Reproductive characteristics and risk of kidney cancer: Iowa Women's Health Study

Molokwu, Jennifer; Prizment, Anna E.; Folsom, Aaron R.

doi:10.1016/j.maturitas.2007.07.003

Cited by 31 publications

(58 citation statements)

References 29 publications

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“…19 With regard to age at menopause or menopausal status, our results confirm previous null findings. [14][15][16][17][18]20 We do not confirm earlier suggestions of a relation between parity and RCC risk. Several epidemiological studies reported approximately doubled risks among women with 5 or more childbirths.…”

Section: Discussioncontrasting

confidence: 99%

“…Several epidemiological studies reported approximately doubled risks among women with 5 or more childbirths. 14,17,[20][21][22][23] However, in the present study, only 8% of cases and controls had 5 or more children. At this regard, it is also worth noting that a previous study observed an effect of parity mainly among overweight and hypertensive women, thus suggesting that parity might affect RCC risk by interacting with these 2 known RCC risk factors.…”

Section: Discussioncontrasting

confidence: 77%

“…15,16,18 Findings from the present study indicate a decreasing RCC risk for increasing age at first birth, in agreement with previous studies that found significant, 14,15,21 or nonsignificant inverse associations. 17,19,23 Recent longitudinal studies conducted in the United States among 37,440 women 20 and in Canada among 89,835 women 19 did not find a statistical significant association between OC use and RCC risk overall; however, when the analysis was stratified according to smoking status, OC use appeared to confer a 45% reduction in RCC risk among never smokers. 19 This reduction was in agreement with findings of 2 case-control.…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, our results indicate a slight increased RCC risk among HRT users, as already noted in Italy, 25 while other studies found significant increased risks among estrogenic-only HRT users. 17,18,20 As exogenous hormone use is not common in Italy (8 and 11% of our study group reported OC Ex-smokers were women who had quit smoking for at least 4 years.- 2 The sum does not add up to the total, because of some missing values (17 cases, 57 controls); current body mass index was used for women aged less than 30 years.- 3 In first-degree relatives.…”

Section: Discussionmentioning

confidence: 99%

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Reproductive, menstrual, and other hormone‐related factors and risk of renal cell cancer

Talamini

Maso

Negri

et al. 2008

Intl Journal of Cancer

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A role of hormone-related factors in renal cell cancer (RCC) etiology has been hypothesized, but the epidemiological evidence is inconsistent. The present study aimed at evaluating the effect of reproductive, menstrual and other gender-specific variables on RCC risk among women. This study is part of a larger hospitalbased, case-control study on RCC risk, conducted in northern, central and southern Italy. Cases were 273 women, below age 80, with histologically confirmed, incident RCC. Controls were 546 women hospitalized for acute, nonneoplastic conditions, frequency-matched to cases by age and center. Odds ratios (OR) and 95% confidence intervals (CI) were computed using multiple logistic regression models. RCC risk was inversely related to age at first birth (OR 5 0.7, 95% CI 0.5-1.0, for ≥25 years vs. <25 years). Hysterectomy was found to double RCC risk (OR 5 2.3, 95% CI 1.3-4.2). A negative association of borderline-statistical significance emerged for age at menarche, whereas, no associations were found between RCC risk and parity, menopausal status, age at menopause and use of hormone replacement therapy or oral contraceptives. Our findings give support to a role of hysterectomy in increasing RCC risk without corroborating, however, a major role of female hormone-related factors. ' 2008 Wiley-Liss, Inc.Key words: kidney cancer; reproductive and menstrual factors; hormones; hysterectomy; case-control study The kidney is among the 10 most common cancer sites in more developed countries. Worldwide, incidence rates are lower in women than in men, with 1:2 ratio. Such difference is recorded in Italy also, where the world-standardized incidence rates per 100,000 person-years are 11.5 and 4.6 among men and women, respectively. 1 Cigarette smoking, obesity and hypertension are the only established risk factors for renal cell cancer (RCC) (i.e., the most common type of kidney cancer) in both sexes. 2-5 Among potential risk factors, a role of hormone-related dynamics on RCC development has been hypothesized. To our knowledge, human studies have never examined endogenous estrogens with RCC risk. However, steroid hormone receptors have been found in normal and cancerous renal cell tissue, indicating possible hormonal regulations 6 ; this line of reasoning is strengthened by the observation that polymorphisms of the estrogen receptor gene were hypothesized to play a role in the pathogenesis of RCC. 7 Animal studies have shown that estrogens can promote or induce kidney cancer development. 8 In addition, obesity, which is consistently associated to RCC, provides a major source of estrogens in postmenopausal women. 9 To evaluate the role of menstrual and reproductive history, exogenous hormone use, and gynecologic surgery in RCC etiology in women, we conducted a multicentre, case-control study in Italy. Material and methodsThis study is part of a hospital-based, case-control study on RCC risk in both sexes, which has been described in details elsewhere. 10,11 The study was conducted between 1992 and 2004 in 4 Italian a...

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Reproductive, menstrual, and other hormone‐related factors and risk of renal cell cancer

Talamini

Maso

Negri

et al. 2008

Intl Journal of Cancer

View full text Add to dashboard Cite

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“…Typically, studies report a U or J-shaped relationship between parity and all-cause mortality (Doblhammer 2000;Hurt, Ronsmans & Thomas. 2006) or cardiovascular disease (Jaffe, Eisenbach & Manor 2011;Lawlor et al 2003;Parikh et al 2010), a positive relationship between parity and type-II diabetes (Mueller et al 2013;Nicholson et al 2006), and a variable (although more commonly negative) relationship for different cancers (Guan et al 2013;Kaae et al 2007;Kelsey, Gammon & John 1993;Molokwu, Prizment & Folsom 2007). As research linking parity to health has principally focused on direct physiological consequences of pregnancy and childbearing, most studies have excluded men.…”

Section: Fertility History and Healthmentioning

confidence: 99%

Family formation patterns and physical health in Australia: a life course approach

O’Flaherty¹

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Social science has long studied the relationships between processes of family formation and health, although empirical patterns in this domain of study are often variable, and their interpretation uncertain. Constrained by lack of suitable data, analytic techniques, and conceptual tools, work in this area has until recently been largely static, focussed on documenting and interpreting crosssectional associations between occupancy of family roles and health. However, as data and methodology matured and developed economies continued their transition away from the once dominant 'male breadwinner' model of the family, more sophisticated approaches that acknowledge the dynamic relationships between family formation and health have become both more feasible and more urgent.This thesis applies a life course approach to the study of family formation and health in the (2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014), and form the primary material for four empirical chapters. The first empirical chapter utilizes multichannel sequence analysis and growth models to investigate how holistic patterns of family formation (incorporating both partnership and fertility trajectories from ages 18-50) are associated with trajectories of physical health at ages 51 and older. For men, family life course trajectories characterized by early family formation, failure to marry, or early divorce without subsequent remarriage are found to be predictive of poorer health outcomes, while for women only those who experienced high fertility paired with a disrupted marital history were found to be in poorer health than those who experienced a normatively 'standard' family life course.The second, third, and fourth empirical chapters focus on different aspects of the relationship between parental age at first birth and later life heath. The first of these contextualizes changes in first birth timing in historical context, presents a descriptive analysis of the characteristics of younger/older first time mothers and fathers, and uses multinomial logistic regression to assess the contribution of early-life family and socio-economic disadvantage, health, and cognitive and noncognitive skills to first birth timing. Consistent with prior research, background family disadvantage and age at school leaving was found to have strong effects on birth timing, in particular for women.ii There was also some evidence of health selection into early first birth, with the largest effects again found for women.The third empirical chapter considers the effect of first birth timing on long-term health outcomes (ages 41 and older). In addition to the primary issue of whether there is an effect of birth timing on health, the analysis pays particular attention to several research questions: first, which pre- as mechanisms, as changes at the time of the parenthood transition and in the years thereafter did not differ depending on age at first birth. Younger parents do experience potentially harmful changes in alcohol use and soc...

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Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition

et al. 2023

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BackgroundRenal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology.Materials & MethodsWe investigated associations of age at menarche and age at menopause, pregnancy‐related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.ResultsDuring 15 years of follow‐up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use.ConclusionOur results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.

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Reproductive characteristics and risk of kidney cancer: Iowa Women's Health Study

Cited by 31 publications

References 29 publications

Reproductive, menstrual, and other hormone‐related factors and risk of renal cell cancer

Reproductive, menstrual, and other hormone‐related factors and risk of renal cell cancer

Family formation patterns and physical health in Australia: a life course approach

Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition

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