Reprint of: The new approach to epilepsy classification: Cognition and behavior in adult epilepsy syndromes

Baxendale, Sallie; Thompson, Pamela J.

doi:10.1016/j.yebeh.2016.11.025

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Regarding cognitive function, in addition to being influenced by genetic and environmental factors, antiepileptic drugs, sleep disruption and ictal disorders will also be influenced (Baxendale et al, 2016). Perampanel (PER) is an adjuvant treatment option for epileptic seizures and was evaluated in a systematic review with 9 studies between 2016 and 2021 evaluating cognitive effects, without considering behavioral changes.…”

Section: Antiepileptic Drugs Cognition and Behaviormentioning

confidence: 99%

Neuropsychiatric and cognitive comorbidities in epilepsy

Aguiar,

Albuquerque Filho

et al. 2023

RSD

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The epileptic crisis is characterized by a momentary episode of signs and symptoms that are caused by abnormal excessive or synchronous neuronal activity in the brain. On the other hand, epileptic syndrome is defined, according to the International League Against Epilepsy (ILAE), by “a group of clinical and neuroimaging characteristics in electroencephalographic (EEG) findings, many times, supported by specific etiologic findings (structural, genetic, metabolic, immunological and infectious)”. Accordingly, epilepsy patients have multiple neuropsychiatric comorbidities, being depressive disorders the most common, a condition that affects the quality of life and is influenced by numerous external factors. The present study aims to conduct a literature review based on the analysis of articles published from 2010 to 2022 in the PubMed (Medline) and Science Direct databases on epilepsy, its cognitive compromising and its neuropsychiatric comorbidities, using the terminology indicated by the System of Descriptors in Health Sciences (DeCS) and a set of predetermined criteria to select the best articles on the subject. Therefore, approaching psychiatric comorbidities, such as depressive disorders and cognitive deficiencies, in epilepsy is essential in light of its high prevalence and the negative repercussions in the patient's life. Consequently, more in-depth studies are necessary to provide a better prognosis for epilepsy patients and to evaluate the side effects and the clinical repercussions of Anti-Epileptic Drugs (AEDs).

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Section: Antiepileptic Drugs Cognition and Behaviormentioning

confidence: 99%

Neuropsychiatric and cognitive comorbidities in epilepsy

Aguiar,

Albuquerque Filho

et al. 2023

RSD

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“…Cognitive difficulties may be more disabling than seizures, significantly affecting quality of life ( Baxendale and Thompson, 2016 ). ASMs are, often chosen not because of their perceived efficacy but because of their cognitive SE profile.…”

Section: Introductionmentioning

confidence: 99%

Effect of Anti-seizure Medications on Functional Anatomy of Language: A Perspective From Language Functional Magnetic Resonance Imaging

et al. 2022

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BackgroundIn epilepsy, cognitive difficulties are common, partly a consequence of anti-seizure medications (ASM), and cognitive side-effects are often considered to be more disabling than seizures and significantly affect quality of life. Functional MRI during verbal fluency tasks demonstrated impaired frontal activation patterns and failed default mode network deactivation in people taking ASM with unfavourable cognitive profiles. The cognitive effect of ASMs given at different dosages in monotherapy, or in different combinations, remains to be determined.MethodsHere, we compared the effects of different drug loads on verbal fluency functional MRI (fMRI) in people (i) taking dual therapy of ASMs either considered to be associated with moderate (levetiracetam, lamotrigine, lacosamide, carbamazepine/oxcarbazepine, eslicarbazepine, valproic acid; n = 119, 56 females) or severe (topiramate, zonisamide) side-effects; n = 119, 56 females), (ii) taking moderate ASMs in either mono-, dual- or triple-therapy (60 subjects in each group), or (iii) taking different dosages of ASMs with moderate side-effect profiles (n = 180). “Drug load” was defined as a composite value of numbers and dosages of medications, normalised to account for the highest and lowest dose of each specific prescribed medication.ResultsIn people taking “moderate” ASMs (n = 119), we observed higher verbal-fluency related to left inferior frontal gyrus and right inferior parietal fMRI activations than in people taking “severe” ASMs (n = 119). Irrespective of the specific ASM, people on monotherapy (n = 60), showed greater frontal activations than people taking two (n = 60), or three ASMs (n = 60). People on two ASMs showed less default mode (precuneus) deactivation than those on monotherapy. In people treated with “moderate” ASMs (n = 180), increased drug load correlated with reduced activation of language-related regions and the right piriform cortex.ConclusionOur study delineates the effects of polytherapy and high doses of ASMs when given in monotherapy on the functional anatomy of language. Irrespective of the cognitive profile of individual ASMs, each additional ASM results in additional alterations of cognitive activation patterns. Selection of ASMs with moderate cognitive side effects, and low doses of ASMs when given in polytherapy, could reduce the cognitive effect.

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Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account

Rayner

Tailby

2017

Curr Neurol Neurosci Rep

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Some implications of a network conceptualisation of epilepsy include a need for more widespread cognitive phenotyping in epilepsy; recognition that memory disorders in epilepsy can be multi-determined, including by non-structural factors; deeper consideration given to the neurodevelopmental context in which memory problems emerge; the utility of new methods to characterise memory impairments in epilepsy; and a call for greater recognition of the close interrelationships between memory comorbidities and psychiatric symptoms in epilepsy. Memory disorder significantly worsens the quality of life of people with epilepsy, underscoring the importance to patient wellbeing of giving due consideration to the up-to-date neuropsychological practises outlined in this review.

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Reprint of: The new approach to epilepsy classification: Cognition and behavior in adult epilepsy syndromes

Cited by 3 publications

References 27 publications

Neuropsychiatric and cognitive comorbidities in epilepsy

Neuropsychiatric and cognitive comorbidities in epilepsy

Effect of Anti-seizure Medications on Functional Anatomy of Language: A Perspective From Language Functional Magnetic Resonance Imaging

Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account

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