Reply to the letter from von Stackelberg et al

Abstract

always be available and then marker combinations from primary disease have to be employed. In this context, it would be helpful to communicate data on stability of marker combinations at initial diagnosis and at relapse. Furthermore, the number of marker combinations used for MRD quantification should be mentioned. 3 Irrespective of methodological differences in several study groups, it seems obvious that the measurement of MRD represents a new and globally working biological principle that can be applied to predict the prognosis of childhood ALL with a given therapy more reliably than any other known method.A von