group (1.1 -0.1 mm 2 ). Taken together, the lactoferrin immobilization onto the nanofiber by polydopamine chemistry may be an effective delivery method for improving bone regeneration while regulating the inflammation.In vivo critical-sized bone reconstruction remains challenging due to the severe inflammation, which would be an unavoidable problem during surgical process. Therefore, the present study aims to develop a guided nanofibrous membrane immobilized with lactoferrin, which has dual functions with osteoinduction and anti-inflammation. The lactoferrinimmobilized fibers demonstrated significantly enhanced in vitro osteogenic differentiation of adipose-derived stem cells as well as decreased polarization of macrophage to M1 with relatively reduced amount than that reported from previous reports. We also found that the membrane improved in vivo bone regeneration and decreased inflammatory tissue formation. Taken together, this system would be a new platform for successful bone regeneration.

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Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors

Cited by 42 publications

References 59 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Tissue engineering perspectives in dentistry: review of the literature

Bioactive Membrane Immobilized with Lactoferrin for Modulation of Bone Regeneration and Inflammation

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