Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrument

Yoshida, Akitoshi; Feke, Gilbert T.; Mori, Fumihiko; Nagaoka, Taiji; Fujio, N; Ogasawara, Hironobu; Konno, Suguru; McMeel, J. Wallace

doi:10.1016/s0002-9394(02)01949-9

Cited by 110 publications

(99 citation statements)

References 11 publications

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“…Regarding their respective properties, the true rate of blood flow in retinal vessels can be more accurately determined using the laser Doppler method (Yoshida et al. 2003). However, comparatively more time is needed to calculate the measurements; therefore, subject compliance varies widely.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Takagi

Hirami

Takahashi

et al. 2018

Acta Ophthalmologica

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PurposeTo investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti®) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA).MethodsThis was an age‐ and refraction‐matched case–control study. Consecutive patients with a best‐corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone (FAZ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner segment ellipsoid (ISe) and external limiting membrane (ELM), the area without abnormal fluorescence in fundus autofluorescence (normal FAF area ratio) and the area of I‐2e of the Goldmann perimeter were analysed using mixed‐effects regression analysis.ResultsFoveal avascular zones were significantly smaller in patients with RP than in controls in superficial (p = 0.004) but not in deep layers (p = 0.25). The flow area in superficial (p = 0.007) and deep layers (p = 0.004) was significantly smaller in patients with RP than in controls. In patients with RP, flow areas in the superficial layers, but not in the deep layers, were significantly associated with the lengths of ISe (p = 0.001) and ELM (p = 0.002) and the I‐2e area (p = 0.036), but not with the normal FAF area ratio (p = 0.399).ConclusionOptical coherence tomography angiography (OCTA)‐measured flow area in superficial layers gradually reduced with RP progression and may be a useful parameter of RP pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Takagi

Hirami

Takahashi

et al. 2018

Acta Ophthalmologica

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“…8 The instrument is equipped with an automatic eye tracking system that maintains centration of the laser beam measuring on the target blood vessel even during eye movements. The beam from a red 675-nm diode laser is used for blood velocity measurements.…”

Section: Methodsmentioning

confidence: 99%

Retinal haemodynamics in patients with age-related macular degeneration

Satô

Feke

Menke

et al. 2005

Eye

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Objective To investigate whether there is an association between the magnitude of retinal haemodynamic abnormalities in patients with age-related macular degeneration (AMD) and the degree of severity of the AMD. Methods A retinal laser Doppler system (Canon CLBF 100) was used to measure retinal arterial haemodynamic parameters in 25 eyes of 25 patients with AMD and nine eyes of nine age-matched control subjects. Severity of AMD was classified into Mild (n ¼ 11), Moderate (n ¼ 7), or Severe (n ¼ 7). The pulsatility ratio (PR), the pulsatility index (PI), and the resistivity index (RI) were determined. Results PR, PI, and RI in the patients with AMD were each significantly higher than in the control group, and increased monotonically with increasing severity of AMD. However, there were no differences in mean blood velocity, arterial diameter, or blood flow rate among the groups. This suggests that the increased blood flow pulsatility in the retinal arteries of the eyes with AMD is not due to increased distal vascular resistance, but instead is likely due to a loss of compliance in the arterial vasculature leading to the eye. Conclusion Our results suggest that an increasing vascular rigidity in the systemic arterial circulation is directly associated with an increasing severity of AMD.

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“…Then, the positive results in the rabbits prompted us to study the effects of phenylephrine on the ONH and retinal circulation in humans using noninvasive laser methods. [19][20][21][22] …”

Section: Introductionmentioning

confidence: 99%

Topical phenylephrine decreases blood velocity in the optic nerve head and increases resistive index in the retinal arteries

Takayama

Mayama

Mishima

et al. 2008

Eye

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Purpose To investigate the effects of topical phenylephrine on circulation in the optic nerve head (ONH), posterior choroids, or retina in rabbits and healthy humans. Methods Tissue blood velocity in the ONH and posterior choroid was measured using the laser speckle method as normalized blur (NB ONH and NB CH ) in 28 anaesthetized albino rabbits. NB and intraocular pressure (IOP) in both eyes were measured for 180 min after unilateral single instillation of 5% phenylephrine and contralateral physiological saline as a control. In 11 normal volunteers aged 26.0±2.7 years, NB ONH was measured for 180 min after unilateral three drops of 5% phenylephrine and contralateral physiological saline in a double-masked manner. In the other 17 normal volunteers aged 25.5 ± 2.4 years, blood velocity and blood flow in a major branch of the central retinal artery were measured using the laser Doppler blood flow metre and IOP and systemic circulatory parameters were monitored in similar fashion. Analysis of variance was applied for intergroup comparisons.Results NB ONH and NB CH decreased significantly only in the phenylephrinetreated eyes in rabbits by maximum of 9 and 20%, respectively (P ¼ 0.0046 and 0.0009), despite IOP decrease. In humans, NB ONH decreased significant by maximum of 13% (P ¼ 0.0047) and resistive index in the retinal arteries increased by 10% (P ¼ 0.0067) unilaterally; whereas IOP, diameter, blood velocity, or blood flow of the arteries was not significantly changed. Conclusion Topical phenylephrine could exert a significant unfavourable effect on circulation in the ONH, choroidal tissue, and retinal arteries in rabbits and normal young humans.

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Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrument

Cited by 110 publications

References 11 publications

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Retinal haemodynamics in patients with age-related macular degeneration

Topical phenylephrine decreases blood velocity in the optic nerve head and increases resistive index in the retinal arteries

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