Reproducible measurements to quantify cutaneous involvement in scleroderma

Aghassi, D.

doi:10.1001/archderm.131.10.1160

Cited by 21 publications

(18 citation statements)

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“…Skin hardness may be affected by skin thickness as well as skin density, elasticity, and edema. Prior studies in SSc have found a correlation between clinical skin scores and durometry readings (14, 15). Other studies have found that normal skin hardness as measured by a durometer is relatively constant between the ages of 15 and 65 years (15) and does not correlate with body weight (14).…”

Section: Introductionmentioning

confidence: 88%

Durometry for the assessment of skin disease in systemic sclerosis

Kissin

Schiller

Gelbard

et al. 2006

Arthritis & Rheumatism

122

100

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Objective. To examine the validity of a durometer to objectively measure skin hardness in systemic sclerosis (SSc), and to compare digital durometry with the modified Rodnan skin score (MRSS) and ultrasonography. Methods. Patients with SSc and healthy controls underwent durometry measurements in 3 assessments: a Latin square experiment to establish durometry's intra-and interobserver reliability compared with skin scoring (5 SSc, 1 control); a longitudinal cohort to assess sensitivity to change in skin hardness (13 SSc, 5 controls); and an ultrasound cohort to evaluate correlation between durometry, ultrasound-measured skin thickness, and clinical skin scoring (30 SSc, 12 controls).

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Section: Introductionmentioning

confidence: 88%

Durometry for the assessment of skin disease in systemic sclerosis

Kissin

Schiller

Gelbard

et al. 2006

Arthritis & Rheumatism

122

100

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“…Skin: skin-specific scoring systems, 14 durometer, 14–16 histopathology, 15 or imaging (ultrasound, MRI) 17,18 …”

Section: Summary Of Recommendationsmentioning

confidence: 99%

Measuring Therapeutic Response in Chronic Graft-versus-Host Disease. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2014 Response Criteria Working Group Report

Lee

Wolff

Kitko

et al. 2015

Biology of Blood and Marrow Transplantation

320

303

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In 2005, the NIH Chronic GVHD Consensus Response Criteria Working Group recommended several measures to document serial evaluations of chronic GVHD organ involvement. Provisional definitions of complete response, partial response, and progression were proposed for each organ and for overall outcome. Based on publications over the last nine years, the 2014 Working Group has updated its recommendations for measures and interpretation of organ and overall responses. Major changes include elimination of several clinical parameters from the determination of response, updates to or addition of new organ scales to assess response, and the recognition that progression excludes minimal, clinically insignificant worsening that does not usually warrant a change in therapy. The response definitions have been revised to reflect these changes and are expected to enhance reliability and practical utility of these measures in clinical trials. Clarification is provided about response assessment after the addition of topical or organ-targeted treatment. Ancillary measures are strongly encouraged in clinical trials. Areas suggested for additional research include criteria to identify irreversible organ damage and validation of the modified response criteria, including in the pediatric population.

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“…To assess sclerodermatous change quantitatively, there are reports describing the use of suction devices (32-35), an elastometer (36), a rotational device (37), a durometer (9, lo), laser Doppler methods for blood flow (10,37), high-frequency ultrasound measuring skin thickness (37,38) and devices measuring transcutaneous oxygen pressure (37). Although we could not compare our present new probe with these methods, we think that our present method can definitely provide information about a distinct aspect of this disease.…”

Section: Skinmentioning

confidence: 99%

Palpation of the skin with a robot finger: an attempt to measure skin stiffness with a probe loaded with a newly developed tactile vibration sensor and displacement sensor

Sasai

Zhen

Suetake

et al. 1999

Skin Research and Technology

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Backgroundaims:Various attempts have been made to measure mechanical properties of the skin quantitatively and noninvasively. However, no attempt has been made to measure a tactile sense of our finger that palpates the skin; when we palpate the skin to search for any change, we at first rub the skin surface softly with a finger tip to detect a surface change and then press the finger against the skin to perceive any alteration in consistency. The problem here is how to record such tactile sense quantitatively, because the palpating examination for smoothness or softness of the skin totally depends on a subjective perception. A new tactile sensor from robot technology is equipped with a fingertip-like sensing probe oscillating at a resonant frequency of 60 kHz; it is capable of clearly sensing small differences in hardness of solid substances from a change in the oscillating frequency and from a displacement sensor that detects depressability of the skin. We have used this new measuring system to evaluate the hardness and elasticity of skin. Methods: We constructed a probe with two independent sensors, i.e., a newly developed tactile vibration sensor and a displacement sensor. To determine its usefulness we first used an in vitro skin model and subsequently used normal and lesional skin, such as neutrophilic erythema, keloid, hypertrophic scar, and scleroderma. Results: Two parameters were obtained with our probe: one that reflected superficial firmness of the skin, which mainly correlated with the hydration state of the stratum corneum, and the other that reflected the firmness of deeper tissue. Conclusion: Our results showed that this probe is useful for evaluating the physical properties of skin lesions that accompany changes in skin firmness.

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Reproducible measurements to quantify cutaneous involvement in scleroderma

Cited by 21 publications

References 0 publications

Durometry for the assessment of skin disease in systemic sclerosis

Durometry for the assessment of skin disease in systemic sclerosis

Measuring Therapeutic Response in Chronic Graft-versus-Host Disease. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2014 Response Criteria Working Group Report

Palpation of the skin with a robot finger: an attempt to measure skin stiffness with a probe loaded with a newly developed tactile vibration sensor and displacement sensor

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