1992
DOI: 10.1161/01.str.23.9.1337
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Abstract: Background and Purpose: Neutrophils are critically involved with ischemia and reperfusion injury in many tissues but have not been studied under conditions of reperfusion after focal cerebral ischemia. The present studies were conducted to confirm our previous observations quantifying neutrophils in rat permanent focal stroke using a myeloperoxidase activity assay and to extend them to transient ischemia with reperfusion. In addition, leukotriene B 4 receptor binding in ischemic tissue was evaluated as a poten… Show more

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Cited by 171 publications
(93 citation statements)
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References 78 publications
(54 reference statements)
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“…The role of neutrophils in the progression of ischemic damage has been extensively studied in transient focal cerebral ischemia by the use of the MPO activity assay since Barone et al (1991) first used it to indirectly quantify neutrophil accumulation in the brain. In fact, the use of MPO, whether in the biochemical activity assay or as an immunomarker, has become a predominant method used to measure neutrophil infiltration (Barone et al, 1992;Batteur-Parmentier et al, 2000;Beray-Berthat et al, 2003a;Chopp et al, 1996;Feuerstein et al, 1998;Jiang et al, 1995;Kitagawa et al, 1998;Matsuo et al, 1994;Zhang et al, 1995). Myeloperoxidase has traditionally been described as a useful marker for neutrophil infiltration within damaged tissue, because it is primarily localized in neutrophils (Barone et al, 1991), but it has also been shown to be expressed in monocytes and macrophages (Kochanek and Hallenbeck, 1992) although in much smaller amounts (Bos et al, 1978;Zhang and Chopp, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…The role of neutrophils in the progression of ischemic damage has been extensively studied in transient focal cerebral ischemia by the use of the MPO activity assay since Barone et al (1991) first used it to indirectly quantify neutrophil accumulation in the brain. In fact, the use of MPO, whether in the biochemical activity assay or as an immunomarker, has become a predominant method used to measure neutrophil infiltration (Barone et al, 1992;Batteur-Parmentier et al, 2000;Beray-Berthat et al, 2003a;Chopp et al, 1996;Feuerstein et al, 1998;Jiang et al, 1995;Kitagawa et al, 1998;Matsuo et al, 1994;Zhang et al, 1995). Myeloperoxidase has traditionally been described as a useful marker for neutrophil infiltration within damaged tissue, because it is primarily localized in neutrophils (Barone et al, 1991), but it has also been shown to be expressed in monocytes and macrophages (Kochanek and Hallenbeck, 1992) although in much smaller amounts (Bos et al, 1978;Zhang and Chopp, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…Contralateral forelimb deficits were measured using a neurological grade (Bederson et aI., 1986) and contralateral hindlimb deficits were measured using the hindlimb placement test (Barone et al, 1991a(Barone et al, ,b, 1992. Animals were euthanized using sodium pentobarbital at 4 or 24 h postsurgery and the forebrain was dissected into four segments as described in detail previously (Barone et al, 1991a(Barone et al, , 1992 and outlined schematically in Fig. 1.…”
Section: Methodsmentioning
confidence: 99%
“…These cytokines, including tumor necrosis factor alpha (TNF)-, interlukin (IL)-1, and IL-8, drive inflammatory processes and accelerate additional inflammatory processes by inducing inflammatory molecules, such as intercellular adhesion molecule (ICAM), vascular cell adhesion molecule-1 (VCAM-1), and selectins. All these inflammatory modulators will induce more inflammatory leukocytes to infiltrate into ischemic region and lead to further loss of neuronal cells (3)(4)(5)(6). Anti-inflammatory cytokines, such as IL-10 and transforming growth factor (TGF)-1, suppress the production of pro-inflammatory cytokine in protection of damaged brain tissues after ischemic stroke (7).…”
Section: Introductionmentioning
confidence: 99%