Moringa oleifera
is also known as “Miracle tree”, due to its multiple uses and adaptability. Because of nutritive and pharmacological values, it is widely cultivated across the world.
M. oleifera
leaves are rich source of minerals, vitamins and many health beneficial secondary metabolites, and possess significant anti-diabetic potential. Consequently,
Insilco
study could be noteworthy to expand effective anti-diabetic drugs from this plant. Present study was designed to find out the best bioactive compounds of
M. oleifera
as a potential therapeutic agent against diabetes mellitus through
In-silico
method. For this, structures of phytochemicals were extracted from PubChem and docked to mutated protein from PBD. Afterwards, datasets were prepared for ligand based pharmacophore and their pharmacophoric features were generated from LigandScout. Finally five phytochemicals viz. anthraquinone, 2-phenylchromenylium (Anthocyanins), hemlock tannin, sitogluside (glycoside) and A-phenolic steroid were selected, which exhibited effective binding within the active binding pocket of the targeted protein. Ligand based pharmacophore model showed the key features i.e. HBD, HBA, aromatic ring, hydrophobic, positively ionizable surface essential for receptor binding. Our findings suggest that screened phytochemicals present in
M. oleifera
can be used as potential therapeutic drug candidates to treat diabetes mellitus.
Moringa oleifera
is also known as “Miracle tree”, due to its multiple uses and adaptability. Because of nutritive and pharmacological values, it is widely cultivated across the world.
M. oleifera
leaves are rich source of minerals, vitamins and many health beneficial secondary metabolites, and possess significant anti-diabetic potential. Consequently,
Insilco
study could be noteworthy to expand effective anti-diabetic drugs from this plant. Present study was designed to find out the best bioactive compounds of
M. oleifera
as a potential therapeutic agent against diabetes mellitus through
In-silico
method. For this, structures of phytochemicals were extracted from PubChem and docked to mutated protein from PBD. Afterwards, datasets were prepared for ligand based pharmacophore and their pharmacophoric features were generated from LigandScout. Finally five phytochemicals viz. anthraquinone, 2-phenylchromenylium (Anthocyanins), hemlock tannin, sitogluside (glycoside) and A-phenolic steroid were selected, which exhibited effective binding within the active binding pocket of the targeted protein. Ligand based pharmacophore model showed the key features i.e. HBD, HBA, aromatic ring, hydrophobic, positively ionizable surface essential for receptor binding. Our findings suggest that screened phytochemicals present in
M. oleifera
can be used as potential therapeutic drug candidates to treat diabetes mellitus.
“…However, LD50 alone does not indicate the extent of the toxicity and cannot be equivalent to acute toxicity. Rather, it only indicates the toxicity of a compound 107 . Chronic toxicity will be the ability of a chemical to cause damage following repeated exposure to relatively low doses for a long time.…”
Science has been trying to deal with complex diseases, like cancer, for a long time. Indeed, the side effects of the conventional treatment methods are tremendous, in some cases irreversible. This kind of problems demands a solution. Therefore, novel drug delivery systems are devised to mitigate the negative impacts of conventional ones. Polymeric nanocarrier systems are of great importance in this newly opened field. Polymers having been vastly investigated are common in some properties, such as their being biocompatibility and biodegradability. Generally speaking, a set of properties is required to achieve optimum delivery of drugs to target organs with minimum side effects. To do so, some measures should be taken. First of all, the strategy for release should be determined, categorized into two main branches, active and passive. Next, the drug release method should be engineered. Generally, there are two main categories for drug release, exogenous and endogenous. In this review, some of the chief subcategories of any aforementioned items are discussed. In the end, we catch up on already engineered nanocarriers' administration to the human body, possible toxic effects, if any, and the routes for affecting as a toxin.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
