2020
DOI: 10.3390/molecules25092155
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Abstract: Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression is a significant type of mood disorder, where patients suffer from pathological disturbances associated with a proinflammatory M1 macrophage phenotype. Presently, the most commonly used antidepressants such as Zoloft and Citalopram can reduce inflammation, but suffer from dangerous side effects without offering specificity toward macrophages. We employed … Show more

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Cited by 9 publications
(16 citation statements)
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“…Captivating developments could include integrating more than one sequencing method to simultaneously measure several parameters (e.g., genome, transcriptome, methylome. It could also highlight the change of microglia population‐based on investigating microglia markers evolution and the effect of drugs 51,66,70 ). An interesting topic also is the detection of different isoforms and alternative splicing cases of microglial markers 71 .…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Captivating developments could include integrating more than one sequencing method to simultaneously measure several parameters (e.g., genome, transcriptome, methylome. It could also highlight the change of microglia population‐based on investigating microglia markers evolution and the effect of drugs 51,66,70 ). An interesting topic also is the detection of different isoforms and alternative splicing cases of microglial markers 71 .…”
Section: Resultsmentioning
confidence: 99%
“…13 LPS is a known endotoxin that induces an acute response in the body. 51 Thus it is safe to assume that there will be a shift of microglia transcriptomic profile into proinflammation in response to LPS injection. However, the exact phenotype of this population was not yet known.…”
Section: Lps Effect On Microgliamentioning
confidence: 99%
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“…The database was searched using our built-in AI search tool (AIST) [ 23 ]. The input to AIST was the question “What are the genes that affect endothelial migration?”, in addition to our database.…”
Section: Methodsmentioning
confidence: 99%
“…The study validated prediction for the lipoxygenase inhibitor drug zileuton as a modulator of the NRF2 pathway in vitro , with potential applications to reduce macrophage M1 phenotype and reactive oxygen species production. This novel approach has been proved to effective for reposition in NDDs [ 439 ]. With the rapid development of systems-based pharmacology and polypharmacology, method development for the rational design of multi-target drugs has to become urgent.…”
Section: Implementation Of Artificial Intelligence In De Novo Drug Dementioning
confidence: 99%