2015
DOI: 10.18632/aging.100743
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: The stem cell genomic stability forms the basis for robust tissue homeostasis, particularly in high-turnover tissues. For the genomic stability, DNA damage response (DDR) is essential. This study was focused on the role of two major DDR-related factors, ataxia telangiectasia-mutated (ATM) and ATM- and RAD3-related (ATR) kinases, in the maintenance of intestinal stem cells (ISCs) in the adult Drosophila midgut. We explored the role of ATM and ATR, utilizing immunostaining with an anti-pS/TQ antibody as an indic… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
8
0

Year Published

2016
2016
2018
2018

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 12 publications
(8 citation statements)
references
References 37 publications
(8 reference statements)
0
8
0
Order By: Relevance
“…Interestingly, ATM has been shown to be required for maintaining self-renewal of adult hematopoietic stem cells and germline stem cells in mice in the absence of DNA damage (Ito et al, 2004;Takubo et al, 2008), and ATR has also been shown to be required in multiple tissue stem cells in mice (Ruzankina et al, 2007). In Drosophila, both Mei-41 (ATR) and Tefu (ATM) are required to maintain intestinal stem cells in the absence of DNA damage (Park et al, 2015). However, it remains unclear whether CHK2 (Lok in Drosophila) is also implicated in maintaining selfrenewal of adult stem cells in the absence of DNA damage.…”
Section: Introductionmentioning
confidence: 99%
“…However, iron is also an essential element required for cellular metabolism. When iron is required for the growth of tumor cells, it may also initiate DNA oxidative damage to the tumor cells (34). Therefore, it can be inferred that DpC is able to inhibit the proliferation of HNSCC cells and induce apoptosis by regulating the DNA-damage-signaling pathway, which is closely associated with the occurrence and development of HNSCC.…”
Section: Discussionmentioning
confidence: 99%
“…Two DNA damage response-related signaling pathways, ataxia telangiectasia-mutated (ATM) and ATM- and RAD3-related (ATR) kinases, were responsible for ISC maintenance and proliferation. ATM and ATR activation were increased with age, and ATM and/or ATR loss in precursors reduced aging-induced ISC proliferative activity [ 80 ]. Importantly, identification of the molecular mechanisms that mediate symmetric ISC division in the aging intestine will provide a platform to improve certain aspects of specific aging-related diseases in humans.…”
Section: Reviewmentioning
confidence: 99%
“…Expression of DDR-related factors is associated with the modulation of aging and diseases including cancer [ 42 , 43 ]. Interestingly, the extent of DDR’s influence on the regulation of the stem cell number and their proliferation are currently unknown, however, DDR suppression leads to stem cell loss in insects and mammals [ 44 , 45 ]. In humans, patients heterozygous for DDR-related genes affecting DDR system have an increased risk of cancer development.…”
Section: Introductionmentioning
confidence: 99%
“…We suspected that the different phenotypes in stem cell proliferation induced by DDR deficiency might be associated with differences in the depletion in stem and niche cells. Although the depletion of stem cell-intrinsic DDR leads to decreased proliferation activity and loss of stem cells [ 45 ] and DDR increases in ECs undergoing age and oxidative stress [ 14 , 45 ], the role of niche-specific DDR in aging of tissues-resident stem cells has not been clearly demonstrated.…”
Section: Introductionmentioning
confidence: 99%