Reproduction study of grape colour extract in rats

(Poly)phenol toxicity in vivo following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and anthocyanin‐rich extracts

“…While no issues with reproductive performance were noted, rats consuming the 15% (w/w) diet had lower body weights as did their offspring. However, this was attributed to the lack of isocaloricity in the diets and not to the grape color itself (Becci, Hess, Babish, et al, 1983). These studies did not report the phenolic composition of the grape color.…”

(Poly)phenol toxicity in vivo following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and anthocyanin‐rich extracts

“…While no issues with reproductive performance were noted, rats consuming the 15% (w/w) diet had lower body weights as did their offspring. However, this was attributed to the lack of isocaloricity in the diets and not to the grape color itself (Becci, Hess, Babish, et al, 1983). These studies did not report the phenolic composition of the grape color.…”

Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics

“…A 2-generation reproductive study on grape color extract was performed using Sprague-Dawley rats. 69 The Code of Federal Regulations (21CFR73.169) states that the color additive grape color extract is an aq solution of anthocyanin grape pigments made from Concord grapes ( Vitis labrusca ) or a dehydrated water soluble powder prepared from the aq solution. The aq solution is prepared by extracting the pigments from precipitated lees produced during the storage of Concord grape juice.…”

Anthocyanins - nature, occurrence and dietary burden

“…According to JECFA,83 there was no coloration of the urine when dogs were given 500 mg by gastric fistula but, according to Timberlake,64 pigment was found in the bile and urine within 20 min and the lymph within 50 min. A reproductive study in rats90 and a subchronic toxicity study in beagle dogs91 both reported impaired body weight gain but failed to find any other deleterious effects when a commercial grape colour extract was given at 15% of the diet.…”

(Poly)phenol toxicity in vivo following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and anthocyanin‐rich extracts

“…While no issues with reproductive performance were noted, rats consuming the 15% (w/w) diet had lower body weights as did their offspring. However, this was attributed to the lack of isocaloricity in the diets and not to the grape color itself (Becci, Hess, Babish, et al, 1983). These studies did not report the phenolic composition of the grape color.…”

Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics

“…A 2-generation reproductive study on grape color extract was performed using Sprague-Dawley rats. 69 The Code of Federal Regulations (21CFR73.169) states that the color additive grape color extract is an aq solution of anthocyanin grape pigments made from Concord grapes ( Vitis labrusca ) or a dehydrated water soluble powder prepared from the aq solution. The aq solution is prepared by extracting the pigments from precipitated lees produced during the storage of Concord grape juice.…”

Anthocyanins - nature, occurrence and dietary burden

“…According to JECFA,83 there was no coloration of the urine when dogs were given 500 mg by gastric fistula but, according to Timberlake,64 pigment was found in the bile and urine within 20 min and the lymph within 50 min. A reproductive study in rats90 and a subchronic toxicity study in beagle dogs91 both reported impaired body weight gain but failed to find any other deleterious effects when a commercial grape colour extract was given at 15% of the diet.…”

(Poly)phenol toxicity in vivo following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and anthocyanin‐rich extracts

“…While no issues with reproductive performance were noted, rats consuming the 15% (w/w) diet had lower body weights as did their offspring. However, this was attributed to the lack of isocaloricity in the diets and not to the grape color itself (Becci, Hess, Babish, et al, 1983). These studies did not report the phenolic composition of the grape color.…”

Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics

“…A 2-generation reproductive study on grape color extract was performed using Sprague-Dawley rats. 69 The Code of Federal Regulations (21CFR73.169) states that the color additive grape color extract is an aq solution of anthocyanin grape pigments made from Concord grapes ( Vitis labrusca ) or a dehydrated water soluble powder prepared from the aq solution. The aq solution is prepared by extracting the pigments from precipitated lees produced during the storage of Concord grape juice.…”

Anthocyanins - nature, occurrence and dietary burden

“…According to JECFA,83 there was no coloration of the urine when dogs were given 500 mg by gastric fistula but, according to Timberlake,64 pigment was found in the bile and urine within 20 min and the lymph within 50 min. A reproductive study in rats90 and a subchronic toxicity study in beagle dogs91 both reported impaired body weight gain but failed to find any other deleterious effects when a commercial grape colour extract was given at 15% of the diet.…”