Reproductive Endocrine Disorders in Men With Partial Seizures of Temporal Lobe Origin

Physical and Hormonal Profile of Male Sexual Development in Epilepsy

“…This was most evident in the group older than 16 years. Our results are in agreement with Fenwick et al (12), Herzog et al (13), Macpher et al (14), Ramsay and Salter (15), and Herzog (16); in all of these studies, mean values of total T serum levels were statistically significantly higher, whereas FT serum levels were lower than their matched controls.…”

Physical and Hormonal Profile of Male Sexual Development in Epilepsy

“…This was most evident in the group older than 16 years. Our results are in agreement with Fenwick et al (12), Herzog et al (13), Macpher et al (14), Ramsay and Salter (15), and Herzog (16); in all of these studies, mean values of total T serum levels were statistically significantly higher, whereas FT serum levels were lower than their matched controls.…”

The sexual and reproductive health in men with generalized epilepsy: a multidisciplinary evaluation

“…LH and FSH (n ¼ 10) were found to be increased in some of our patients, which indicates that affection is at the level of the gonades rather than the hypothalamic or pituitary levels. 26 Prolactin levels were found to be normal in most of our patients, which is consistent with many studies. 43 In contrast, several studies suggested that there is a clear relationship among hyperprolactinemia, low testosterone levels, and impotence, although the mechanisms responsible for ED with hyperprolactinemia are not solely secondary to decreased testosterone levels.…”

“…41 (2) Poor seizure control and untreated groups of epileptics exhibited more hormonal abnormalities than the controlled group on AED(s). Many evidences support our findings, including the following: free testosterone levels are usually low in reproductive endocrine disorders that are associated with TLE in men and therefore favor the occurrence of epileptiform activity, 26 testosterone has been found to raise the threshold of some induced seizures in experimental animals, 15,16 and previous studies demonstrated that patients with refractory epilepsy had improved sexual performance after temporal lobectomy. 37 AEDs has been incriminated for hormonal abnormalities among epileptic patients, which seem to be more among enzyme inducer-treated patients, for example, CBZ, utilized as monotherapy or combined with VPA.…”

Effect of Phenytoin on Semen

“…The effect of disease condition on testicular function in untreated epileptic males probably can be explained by the effect of seizures on hypothalamic pituitary gonadal functions. Altered hormonal levels have been reported (Herzog et al, 1986), although contrasting results have also been reported (Macphee et al, 1988). In our study, 44.4% of samples from untreated patients showed decreased testosterone level and one third (33.3%) showed increased LH and FSH levels, although the results were not consistent.…”

Physical and Hormonal Profile of Male Sexual Development in Epilepsy

“…This was most evident in the group older than 16 years. Our results are in agreement with Fenwick et al (12), Herzog et al (13), Macpher et al (14), Ramsay and Salter (15), and Herzog (16); in all of these studies, mean values of total T serum levels were statistically significantly higher, whereas FT serum levels were lower than their matched controls.…”

The sexual and reproductive health in men with generalized epilepsy: a multidisciplinary evaluation

“…LH and FSH (n ¼ 10) were found to be increased in some of our patients, which indicates that affection is at the level of the gonades rather than the hypothalamic or pituitary levels. 26 Prolactin levels were found to be normal in most of our patients, which is consistent with many studies. 43 In contrast, several studies suggested that there is a clear relationship among hyperprolactinemia, low testosterone levels, and impotence, although the mechanisms responsible for ED with hyperprolactinemia are not solely secondary to decreased testosterone levels.…”

“…41 (2) Poor seizure control and untreated groups of epileptics exhibited more hormonal abnormalities than the controlled group on AED(s). Many evidences support our findings, including the following: free testosterone levels are usually low in reproductive endocrine disorders that are associated with TLE in men and therefore favor the occurrence of epileptiform activity, 26 testosterone has been found to raise the threshold of some induced seizures in experimental animals, 15,16 and previous studies demonstrated that patients with refractory epilepsy had improved sexual performance after temporal lobectomy. 37 AEDs has been incriminated for hormonal abnormalities among epileptic patients, which seem to be more among enzyme inducer-treated patients, for example, CBZ, utilized as monotherapy or combined with VPA.…”

Effect of Phenytoin on Semen

“…The effect of disease condition on testicular function in untreated epileptic males probably can be explained by the effect of seizures on hypothalamic pituitary gonadal functions. Altered hormonal levels have been reported (Herzog et al, 1986), although contrasting results have also been reported (Macphee et al, 1988). In our study, 44.4% of samples from untreated patients showed decreased testosterone level and one third (33.3%) showed increased LH and FSH levels, although the results were not consistent.…”

Physical and Hormonal Profile of Male Sexual Development in Epilepsy

“…This was most evident in the group older than 16 years. Our results are in agreement with Fenwick et al (12), Herzog et al (13), Macpher et al (14), Ramsay and Salter (15), and Herzog (16); in all of these studies, mean values of total T serum levels were statistically significantly higher, whereas FT serum levels were lower than their matched controls.…”

The sexual and reproductive health in men with generalized epilepsy: a multidisciplinary evaluation

“…LH and FSH (n ¼ 10) were found to be increased in some of our patients, which indicates that affection is at the level of the gonades rather than the hypothalamic or pituitary levels. 26 Prolactin levels were found to be normal in most of our patients, which is consistent with many studies. 43 In contrast, several studies suggested that there is a clear relationship among hyperprolactinemia, low testosterone levels, and impotence, although the mechanisms responsible for ED with hyperprolactinemia are not solely secondary to decreased testosterone levels.…”

“…41 (2) Poor seizure control and untreated groups of epileptics exhibited more hormonal abnormalities than the controlled group on AED(s). Many evidences support our findings, including the following: free testosterone levels are usually low in reproductive endocrine disorders that are associated with TLE in men and therefore favor the occurrence of epileptiform activity, 26 testosterone has been found to raise the threshold of some induced seizures in experimental animals, 15,16 and previous studies demonstrated that patients with refractory epilepsy had improved sexual performance after temporal lobectomy. 37 AEDs has been incriminated for hormonal abnormalities among epileptic patients, which seem to be more among enzyme inducer-treated patients, for example, CBZ, utilized as monotherapy or combined with VPA.…”

Effect of Phenytoin on Semen

“…The effect of disease condition on testicular function in untreated epileptic males probably can be explained by the effect of seizures on hypothalamic pituitary gonadal functions. Altered hormonal levels have been reported (Herzog et al, 1986), although contrasting results have also been reported (Macphee et al, 1988). In our study, 44.4% of samples from untreated patients showed decreased testosterone level and one third (33.3%) showed increased LH and FSH levels, although the results were not consistent.…”