Reproducibility of Optical Coherence Tomography Measurements in Children

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

“…For these acquired scans, our success rate was comparable to adult studies that report a failure rate between 2.5% and 12%, 3,9,11,32 although one pediatric study reported no imaging failures. 8 Our study has a number of limitations. The number of volumes acquired during an imaging session varied depending on a number of circumstances.…”

“…Many of current generation SD-OCT device typically report an excellent ICC (i.e., greater than 90%) and coefficient of variation below 4.0% for the global average and quadrant circumpapillary RNFL. [7][8][9][10][11][12] It is important to note that ICC values are population specific, so their values are not comparable between studies. Despite our lack of eye tracking and registration software, the CV results from our study are comparable to SD-OCT studies that enrolled adult healthy controls and those with glaucoma.…”

“…[1][2][3][4][5][6][7] The intra-and intervisit reproducibility of SD-OCT circumpapillary RNFL measures has recently been enhanced by eye tracking and registration technology, typically yielding an intraclass correlation coefficient (ICC) greater than 90% and coefficient of variation below 4.0%. [7][8][9][10][11][12] Despite the addition of eye tracking technology, many infants, toddlers, and young children frequently cannot cooperate with traditional table-mounted SD-OCT imaging due to their young age and or comorbid medical conditions. The development of a handheld SD-OCT has enabled pediatric practitioners to acquire high resolution images of the circumpapillary RNFL and macula in neonates, infants and young children.…”

Variations of OCT measurements corrected for the magnification effect according to axial length and refractive error in children

“…The total macular volume corresponds to the sum of the volumes of the neural retina in the central 6 mm of the macula. 19 The technique of OCT, 2,20,21 as well as its reproducibility in children, 18 has already been described in several reports. For image acquisition, an internal¯xation target was used to ensure proper alignment of the eye.…”

“…In each series of scans, average RNFL thickness and RNFL thickness in each quadrant (superior, inferior, temporal and nasal) were analyzed. 4,18 The macular images were obtained using a macular cube 512 Â 128 protocol. This protocol produces 128 horizontal scans at high resolution (512 A-scans per B-scan).…”