Report on Clinical Use of BRL 1241 in Children with Staphylococcal and Streptococcal Infections

Stewart, Gordon T.; Nixon, H. H.; Coles, H. M. T.; Kesson, C. W.; Lawson, David H.; Thomas, Robert G.; Mishra, Jaishree; Mitchell, Marisa E.V.; Semmens, J. M.; Wade, T. H. H.

doi:10.1136/bmj.2.5200.703

Cited by 31 publications

(3 citation statements)

References 8 publications

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“…Staphylococcal pneumonia is another testing ground for an antibiotic. Among 20 reported cases in adults," 12,22,25,29,31 including 1 of our own, 16 patients recovered. This recovery rate of 80 per cent is only slightly better than that of 75 per cent observed in similar pneumonias treated by us with a variety of antibiotics in the past 10 years."…”

Section: O_s-ciipmentioning

confidence: 65%

“…The best test of an antistaphylococcal drug is in staphylococcal bacteremia. Twenty-five patients with staphylococcal bacteremia treated with methicillin have been reported in the Iiterature.v 12,15,22,25,29,31,35 12 of whom recovered. Five of the failures were in highly artificial situations in which Spitz-Holter valves,' which had been inserted to obtain a ventriculocaval shunt, became infected.…”

Section: O_s-ciipmentioning

confidence: 99%

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The newer penicillins

Dowling¹

1961

Clin Pharma and Therapeutics

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Section: O_s-ciipmentioning

confidence: 65%

Section: O_s-ciipmentioning

confidence: 99%

The newer penicillins

Dowling¹

1961

Clin Pharma and Therapeutics

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“…However, other investigators have reported that nasal staphylococci are eradicated less frequently and less rapidly from patients receiving methicillin for staphylococcal infections at other sites (7)(8)(9).…”

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confidence: 99%

Suppression of Nasal, Skin, and Aerial Staphylococci by Nasal Application of Methicillin*

Varga¹,

White²

1961

J. Clin. Invest.

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Untreated heavy nasal carriers of staphylococci have been reported to have staphylococci on their skin more frequently and to disseminate staphylococci in the air in larger numbers than either noncarriers or carriers of smaller numbers of these bacteria (1). If the nose is the main source of skin and aerial staphylococci, suppression of nasal staphylococci should be followed by a reduction in both aerial dissemination and skin carriage.Of the presently available systemically administered antibiotics, only methicillin (dimethoxyphenyl penicillin) has been reported to eradicate staphylococci from nasal carriers without overt staphylococcal infections at other sites in hospitals where a large proportion of these organisms is multiple-drug-resistant (2-6). However, other investigators have reported that nasal staphylococci are eradicated less frequently and less rapidly from patients receiving methicillin for staphylococcal infections at other sites (7)(8)(9).In the present study nasal treatment with methicillin not only suppressed nasal staphylococci but also decreased aerial dissemination of these organisms and markedly reduced skin carriage of staphylococci. Both before and after treatment, the frequency of positive skin cultures and aerial dissemination of staphylococci was proportional to the number of nasal staphylococci isolated at the time cultures were obtained. METHODSQuantitative nasal cultures (10) were obtained 4 or 5 times per week, January

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Antistaphylococcal Activity of Sodium Methicillin

White¹,

Varga²

1961

Arch Intern Med

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Report on Clinical Use of BRL 1241 in Children with Staphylococcal and Streptococcal Infections

Cited by 31 publications

References 8 publications

The newer penicillins

The newer penicillins

Suppression of Nasal, Skin, and Aerial Staphylococci by Nasal Application of Methicillin*

Antistaphylococcal Activity of Sodium Methicillin

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