Mol. Reprod. Dev.
 1999
DOI: 10.1002/(sici)1098-2795(199902)52:2<183::aid-mrd9>3.0.co;2-6
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Requirement of sperm-oocyte plasma membrane fusion for establishment of the plasma membrane block to polyspermy in human pronuclear oocytes

Kazuo Sengoku
1
,
Kenichi Tamate
2
,
Yasuo Takaoka
3
et al.
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Cited by 25 publications

(17 citation statements)
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“…Importantly, this pattern was not observed following ICSI, which accomplishes fertilization without sperm-egg membrane fusion. In similar fashion, the plasma membrane block to polyspermy does not occur following ICSI or parthenogenetic activation, but instead requires some additional signal induced by sperm-egg fusion for its establishment (32)(33)(34)(35)(36)(37). This result is also consistent with the recent observation that fertilization by sperm lacking PLCζ fails to initiate the typical robust pattern of Ca 2+ oscillations but prompts a small number of Ca 2+ transients that begin following a delay (6).…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Importantly, this pattern was not observed following ICSI, which accomplishes fertilization without sperm-egg membrane fusion. In similar fashion, the plasma membrane block to polyspermy does not occur following ICSI or parthenogenetic activation, but instead requires some additional signal induced by sperm-egg fusion for its establishment (32)(33)(34)(35)(36)(37). This result is also consistent with the recent observation that fertilization by sperm lacking PLCζ fails to initiate the typical robust pattern of Ca 2+ oscillations but prompts a small number of Ca 2+ transients that begin following a delay (6).…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Interestingly, when gamete recognition was circumvented by ICSI, Juno was not removed from the oocyte surface and the egg remained receptive to further sperm [78]. This finding is consistent with previous observations that ICSI does not induce an effective block to polyspermy in mammalian eggs [118,119]. Studies are being undertaken to provide the evidence that the removal of Juno from egg s surface contributes to the establishment of a polyspermy block in humans.…”
Section: Juno Removalsupporting
confidence: 85%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The polymer has multiple carboxyl groups that may chelate calcium and induce activation. Many parthenogenetic agents are calcium ionophores or compete with calcium, and these types of parthenogenetic reagents are not able to actuate the membrane block to polyspermy ,, , just as we observe with polymer 1 10 .…”
Section: Resultsmentioning
confidence: 71%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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