Reproducibility of continuous arterial spin labeling perfusion MRI after 7 weeks

Hermes, Michael; Hagemann, Dirk; Britz, Patrick; Lieser, Stefan; Rock, Jürgen; Naumann, Ewald; Walter, Christof

doi:10.1007/s10334-007-0073-3

Cited by 60 publications

(89 citation statements)

References 57 publications

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“…Based on the coefficient of variation which was 7.9 % in the global GM ROI, we conclude that the reproducibility of our measurements lies well in the range reported for other pulsed (28)(29)(30) and continuous ASL (31)(32)(33)(34) methods. A recent multi center study at 3T including 28 sites (29) using a PASL method termed QUASAR (35,36) reported values for SD w in GM between 3.01 and 8.12 ml/100 g/min, which suggests that the reproducibility of our measurements is quite high.…”

Section: Discussionsupporting

confidence: 83%

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Preibisch¹,

Sorg²,

Förschler³

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. Materials and Methods:Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique.Results: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique.Conclusion: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.

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Section: Discussionsupporting

confidence: 83%

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Preibisch¹,

Sorg²,

Förschler³

et al. 2011

Magnetic Resonance Imaging

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“…CASL, continuous arterial spin labeling; p-CASL, pseudo-continuous arterial spin labeling; s.d., standard deviation; TI PASL, inversion time pulsed arterial spin labeling. on reproducibility of these techniques (Floyd et al, 2003;Gevers et al, 2009a;Hermes et al, 2007;Jahng et al, 2005;Parkes et al, 2004). Looking at mean CBF values and the amount of data dispersion, as indicated by the CVs, we noticed that CASL and single TI PASL data from one site were largely responsible for this discrepancy.…”

Section: Discussionmentioning

confidence: 84%

Intra- and Multicenter Reproducibility of Pulsed, Continuous and Pseudo-Continuous Arterial Spin Labeling Methods for Measuring Cerebral Perfusion

Gevers

Osch

Bokkers

et al. 2011

J Cereb Blood Flow Metab

131

126

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Intra-and multicenter reproducibility of currently used arterial spin labeling (ASL) methods were assessed at three imaging centers in the Netherlands, equipped with Philips 3TMR scanners. Six healthy participants were scanned twice at each site. The imaging protocol consisted of continuous ASL (CASL), pseudo-continuous ASL (p-CASL) with and without background suppression, pulsed ASL (PASL) with single and multiple inversion times (TIs), and selective ASL for segmentation. Reproducibility was expressed in terms of the coefficient of repeatability and the repeatability index. Voxelwise analysis of variance was performed, yielding brain maps that reflected regional variability. Intra-and multicenter reproducibility were comparable for all methods, except for single TI PASL, with better intracenter reproducibility (F-test of equality of two variances, P < 0.05). Pseudocontinuous ASL and multi TI PASL varied least between sites. Variability maps of all methods showed most variability near brain-feeding arteries within sessions and in gray matter between sessions. On the basis of the results of this study, one could consider the use of reference values in clinical routine, with whole-brain p-CASL perfusion varying < 20% over repeated measurements within the same individuals considered to be normal. Knowledge on regional variability allows for the use of perfusion-weighted images in the assessment of local cerebral pathology.

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“…Only one study acquired CBF data both with participants' eyes open and closed. However, the assessment of test-retest reliability of CBF-mean was calculated based on the average CBF-mean of two resting states (Hermes et al, 2007).…”

Section: Test-retest Reliability Of Eyes-open and Eyes-closed Statesmentioning

confidence: 99%

“…BOLD fMRI studies have shown brain activity differences between the EO and EC states in the visual cortex (Jao et al, 2013;Liu et al, 2013;Yang et al, 2007;Zou et al, 2009;Zou et al, 2015), motor and auditory cortices (Jao et al, 2013;Liu et al, 2013;Yuan et al, 2014;Zou et al, 2015), and the default mode network (Jao et al, 2013;Liu et al, 2013;Yan et al, 2009). Using the ASL technique, significant CBF increases in the primary and secondary visual areas (Brodmann area (BA) 17, 18) for EO compared with EC state (Hermes et al, 2007;Zou et al, 2015) have been reported. Thus inconsistencies in resting states across studies may confound comparisons and interpretations among varied studies and impede big-data sharing which is of growing interest.…”

Section: Introductionmentioning

confidence: 99%

Reliability comparison of spontaneous brain activities between BOLD and CBF contrasts in eyes-open and eyes-closed resting states

et al. 2015

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Blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL) are two predominant resting-state fMRI techniques in mapping spontaneous brain activities. At single voxel level, cerebral blood flow (CBF) measured by ASL and amplitude of low frequency fluctuations (ALFF) of BOLD have been recognized as useful indices to characterize brain function in health and disease. However, no study has directly compared the test-retest reliability between BOLD and CBF contrasts on the same group of subjects at single voxel level. Moreover, both eyes-open and eyes-closed conditions have been employed as resting states, but it is still not clear which state is more reliable. Here we collected BOLD and ASL data during eyes-open and eyes-closed states across three scanning visits on twenty-two healthy young subjects. CBF-mean, BOLD-and CBF-ALFF were computed to characterize corresponding brain activities at single voxel level. Seed-based functional connectivity (FC) with the posterior cingulate cortex (PCC) was further calculated for both BOLD and CBF data. Intra-class correlation was used as the index of long-term reliability between visits 1 and 2 (two months apart) and short-term reliability between visits 2 and 3 (on the same day). Both short-and long-term reliabilities for CBF-mean and BOLD-ALFF were high, but were lower for CBF-ALFF, BOLD-and CBF-FC in both eyes-open and eyes-closed states. Direct comparisons showed that brain regions with the highest reliability of CBF-mean were mainly in the gray matter. The reliability of CBF-ALFF and BOLD-FC was lower than that of BOLD-ALFF, and the reliability of CBF-FC was lower than those of both CBF-ALFF and BOLD-FC. Furthermore, we observed that reliabilities of the eyes-open state were higher than those of the eyes-closed state for both imaging contrasts, though the effect size was small. Voxel-wise comparisons demonstrated that the long-term reliability of BOLD-ALFF was significantly higher with eyes open in the visual system, and both the short-and long-term reliability of BOLD-FC was slightly higher with eyes open in the default mode network. Moreover, we showed that denoising decreased the reliability of both ALFF and FC of both BOLD and ASL contrasts. In conclusion, our results indicated that CBF-mean and BOLD-ALFF could both be used as reliable indices for characterizing resting-state brain activities at single voxel level and recommended the eyesopen state for resting-state studies, especially for those targeting the visual system and default mode network.

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Reproducibility of continuous arterial spin labeling perfusion MRI after 7 weeks

Abstract: This study demonstrates the suitability of CASL to consistently detect differences between groups, regions, and resting states even after seven weeks. This emphasizes its usefulness for longitudinal designs.

Cited by 60 publications

References 57 publications

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Age‐related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Intra- and Multicenter Reproducibility of Pulsed, Continuous and Pseudo-Continuous Arterial Spin Labeling Methods for Measuring Cerebral Perfusion

Reliability comparison of spontaneous brain activities between BOLD and CBF contrasts in eyes-open and eyes-closed resting states

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