Reproductive safety evaluation of L-Ergothioneine

Forster, Roy; Spézia, François; Papineau, Dominique; Sabadie, Caroline; Erdelmeier, Irène; Moutet, Marc; Yadan, Jean‐Claude

doi:10.1016/j.fct.2015.02.019

Cited by 30 publications

(34 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been hypothesized that ergothioneine administration may prevent tissues against oxidative damage [71] and that decreased blood plasma levels of ergothioneine have been reported in elderly [72] and Parkinson's disease [73]. Studies in animals and humans have found no toxicity, and ergothioneine has been recently approved as a nutritional supplement [74,75].…”

Section: Ergothioneinementioning

confidence: 99%

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

2020

View full text Add to dashboard Cite

L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system. Several HIS-rich proteins (e.g., haemoproteins, HIS-rich glycoproteins, histatins, HIS-rich calcium-binding protein, and filaggrin), HIS-containing dipeptides (particularly carnosine), and methyl- and sulphur-containing derivatives of HIS (3-methylhistidine, 1-methylhistidine, and ergothioneine) have specific functions. The unique chemical properties and physiological functions are the basis of the theoretical rationale to suggest HIS supplementation in a wide range of conditions. Several decades of experience have confirmed the effectiveness of HIS as a component of solutions used for organ preservation and myocardial protection in cardiac surgery. Further studies are needed to elucidate the effects of HIS supplementation on neurological disorders, atopic dermatitis, metabolic syndrome, diabetes, uraemic anaemia, ulcers, inflammatory bowel diseases, malignancies, and muscle performance during strenuous exercise. Signs of toxicity, mutagenic activity, and allergic reactions or peptic ulcers have not been reported, although HIS is a histamine precursor. Of concern should be findings of hepatic enlargement and increases in ammonia and glutamine and of decrease in branched-chain amino acids (valine, leucine, and isoleucine) in blood plasma indicating that HIS supplementation is inappropriate in patients with liver disease.

show abstract

Section: Ergothioneinementioning

confidence: 99%

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

2020

View full text Add to dashboard Cite

show abstract

“…Interestingly, ERG is also present in seminal fluid (394)(395)(396) and human breast milk (6) . Any possible correlation with male fertility (397) seems not to have been established, though there were no negative effects (398) , and ERG improved oocyte quality and maturation in cows and sheep (399) . ERG is also present in eye lens, where its concentration is lower in individuals with cataracts (400) .…”

Section: Serum and Other Concentrationsmentioning

confidence: 99%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

View full text Add to dashboard Cite

Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but is not synthesised by plants and animals who acquire it via the soil and their diet, respectively. Animals have evolved a highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) in humans, signifying its importance, and ERG may even have the status of a vitamin. ERG accumulates differentially in various tissues, according to their expression of SLC22A4, favouring those such as erythrocytes that may be subject to oxidative stress. Mushroom or ERG consumption seems to provide significant prevention against oxidative stress in a large variety of systems. ERG seems to have strong cytoprotective status, and its concentration is lowered in a number of chronic inflammatory diseases. It has been passed as safe by regulatory agencies, and may have value as a nutraceutical and antioxidant more generally.

show abstract

“…Further, no obvious external gross morphological deformities were detected in pups treated both with extract and control. Forster et al, has clearly shown that this may be explained by the fact that the drug (in this case MEPA) does not cause abnormality or alteration of reproductive functions in female animals at the dose levels tested 26 .…”

Section: D E F G Hmentioning

confidence: 95%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

The present study was aimed to evaluate the effects of repeated administration of methanolic leaf extract of Pterospermum acerifolium Linn. Willd. (MEPA) on the reproductive system of male and female Wistar albino rats and its developmental effects on subsequent generation. MEPA was administered to Wistar albino rats by gavage for 28 days repeatedly at doses of 250, 500 and 1000 mg/kg body weight, in accordance to OECD guidelines 414 (developmental study) and 416 (reproductive study). Male fertility was estimated by sperm count. Biochemical evaluations included estimation of glycogen content, superoxide dismutase activity and ascorbic acid. Body weight and food intake behavior was also monitored regularly. MEPA treated male and female rats were allowed to mate. After mating females were observed for signs of parturition and allowed to give birth to the F1 generation. The pups were clinically observed. At the dose levels tested MEPA does not significantly (p<0.01) alter sperm count of male rats. Female reproductive system tolerates MEPA well. Normal gestational period was observed. Normal birth rates of F1 pups showed absence of developmental toxicity of MEPA. The no observed effect level (NOEL) for maternal and development toxicity was 1000 mg/kg/bw/d, the highest dose evaluated (p<0.01). MEPA does not cause male or female toxicity in Wistar albino rats upon 28 day repeated oral administration upon repeated MEPA administration upto 1000 mg/kg/bw/d. INTRODUCTION: An herb is a plant or plant part used for its scent, flavor, or therapeutic properties. Herbal medicines are one type of dietary supplement. They are sold as tablets, capsules, powders, teas, extracts, and fresh or dried plants.

show abstract

Reproductive safety evaluation of L-Ergothioneine

Cited by 30 publications

References 17 publications

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

The biology of ergothioneine, an antioxidant nutraceutical

Untitled

Contact Info

Product

Resources

About