>2 consecutive years. Plasma and dried blood spot (DBS) were collected at time of consent. Drugs were measured in plasma and DBS at the University of Colorado Antiviral Pharmacology Laboratory (previously described).(2,3) Tenofovir, emtricitabine (FTC), and raltegravir (RAL) were quantified in plasma, and TFV-DP and the intracellular form of emtricitabine (FTC-TP) were quantified in DBSs, both using a validated liquid chromatography tandem mass spectrometry method. (2,3) To date, we have enrolled 2 patients (…
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