Reperfusion Injury

Zimmerman, Barbara; Granger, D. Neil

doi:10.1016/s0039-6109(16)45628-8

Cited by 264 publications

(163 citation statements)

References 27 publications

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“…The potent antioxidant effect of T M Z has been demonstrated in myocardial, renal, and hepatic IR injury [7,17,20,22]. A significant increase in MDA levels has been observed in various organs including the liver, kidney, and intestine during IR injury [7,16,19,23,24]. In this study, the elevated levels of MDA in the control group supported the notion that lipid peroxidation processes occur during IR injury.…”

Section: Discussionsupporting

confidence: 81%

“…It is directly proportional to the numbers of neutrophils seen in histological sections of intestine tissue, and is therefore regarded as a reliable index of neutrophil infiltration [4,5,8,24,251. It has been reported that MPO activity in intestinal tissue increases threefold after 60 min of intestinal ischemia, and eight to ninefold after 60min of reperfusion [12].…”

Section: Discussionmentioning

confidence: 99%

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Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats

Tetik

Özden

Çallı

et al. 1999

Transplant International

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Trimetazidine (TMZ), a potent antioxidant agent, has been used to protect the myocardium, liver and kidney from ischemia reperfusion (IR) injury. We investigated the effect of TMZ, a cellular antiischemic agent and a free radical scavenger, on 60 rnin of warm intestinal IR injury in rats. SpragueDawley rats were divided into three groups: a sham-operated group (no IR injury, n = S), an ischemic control group (control, n = 8), and a TMZtreated group (3 mg/kg, y1 = 8). Malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity, and mucosal damage were investigated after 120 min of reperfusion. MDA levels and MPO activity were more elevated and histopathological damage more severe in the control group than in the sham group ( P < 0.05). MDA levels and MPO activity were lower and there was less histopathological damage in the T M Z group than in the control group ( P < 0.0s). Accumulation of lipid peroxidation products and neutrophils in mucosal tissues were significantly inhibited by TMZ treatment. We conclude that pretreatment of rats with TMZ before intestinal ischemia attenuates but does not prevent, histological damage.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats

Tetik

Özden

Çallı

et al. 1999

Transplant International

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“…During reperfusion, while the oxygen and metabolic needs of the tissue are met [4] , introducing oxygen into the cell creates free oxygen radicals, and more severe damage occurs compared to the damage caused by the ischemia [5] . Free oxygen radicals deform the structure of the cell membrane and disrupt the function of the transport system in the cell membrane due to lipid peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Ratlarda Böbrek İşemi/Reperfüzyon Hasarına Karşı Tiyopentalin Koruyucu Etkisi

Çoşkuner¹,

Türkay²,

Yıldız³

et al. 2016

Kafkas Univ Vet Fak Derg

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The aim of this study was to determine optimal protective thiopental dose in renal ischemia/reperfusion (I/R) damage. This study was carried out on 42 rats. After abdominal midline incision, left renal artery was occluded. After 60 min of ischemia and reperfusion, a left nephrectomy was performed. Surgical intervention was made for the six rat groups (excluding sham group). In control group, 60 minutes of ischemia and reperfusion were applied to left kidneys. Thiopental (3, 10, 30, 60, 80 mg/ kg) was applied intra-peritoneally to the rats except sham and control groups 15 minutes before reperfusion. After reperfusion, IL-1α, IL-6, TNF-α levels; SOD activity; MDA and NO levels were measured. There was no decrease in IL-6 or TNF-α levels in groups at all doses. IL-1α levels only decreased in the group receiving 3 mg/kg thiopental. Only the group receiving 80 mg/kg observed decrease in MDA levels. The rats receiving 30 mg/kg showed significant increase in SOD levels. The rats receiving 3 mg/ kg detected significant increase in glutathione peroxidase (GPx) levels. The groups receiving 10, 30, and 60 mg/kg thiopental showed decrease in nitric oxide (NO) levels. According to study results, different doses of thiopental affected each biochemical indicator in renal I/R damage. Keywords: Renal Ischemia/Reperfusion, Thiopental, Rat Ratlarda Böbrek İşemi/Reperfüzyon Hasarına Karşı Tiyopentalin Koruyucu Etkisi ÖzetÇalışmada ratlarda farklı dozlarda uygulanan tiyopentalin renal I/R hasarına karşı koruyucu optimal dozunun saptanması amaçlandı. Bu çalışma 42 ratta yapıldı. Abdominal orta hat insizyonu sonrası sol renal arter okluzyonu yapıldı. Altmış dakika işemi ve reperfüzyondan sonra sol nefrektomi yapıldı. Altışar rattan oluşan gruplarda (sham grup dışında) cerrahi prosedür uygulandı. Kontrol grubunda sol böbreklere 60 dk işemi ve reperfüzyon uygulandı. Sham ve kontrol grubu dışındaki ratlara reperfüzyondan 15 dk önce tiyopental (3, 10, 30, 60, 80 mg/kg) intra-peritoneal olarak uygulandı. Reperfüzyon sonunda IL-1α, IL-6, TNF-α seviyeleri; SOD aktivitesi; MDA ve NO düzeyleri ölçüldü. Gruplarda IL-6 ve TNF-α seviyelerinde azalma olmadı. Yalnızca 3 mg/kg tiyopental uygulanan grupta IL-1α seviyesi azaldı. MDA düzeylerinde düşme yalnızca 80 mg/kg tiyopental uygulanan grupta görüldü. 30 mg/ kg tiyopental uygulanan ratlarda SOD düzeylerinde anlamlı yükseklik saptandı. 3 mg/kg tiyopental uygulanan ratlarda glutatyon peroksidaz (GPx) düzeylerinde anlamlı yükseklik saptandı. Nitrik oksit seviyesindeki düşme 10, 30 ve 60 mg/kg tiyopental uygulanan gruplarda görüldü. Çalışma sonuçlarına göre, renal işemi reperfüzyon hasarında her bir biyokimyasal belirteci tiyopentalin farklı dozları etkiledi.

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“…1 Ischemia is the occurrence of oxygen deprivation in the tissue due to a reduction or a complete cessation in the blood stream reaching the tissue. 2 The longterm oxygen deprivation in the organs and tissues leads to necrosis (death of cells). For this reason, the first response/ intervention to be made on the tissue with ischemia is to enable the tissue to be reperfused.…”

Section: Introductionmentioning

confidence: 99%

The effect of nimesulide on oxidative damage inflicted by ischemia–reperfusion on the rat renal tissue

et al. 2014

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The objective of our study is to research biochemically and histopathologically the effect of nimesulide on oxidative damage inflicted by ischemia-reperfusion (I/R) on the rat renal tissue. Twenty-four albino Wistar type of male rats were used for the experiment. The animals were divided into groups as: renal ischemia-reperfusion control (RIR), nimesulide + renal ischemiareperfusion of 50 mg/kg (NRIR-50), nimesulide + renal ischemia-reperfusion of 100 mg/kg (NRIR-100), and sham groups (SG). In NRIR-50 and NRIR-100 groups were given nimesulide, and RIR and SG groups were given distilled water, an hour after anesthesia. Groups, except for the SG group, 1-h-ischemia and then 6-h-reperfusion were performed. In the renal tissue of the RIR group in which the malondialdehyde (MDA), myeloperoxidase (MPO), and 8-hydroxyguanine (8-OHGua) levels were measured, the COX-1 and COX-2 activities were recorded. Nimesulide at 100 mg/kg doses reduced the oxidant parameters more significantly than 50 mg/kg doses; on the other hand, it raised the antioxidant parameters. It has been shown that 100 mg/kg doses of nimesulide prevented the renal I/R damage more significantly than a dose of 50 mg/kg, which shows that nimesulide, in clinics, could be used in the prevention of I/R damage.

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Reperfusion Injury

Cited by 264 publications

References 27 publications

Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats

Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats

Ratlarda Böbrek İşemi/Reperfüzyon Hasarına Karşı Tiyopentalin Koruyucu Etkisi

The effect of nimesulide on oxidative damage inflicted by ischemia–reperfusion on the rat renal tissue

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