Abstract:We thank Palma et al for bringing to our attention the 3-arm randomized controlled trial (RCT) from China by Lv et al. 1 We agree with many of the limitations of any Surveillance, Epidemiology, and End Results (SEER) study that they point out. Specifically, confounding because of unmeasured covariates is always a potential source of error in observational studies. However, in our study, we conducted a thorough sensitivity analysis to assess the effects of unmeasured variables, such as clinical tumor staging. 2… Show more
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